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CLK1-IN-3 {[allProObj[0].p_purity_real_show]}

货号:A2420433 Ambeed 开学季,买赠积分,赢豪礼

CLK1-IN-3是一种选择性 Clk1 激酶抑制剂,IC50 为 5 nM,对 Clk1 的抑制作用比 Dyrk1A 高 300 倍,能有效诱导自噬 (autophagy),广泛用于急性肝损伤研究。

CLK1-IN-3 化学结构 CAS号:2922550-28-3
CLK1-IN-3 化学结构
CAS号:2922550-28-3
CLK1-IN-3 3D分子结构
CAS号:2922550-28-3
CLK1-IN-3 化学结构 CAS号:2922550-28-3
CLK1-IN-3 3D分子结构 CAS号:2922550-28-3
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CLK1-IN-3 纯度/质量文件 产品仅供科研

货号:A2420433 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

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产品名称 Autophagy 其他靶点 纯度
SBI-0206965 +++

ULK2, IC50: 711 nM

ULK1, IC50: 108 nM

{[allProObj[0].p_purity_real_show]}
Hydroxychloroquine sulfate {[allProObj[0].p_purity_real_show]}
Valproic acid sodium HDAC {[allProObj[0].p_purity_real_show]}
PFK-015 ++

PFKFB3, IC50: 207 nM

{[allProObj[0].p_purity_real_show]}
MRT68921 hydrochloride ++++

ULK2, IC50: 1.1 nM

ULK1, IC50: 2.9 nM

{[allProObj[0].p_purity_real_show]}
ROC-325 {[allProObj[0].p_purity_real_show]}
Autophinib +++

Autophagy, IC50: 40 nM

{[allProObj[0].p_purity_real_show]}
Lys05 {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
产品名称 DYRK DYRK1 DYRK2 其他靶点 纯度
ID-8 {[allProObj[0].p_purity_real_show]}
AZ191 ++++

DYRK1B, IC50: 17 nM

DYRK1A, IC50: 88 nM

{[allProObj[0].p_purity_real_show]}
Harmine +++

DYRK1B, IC50: 166 nM

DYRK1A, IC50: 33 nM

++

DYRK2, IC50: 1.9 μM

{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
产品名称 Cdc CDK1 CDK19 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CLK 其他靶点 纯度
XL413 hydrochloride ++++

Cdc7, IC50: 3.4 nM

{[allProObj[0].p_purity_real_show]}
SU9516 +++

CDK1, IC50: 40 nM

+++

CDK2, IC50: 22 nM

++

CDK4, IC50: 200 nM

{[allProObj[0].p_purity_real_show]}
RO-3306 +++

CDK1, Ki: 20 nM

ERK,SGK {[allProObj[0].p_purity_real_show]}
R547 ++++

CDK1/CyclinB, Ki: 2 nM

++++

CDK2/CyclinE, Ki: 3 nM

++++

CDK4/CyclinD1, Ki: 1 nM

{[allProObj[0].p_purity_real_show]}
BMS-265246 ++++

CDK1/CyclinB, IC50: 6 nM

++++

CDK2/CyclinE, IC50: 9 nM

+

CDK4/CyclinD, IC50: 230 nM

{[allProObj[0].p_purity_real_show]}
NU6027 +

CDK1, Ki: 2.5 μM

+

CDK2, Ki: 1.3 μM

DNA-PK {[allProObj[0].p_purity_real_show]}
Purvalanol A ++++

Cdc2/CyclinB, IC50: 4 nM

+++

CDK2/CyclinE, IC50: 35 nM

CDK2/CyclinA, IC50: 70 nM

+

CDK4/CyclinD1, IC50: 850 nM

{[allProObj[0].p_purity_real_show]}
SCH900776 ++

CDK2, IC50: 0.16 μM

{[allProObj[0].p_purity_real_show]}
AUZ 454 ++++

CDK2(A144C), Kd: 9.7 nM

CDK2(C118L), Kd: 18.6 nM

{[allProObj[0].p_purity_real_show]}
A-674563 HCl ++

CDK2, Ki: 46 nM

PKA {[allProObj[0].p_purity_real_show]}
JNJ-7706621 ++++

CDK1/CyclinB, IC50: 9 nM

++++

CDK2/CyclinE, IC50: 3 nM

CDK2/CyclinA, IC50: 4 nM

++

CDK3/CyclinE, IC50: 58 nM

+

CDK4/CyclinD1, IC50: 253 nM

++

CDK6/CyclinD1, IC50: 175 nM

{[allProObj[0].p_purity_real_show]}
AT7519 ++

CDK1/CyclinB, IC50: 210 nM

++

CDK2/CyclinA, IC50: 47 nM

+

CDK3/CyclinE, IC50: 360 nM

++

CDK4/CyclinD1, IC50: 100 nM

+++

CDK5/p35, IC50: 13 nM

++

CDK6/CyclinD3, IC50: 170 nM

++++

CDK9/CyclinT, IC50: <10 nM

{[allProObj[0].p_purity_real_show]}
PHA-793887 ++

CDK1/CyclinB, IC50: 60 nM

++++

CDK2/CyclinE, IC50: 8 nM

CDK2/CyclinA, IC50: 8 nM

++

CDK4/CyclinD1, IC50: 62 nM

++++

CDK5/p25, IC50: 5 nM

++++

CDK7/CyclinH, IC50: 10 nM

++

CDK9/CyclinT1, IC50: 138 nM

{[allProObj[0].p_purity_real_show]}
Milciclib +

CDK1/CyclinB, IC50: 398 nM

++

CDK2/CyclinE, IC50: 363 nM

CDK2/CyclinA, IC50: 45 nM

++

CDK4/CyclinD1, IC50: 160 nM

+

CDK5/p35, IC50: 265 nM

++

CDK7/CyclinH, IC50: 150 nM

{[allProObj[0].p_purity_real_show]}
Kenpaullone +

CDK1/CyclinB, IC50: 0.4μM

+

CDK2/CyclinE, IC50: 7.5μM

CDK2/CyclinA, IC50: 0.68μM

+

CDK5/p35, IC50: 0.85μM

{[allProObj[0].p_purity_real_show]}
SNS-032 +++

CDK2/CyclinE, IC50: 48 nM

CDK2/CyclinA, IC50: 38 nM

+

CDK5/p35, IC50: 340 nM

++

CDK7/CyclinH, IC50: 62 nM

++++

CDK9/CyclinT, IC50: 4 nM

{[allProObj[0].p_purity_real_show]}
Dinaciclib ++++

CDK1, IC50: 3 nM

++++

CDK2, IC50: 1 nM

++++

CDK5, IC50: 1 nM

++++

CDK9, IC50: 4 nM

{[allProObj[0].p_purity_real_show]}
PHA-767491 hydrochloride ++++

Cdc7, IC50: 10 nM

+

CDK1, IC50: 250 nM

+

CDK2, IC50: 240 nM

+

CDK5, IC50: 460 nM

+++

CDK9, IC50: 34 nM

MK2 {[allProObj[0].p_purity_real_show]}
(R)-Roscovitine +

Cdc2/CyclinB, IC50: 0.65 μM

+

CDK2/CyclinE, IC50: 0.7 μM

CDK2/CyclinA, IC50: 0.7 μM

++

CDK5/p35, IC50: 0.16 μM

{[allProObj[0].p_purity_real_show]}
Narazaciclib ++++

CDK4/CyclinD1, IC50: 3.87 nM

++++

CDK6/CyclinD1, IC50: 9.82 nM

RET {[allProObj[0].p_purity_real_show]}
Palbociclib ++++

CDK4/CyclinD1, IC50: 11 nM

CDK4/CyclinD3, IC50: 9 nM

+++

CDK6/CyclinD2, IC50: 15 nM

{[allProObj[0].p_purity_real_show]}
Abemaciclib ++++

CDK4, IC50: 2 nM

++++

CDK6, IC50: 10 nM

{[allProObj[0].p_purity_real_show]}
Ribociclib ++++

CDK4, IC50: 10 nM

+++

CDK6, IC50: 39 nM

{[allProObj[0].p_purity_real_show]}
Palbociclib isethionate ++++

CDK4/CyclinD1, IC50: 11 nM

CDK4/CyclinD3, IC50: 9 nM

+++

CDK6/CyclinD2, IC50: 15 nM

{[allProObj[0].p_purity_real_show]}
BS-181 HCl +++

CDK7, IC50: 21 nM

{[allProObj[0].p_purity_real_show]}
(E/Z)-THZ1 dihydrochloride ++++

CDK7, IC50: 3.2 nM

{[allProObj[0].p_purity_real_show]}
LDC4297 ++++

CDK7, IC50: 0.13 nM

{[allProObj[0].p_purity_real_show]}
Senexin A +

CDK19, Kd: 0.31 μM

+

CDK8, Kd: 0.83 μM

{[allProObj[0].p_purity_real_show]}
MSC2530818 ++++

CDK8, IC50: 2.6 nM

{[allProObj[0].p_purity_real_show]}
Wogonin {[allProObj[0].p_purity_real_show]}
Riviciclib HCl ++

CDK1/CyclinB, IC50: 79 nM

+

CDK2/CyclinE, IC50: 2.54 μM

CDK2/CyclinA, IC50: 224 nM

++

CDK4/CyclinD1, IC50: 63 nM

+

CDK6/CyclinD3, IC50: 396 nM

+

CDK7/CyclinH, IC50: 2.87 μM

+++

CDK9/CyclinT1, IC50: 20 nM

{[allProObj[0].p_purity_real_show]}
LDC000067 +

CDK2, IC50: 2.441 μM

++

CDK9, IC50: 44 nM

{[allProObj[0].p_purity_real_show]}
Flavopiridol +++

CDK1, IC50: 40 nM

+++

CDK2, IC50: 40 nM

+++

CDK4, IC50: 40 nM

+++

CDK6, IC50: 40 nM

+

CDK7, IC50: 300 nM

+++

CDK9, IC50: 20 nM

{[allProObj[0].p_purity_real_show]}
LY2857785 +

CDK7, IC50: 0.246 μM

+++

CDK8, IC50: 0.016 μM

+++

CDK9, IC50: 0.011 μM

{[allProObj[0].p_purity_real_show]}
AZD-5438 +++

CDK1, IC50: 16 nM

++++

CDK2, IC50: 6 nM

+++

CDK9, IC50: 20 nM

{[allProObj[0].p_purity_real_show]}
ML167 ++

Dyrk1B , IC50: 1648 nM

CLK4, IC50: 136 nM

{[allProObj[0].p_purity_real_show]}
(E/Z)-TG003 +++

mCLK1, IC50: 200 nM

mCLK4, IC50: 15 nM

{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

CLK1-IN-3 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.32mL

0.46mL

0.23mL

11.62mL

2.32mL

1.16mL

23.23mL

4.65mL

2.32mL

CLK1-IN-3 技术信息

CAS号2922550-28-3
分子式C24H23FN6O
分子量 430.477
别名
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(243.92 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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