JP1302 2HCl is a potent, selective, high affinity α2C-adrenoceptor antagonist with a Kb of 16 nM and a Ki of 28 nM for human α2C-receptors. JP1302 2HCl has antidepressant and antipsychotic-like effects. JP1302 2HCl can be used in neuropsychiatric and renal dysfunction studies [1][2][3].
JP1302 2HCl 动物研究
Animal study
JP1302 2HCl administered in the dose range of 1-10 μmol/kg reduces the immobility time in FST to a level similar to that of the 10-30 μmol/kg antidepressant Desipramine[1]JP1302 2HCl administered sequentially once at a dose of 5 μmol/kg was able to completely reverse PPI damage induced by the psychotomimetic NMDA receptor antagonist phencyclidine in Sprague-Dawley rats, and similar results were found in Wistar rats[1].JP1302 2HCl at a dose of 3 mg/kg administered once intravenously 5 minutes before ischaemia induction significantly renal dysfunction in male Sprague Dawley rats [3].
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