ID-8 is an inhibitor of DYRK inhibitor that can sustain embryonic stem cell self-renewal and survival without differentiation.
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描述 | The dual-specificity tyrosine-phosphorylation-regulated (DYRK) kinases belong to a family collectively referred to as CMGC kinases that includes cyclin dependent kinases, mitogen associated protein kinases, glycogen synthase kinases, and cyclin dependent-like kinases. ID-8, a DYRK inhibitor, shows high specificity for DYRK1A and DYRK1B with IC50s of 78 and 54 nM, respectively[3]. ID-8 increased hESC (human embryonic stem cells) survival (∼1.1% at 0.5 μM). The combination of Wnt3a and ID-8 further increased survival (∼1.7%) and completely prevented Wnt-induced differentiation morphologically without disrupting proliferation. Wnt-induced differentiation marker gene expression was dramatically reduced by ID-8 at a dose that maintained the undifferentiated state[4]. Treatment with ID-8 (10 µM) promoted significant increases in cell number after 24 hours of damage in at least two different damage models[5]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.35mL 0.67mL 0.34mL |
16.76mL 3.35mL 1.68mL |
33.52mL 6.70mL 3.35mL |
CAS号 | 147591-46-6 |
分子式 | C16H14N2O4 |
分子量 | 298.293 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 45 mg/mL(150.86 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |