There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Cyamemazine, a neuroleptic containing the phenothiazine chromophore, is often utilized for its anxiolytic properties. It is a potent antagonist at 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM), and 5-HT2C (Ki = 75 nM) receptors, demonstrating antipsychotic activity[1][2].
体内研究
Cyamemazine acts as an antagonist at the 5-HT3, 5-HT2C, and 5-HT2A receptors, affecting 5-HT3-dependent contractions in isolated guinea pig ileum, 5-HT2C-dependent phospholipase C activation in rat brain membranes, and 5-HT2A-dependent contractions in isolated rat aorta rings and guinea pig trachea. Its antagonism of 5-HT3 and 5-HT2C receptors partially explains its therapeutic action in anxiety disorders. Acute, low doses of Cyamemazine reduce extracellular dopamine and its metabolites in the rat striatum[1].
体外研究
Cyamemazine shows high affinity for dopamine receptors, aligning with its antipsychotic effects. It also displays antagonist activity at muscarinic receptors, with affinities for M1 (Ki = 13 nM), M2 (Ki = 42 nM), M3 (Ki = 321 nM), M4 (Ki = 12 nM), and M5 (Ki = 35 nM) receptors[1].
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