PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay.

PF-06648671是一种新型的、能够透过血脑屏障并具有口服活性的 γ-分泌酶 (γ-Secretase) 调节剂 (GSM)。它减少 Aβ42 和 Aβ40，同时增加 Aβ37 和 Aβ38，用于阿尔茨海默病的研究。

Fosciclopirox是 γ-分泌酶（γ-secretase）抑制剂，具有抗尿路上皮癌的潜力，通过靶向 γ-分泌酶来抑制癌细胞生长。

Eslicarbazepine (BIA 2-194)是一种口服抗惊厥剂，可用于局部癫痫的辅助研究。

Isorubrofusarin-6-O-β-gentiobioside (Isorubrofusarin gentiobioside)是一种天然化合物，属于蒽醌类化合物，是从决明子种子中分离出的萘并吡喃酮糖苷，具有抗氧化、抗炎和抗癌活性。

E 2012 is a potent γ-secretase modulator.

LY2886721是一种有效的、选择性的、口服活性的β-位淀粉样前体蛋白裂解酶1（BACE1）抑制剂，对重组人BACE1的IC50为20.3 nM。LY2886721对BACE1具有选择性，但对组织蛋白酶D、胃蛋白酶和肾素缺乏选择性（IC50为10.2 nM）。LY2886721可穿过血脑屏障，可用于阿尔茨海默病研究。

Verubecestat is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.

AZD3839 is an inhibitor of BACE1 with IC50 of 23.6 uM.

Scoulerine, a natural product isolated and purified from the herbs of Corydalis dubia., shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively.

LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.

Nodakenetin is a natural product isolated and purified from the herbs of Peucedanum decursivum Maxim. with clinical efficacy.

LY 2886721 hydrochloride is the first oral inhibitor of human β-secretase (BACE-1) with the potential to treat Alzheimer's Disease.

L-685458 is an inhibitor of amyloid β-protein precursor gamma-secretase activity with Ki of 17 nM.

Se-Methylselenocysteine hydrochloride是甲基硒的前体，具有显著的抗癌化学预防和抗氧化活性。该化合物能够诱导细胞凋亡，具有口服生物活性，广泛用于癌症预防和抗氧化剂研究。

Dibenzazepine is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively.

H-3-(Me-Se)-Ala-OH是甲基硒的前体，表现出强大的化学预防和抗氧化活性，能够通过诱导细胞凋亡抑制癌细胞增殖，具有良好的口服生物活性。

PF-3084014 is a reversible inhibitor of γ-secretase with IC50 of 6.2 nM.

CHF5074 is a γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.

Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC50 of 13 nM against phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC50s of 0.30 μM, 0.17 μM, 17.89 μg/mL, 10.98 μM, 8.37 μM and 8.21 μM, respectively.