Se-Methylselenocysteine | 3-(甲基硒基)-L-丙氨酸 | Methylselenocysteine | Chemopreventive Agent

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L-硒甲基硒代半胱氨酸 /H-3-(Me-Se)-Ala-OH {[allProObj[0].p_purity_real_show]}

货号：A361358 同义名： 3-(甲基硒基)-L-丙氨酸 / Methylselenocysteine;Se-Methylseleno-L-cysteine

H-3-(Me-Se)-Ala-OH是甲基硒的前体，表现出强大的化学预防和抗氧化活性，能够通过诱导细胞凋亡抑制癌细胞增殖，具有良好的口服生物活性。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

H-3-(Me-Se)-Ala-OH 化学结构
CAS号：26046-90-2

H-3-(Me-Se)-Ala-OH 3D分子结构
CAS号：26046-90-2

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H-3-(Me-Se)-Ala-OH 纯度/质量文件产品仅供科研

货号：A361358 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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转化生长因子-β 亚型比较

产品名称	ALK1 ↓ ↑	ALK2 ↓ ↑	ALK3 ↓ ↑	ALK4 ↓ ↑	ALK6 ↓ ↑	Smad3 ↓ ↑	TGF-β ↓ ↑	TGFβRI/ALK5 ↓ ↑	TGFβRII ↓ ↑	纯度
LDN193189	++++ ALK1, IC50: 0.8 nM	++++ ALK2, IC50: 0.8 nM	+++ ALK3, IC50: 5.3 nM		+++ ALK6, IC50: 16.7 nM					99%+
LDN-212854	++++ ALK1, IC50: 2.4 nM	++++ ALK2, IC50: 1.3 nM	+ ALK3, IC50: 85.8 nM	+ ALK4, IC50: 2133 nM				+ ALK5, IC50: 9276 nM		99%+
ML347	++ ALK1, IC50: 46 nM	++ ALK2, IC50: 32 nM								98%
K02288	++++ ALK1, IC50: 1.8 nM	++++ ALK2, IC50: 1.1 nM	++ ALK3, IC50: 34.4 nM		+++ ALK6, IC50: 6.4 nM					99%+
LDN-193189 dihydrochloride	++++ ALK1, IC50: 0.8 nM	++++ ALK2, IC50: 0.8 nM	+++ ALK3, IC50: 5.3 nM		+++ ALK6, IC50: 16.7 nM					99%
LDN-214117		++ ALK2, IC50: 24 nM								98%
DMH-1		+ ALK2, IC50: 107.9 nM								99%+
SB-505124				+ ALK4, IC50: 129 nM				++ ALK5, IC50: 47 nM		99%+
Vactosertib				+++ ALK4, IC50: 13 nM				+++ ALK5, IC50: 11 nM		99%+
Alantolactone						✔				98%
SIS3						✔				97%
Pirfenidone							✔			98%
Hesperetin							✔			97%
RepSox								++++ TGFβR1(ALK5), IC50: 4 nM		98%
GW788388								+++ ALK5, IC50: 18 nM		98%
LY364947								++ TGFβRI, IC50: 59 nM	+ TGFβRII, IC50: 0.4 μM	98%
SD-208								++ TGF-βRI (ALK5), IC50: 48 nM		98%
SB-525334								+++ TGFβR1(ALK5), IC50: 14.3 nM		99%+
LY2109761								++ TβRI, Ki: 38 nM	+ TβRII, Ki: 300 nM	99%+
Galunisertib								++ TβRI, IC50: 56 nM		98%
SB 431542								+ ALK5, IC50: 94 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

H-3-(Me-Se)-Ala-OH 生物活性

描述

Se-Methylselenocysteine has strong cancer chemopreventive activity and antioxidant activity. Se-Methylselenocysteine is orally active and induces apoptosis^[1]^[2].Acting in the concentration range of 100-400 μM for 3 days, Se-Methylselenocysteine induced caspase-3-mediated apoptosis in SKOV-33 cells, leading to a significant increase in sub-G1 phase accumulation^[1]^[2].

H-3-(Me-Se)-Ala-OH 动物研究

Animal study

Se-Methylselenocysteine, administered orally once daily for 14 days at a dose of 0.2 mg/mouse, potentiated the antitumour activity of CDDP and cyclophosphamide in nude mice bearing human FaDu and A253 head and neck xenografts^[2].

H-3-(Me-Se)-Ala-OH 参考文献

[1]Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92.

[2]Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43.

H-3-(Me-Se)-Ala-OH 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

5.49mL

1.10mL

0.55mL

27.46mL

5.49mL

2.75mL

54.92mL

10.98mL

5.49mL

H-3-(Me-Se)-Ala-OH 技术信息

CAS号	26046-90-2
分子式	C₄H₉NO₂Se
分子量	182.08

别名	3-(甲基硒基)-L-丙氨酸 ;Methylselenocysteine;Se-Methylseleno-L-cysteine;SeMCys;Se-MSC;MSeC
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

H₂O: 85 mg/mL(466.83 mM)，配合低频超声助溶

动物实验配方

L-硒甲基硒代半胱氨酸 /H-3-(Me-Se)-Ala-OH {[allProObj[0].p_purity_real_show]}

H-3-(Me-Se)-Ala-OH 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

H-3-(Me-Se)-Ala-OH 质控信息

H-3-(Me-Se)-Ala-OH 生物活性

H-3-(Me-Se)-Ala-OH 动物研究

H-3-(Me-Se)-Ala-OH 参考文献

H-3-(Me-Se)-Ala-OH 实验方案

H-3-(Me-Se)-Ala-OH 技术信息

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L-硒甲基硒代半胱氨酸 /H-3-(Me-Se)-Ala-OH {[allProObj[0].p_purity_real_show]}

H-3-(Me-Se)-Ala-OH 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

H-3-(Me-Se)-Ala-OH 质控信息

H-3-(Me-Se)-Ala-OH 生物活性

H-3-(Me-Se)-Ala-OH 动物研究

H-3-(Me-Se)-Ala-OH 参考文献

H-3-(Me-Se)-Ala-OH 实验方案

H-3-(Me-Se)-Ala-OH 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

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临床研究

确认信息

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