MHY1485 | mTOR Activator | AmBeed-信号通路专用抑制剂

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MHY1485 {[allProObj[0].p_purity_real_show]}

货号：A165303 同义名： 4,6-二吗啉-N-(4-硝基苯基)-1,3,5-三嗪-2-胺

MHY1485是一种有效的、细胞可渗透的mTOR激活剂，靶向mTOR的ATP域，并通过抑制自噬体与溶酶体的融合来抑制自噬。

MHY1485 化学结构
CAS号：326914-06-1

MHY1485 3D分子结构
CAS号：326914-06-1

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MHY1485 纯度/质量文件产品仅供科研

货号：A165303 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell Host Microbe, 2024. Ambeed. [ A163338 ]; • Cancer Res., 2024. Ambeed. [ A295334 ]; • J. Pharm. Investig., 2024. Ambeed. [ A221527 , A691302 , A272538 , A187261 ]; • J. Fungi, 2024, 10(11): 751. Ambeed. [ A796919 ]; • JBC, 2024, 107935. Ambeed. [ A194396 ]; 更多 >

mTOR 亚型比较
自噬亚型比较

产品名称	mTOR ↓ ↑	mTORC1 ↓ ↑	mTORC2 ↓ ↑	其他靶点	纯度
AZD-8055	++++ mTOR (truncated), IC50: 0.13 nM mTOR (full length), IC50: 0.8 nM				99%+
Gedatolisib	++++ mTOR, IC50: 1.6 nM				98%
GSK1059615	++ mTOR, IC50: 12 nM				98%
Vistusertib	+++ mTOR, IC50: 2.8 nM				99%+
Torin 1	+++ mTOR, IC50: 4.32 nM	+++ mTORC1, IC50: 2 nM	++ mTORC2, IC50: 10 nM	DNA-PK	99%+
Dactolisib	+++ mTOR (p70S6K), IC50: 6 nM				98+%
PI-103	+ mTOR, IC50: 30 nM				99%+
WAY-600	++ mTOR, IC50: 9 nM				99%
Voxtalisib	+ mTOR, IC50: 157 nM				99%+
PF-04691502	++ mTOR, Ki: 16 nM				98+%
Onatasertib	++ mTOR, IC50: 16 nM			DNA-PK	99%+
Chrysophanol	✔			EGFR	98%
Samotolisib	✔			DNA-PK	99%+
Torkinib	+++ mTOR, IC50: 8 nM			PDGFR,DNA-PK	99%+
Everolimus					99%+
WYE-354	+++ mTOR, IC50: 5 nM				98%
Tacrolimus	✔				98%
PP121	++ mTOR, IC50: 13 nM			VEGFR,PDGFR	99%+
Torin 2	++++ mTOR, IC50: 0.25 nM			DNA-PK	99%+
Rapamycin	++++ mTOR, IC50: ~0.1 nM				98%
GDC-0349	+++ mTOR, Ki: 3.8 nM				98%
XL388	++ mTOR, IC50: 9.9 nM	+++ mTORC1, IC50: 8 nM	+ mTORC2, IC50: 166 nM		99%+
WYE-687	+++ mTOR, IC50: 7 nM				98+%
Apitolisib	+ mTOR, Ki app: 17 nM				98%+
WYE-132	++++ mTOR, IC50: 0.19 nM				99%+
Sapanisertib	++++ mTOR, Ki: 1.4 nM				99%+
BGT226 maleate	✔				99%+
ETP-46464	++++ mTOR, IC50: 0.6 nM			DNA-PK	98%
PI3K-IN-1	+ mTOR, IC50: 157 nM				98+%
Zotarolimus	+++ FKBP-12, IC50: 2.8 nM				99+%
OSI-027	+++ mTOR, IC50: 4 nM	+ mTORC1, IC50: 22 nM	+ mTORC2, IC50: 65 nM		99%+
Ridaforolimus	++++ mTOR, IC50: 0.2 nM				99%+
Temsirolimus	+ mTOR, IC50: 1.76 μM				99%
CZ415	++ mTOR, pIC50: 8.07				99%+
SF2523	+ mTOR, IC50: 280 nM			DNA-PK	99%+
KU-0063794		++ mTORC1, IC50: ~10 nM	++ mTORC2, IC50: ~10 nM		99%+
Omipalisib		++++ mTORC1, Ki: 0.18 nM	++++ mTORC2, Ki: 0.3 nM		99%+
Palomid 529		✔			99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	Autophagy ↓ ↑	其他靶点	纯度
SBI-0206965	+++ ULK2, IC50: 711 nM ULK1, IC50: 108 nM		97%
Hydroxychloroquine sulfate	✔		99%
Valproic acid sodium	✔	HDAC	97%
PFK-015	++ PFKFB3, IC50: 207 nM		99%+
MRT68921 hydrochloride	++++ ULK2, IC50: 1.1 nM ULK1, IC50: 2.9 nM		99%+
ROC-325	✔		99%+
Autophinib	+++ Autophagy, IC50: 40 nM		97%
Lys05	✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

MHY1485 生物活性

描述

Autophagy is a complicated process that consists of autophagosome biogenesis, maturation, and fusion with lysosomes, which can be induced by mtor inhibitor such as rapamycin. MHY1485 can activate mtor and suppress the basal autophagic flux in cells under starvation. It was shown that the LC3II/LC3I ratio and LC3II-positive vacuoles can be increased by simply treatment of MHY1485 2uM. However, compared with the group only with 10 nM bafilomycin A1 or 100uM chloroquine, treatment of MHY1485 2uM can decrease the LC3II protein level in Ac2F cells under starvation. These indicated that MHY1485 can suppress autophagic flux induced by starvation. Also the increase of both p-mTOR-Ser2448/mTOR ratio and the p4E-BP1-Thr37/46/4E-BP1 can be detected after treating cells with 2uM MHY1485, which indicated the activation of mTOR by MHY1485 ^[1]

作用机制

MHY1485 showed a high docking score with the ATP domain of mTOR.

MHY1485 动物研究

Dose	Mice: 3 μg/kg^[2] (i.p.), 10 mg/kg^[3] (i.p.)
Administration	i.p.

MHY1485 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.58mL

0.52mL

0.26mL

12.91mL

2.58mL

1.29mL

25.81mL

5.16mL

2.58mL

MHY1485 技术信息

CAS号	326914-06-1
分子式	C₁₇H₂₁N₇O₄
分子量	387.393

别名	4,6-二吗啉-N-(4-硝基苯基)-1,3,5-三嗪-2-胺
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

DMSO: 6 mg/mL(15.49 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

MHY1485 {[allProObj[0].p_purity_real_show]}

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MHY1485 {[allProObj[0].p_purity_real_show]}

MHY1485 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

MHY1485 质控信息

MHY1485 生物活性

MHY1485 动物研究

MHY1485 实验方案

MHY1485 技术信息

最近浏览的产品

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MHY1485 纯度/质量文件产品仅供科研