货号:A350584
同义名:
哈尔碱
/ Telepathine
Harmine是一种天然的双特异性酪氨酸磷酸化调节激酶(DYRK)抑制剂,具有抗癌和抗炎活性。它对5-HT2A血清素受体具有高亲和力,Ki值为397 nM。
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产品名称 | MAO ↓ ↑ | MAO-A ↓ ↑ | MAO-B ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sennoside A |
++
MAO, IC50: 17 μM |
99%+ | |||||||||||||||||
Glycyrrhizic acid |
++++
MAO, IC50: 0.16 μM |
80% HPLC | |||||||||||||||||
Rasagiline |
++++
MAO-A, IC50: 412 nM |
++++
MAO-B, IC50: 4.43 nM |
99+% | ||||||||||||||||
Isatin |
++
MAO, IC50: 15 μM |
+
MAO-A, IC50: 58 μM |
++
MAO-B, IC50: 14 μM |
99%+ | |||||||||||||||
Paeonol |
+
MAO-A, IC50: 54.6 μM |
+
MAO-B, IC50: 42.5 μM |
99%+ | ||||||||||||||||
Tranylcypromine hydrochloride |
+++
MAO-A, IC50: 11.5 μM |
+++
MAO-B, IC50: 7 μM |
99%+ | ||||||||||||||||
Moclobemide |
+++
MAO-A (5-HT), IC50: 6.1 μM |
99%+ | |||||||||||||||||
Pargyline HCl |
++
MAO-A, Ki: 13 μM |
+++
MAO-B, Ki: 0.5 μM |
99%+ | ||||||||||||||||
Safinamide |
++++
MAO-B, IC50: 98 nM |
99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Harmine is a beta-carboline alkaloid found in medicinal plant Peganum Harmala, which has served as a folk anticancer medicine. Harmine decreased the survival of HepG2 Cells and the cell survival rates were decreased with increasing the compounds concentrations (from 0 to 10 μM). In vivo,the mice receiving 100 mg/kg harmine exhibited neurotoxic behaviors immediately[3].In addition, harmine administration was associated with neuroprotective effects and also improved memory/learning in several animal models[4]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02914769 | Major Depression | Phase 1 Phase 2 | Completed | - | Brazil ... 展开 >> Draulio B de Araujo Natal, Rio Grande do Norte, Brazil, 59012-300 收起 << |
NCT02379767 | - | Unknown | February 2018 | Austria ... 展开 >> Department of Psychiatry and Psychotherapy Recruiting Vienna, Austria, 1090 Contact: Rupert Lanzenberger, Assoc. Prof. PD MD +43-1-40400-35760 rupert.lanzenberger@meduniwien.ac.at 收起 << | |
NCT02715232 | Gender Dysphoria | Phase 4 | Recruiting | December 2020 | Austria ... 展开 >> Department of Psychiatry and Psychotherapy, Medical University of Vienna Recruiting Vienna, Austria, 1090 Contact: Rupert Lanzenberger, A/Prof. +43 40400 ext 3825 rupert.lanzenberger@meduniwien.ac.at Principal Investigator: Rupert Lanzenberger, A/Prof. MD 收起 << |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
4.71mL 0.94mL 0.47mL |
23.56mL 4.71mL 2.36mL |
47.11mL 9.42mL 4.71mL |
CAS号 | 442-51-3 |
分子式 | C13H12N2O |
分子量 | 212.247 |
别名 | 哈尔碱 ;Telepathine |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 30 mg/mL(141.34 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |