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Cyamemazine

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Chemical Structure| 3546-03-0 同义名 : -
CAS号 : 3546-03-0
货号 : A411163
分子式 : C19H21N3S
纯度 : 98%
分子量 : 323.455
MDL号 : MFCD00868180
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(324.62 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Cyamemazine, a neuroleptic containing the phenothiazine chromophore, is often utilized for its anxiolytic properties. It is a potent antagonist at 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM), and 5-HT2C (Ki = 75 nM) receptors, demonstrating antipsychotic activity[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.09mL

0.62mL

0.31mL

15.46mL

3.09mL

1.55mL

30.92mL

6.18mL

3.09mL
参考文献

[1]Bourin M, et al. Preclinical and clinical pharmacology of cyamemazine: anxiolytic effects and prevention of alcohol and benzodiazepine withdrawal syndrome. CNS Drug Rev. 2004 Fall;10(3):219-29.

[2]Vendrell-Criado V, et al. Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environment. J Photochem Photobiol B. 2020 Jan;202:111686.