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H-3-(Me-Se)-Ala-OH

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Chemical Structure| 26046-90-2 同义名 : 3-(甲基硒基)-L-丙氨酸 ;Methylselenocysteine;Se-Methylseleno-L-cysteine;SeMCys;Se-MSC;MSeC
CAS号 : 26046-90-2
货号 : A361358
分子式 : C4H9NO2Se
纯度 : 99%+
分子量 : 182.08
MDL号 : MFCD00800565
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 85 mg/mL(466.83 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Se-Methylselenocysteine has strong cancer chemopreventive activity and antioxidant activity. Se-Methylselenocysteine is orally active and induces apoptosis[1][2].Acting in the concentration range of 100-400 μM for 3 days, Se-Methylselenocysteine induced caspase-3-mediated apoptosis in SKOV-33 cells, leading to a significant increase in sub-G1 phase accumulation[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.49mL

1.10mL

0.55mL

27.46mL

5.49mL

2.75mL

54.92mL

10.98mL

5.49mL
参考文献

[1]Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92.

[2]Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43.