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JP1302 2HCl

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Chemical Structure| 1259314-65-2 同义名 : JP1302 dihydrochloride
CAS号 : 1259314-65-2
货号 : A316550
分子式 : C24H26Cl2N4
纯度 : 99%+
分子量 : 441.396
MDL号 : MFCD10565599
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(9.06 mM)，配合低频超声，并调节pH至5，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 12 mg/mL(27.19 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 JP1302 2HCl is a potent, selective, high affinity α2C-adrenoceptor antagonist with a Kb of 16 nM and a Ki of 28 nM for human α2C-receptors. JP1302 2HCl has antidepressant and antipsychotic-like effects. JP1302 2HCl can be used in neuropsychiatric and renal dysfunction studies [1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.27mL

0.45mL

0.23mL

11.33mL

2.27mL

1.13mL

22.66mL

4.53mL

2.27mL
参考文献

[1]Tricklebank MD, et al. JP-1302: a new tool to shed light on the roles of alpha2C-adrenoceptors in brain. Br J Pharmacol. 2007 Feb;150(4):381-2.

[2]Sallinen J, et al. Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302. Br J Pharmacol. 2007 Feb;150(4):391-402.

[3]Shimokawa T, et al. Post-treatment with JP-1302 protects against renal ischemia/reperfusion-induced acute kidney injury in rats. J Pharmacol Sci. 2019 Mar;139(3):137-142.