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去氢骆驼蓬碱 /Harmine {[allProObj[0].p_purity_real_show]}

货号：A350584 同义名： 哈尔碱 / Telepathine

Harmine是一种天然的双特异性酪氨酸磷酸化调节激酶（DYRK）抑制剂，具有抗癌和抗炎活性。它对5-HT2A血清素受体具有高亲和力，Ki值为397 nM。

Harmine 化学结构 CAS号：442-51-3
Harmine 化学结构
CAS号：442-51-3
Harmine 3D分子结构
CAS号：442-51-3
Harmine 化学结构 CAS号：442-51-3
Harmine 3D分子结构 CAS号：442-51-3
规格 价格 会员价 库存 数量
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Harmine 纯度/质量文件 产品仅供科研

货号：A350584 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 MAO ↓ MAO-A ↓ MAO-B ↓ 其他靶点 纯度
Sennoside A ++

MAO, IC50: 17 μM

 		98%+
Glycyrrhizic acid ++++

MAO, IC50: 0.16 μM

 		80% HPLC
Rasagiline ++++

MAO-A, IC50: 412 nM

 		++++

MAO-B, IC50: 4.43 nM

 		99+%
Isatin ++

MAO, IC50: 15 μM

 		+

MAO-A, IC50: 58 μM

 		++

MAO-B, IC50: 14 μM

 		98%
Paeonol +

MAO-A, IC50: 54.6 μM

 		+

MAO-B, IC50: 42.5 μM

 		98%
Tranylcypromine hydrochloride +++

MAO-A, IC50: 11.5 μM

 		+++

MAO-B, IC50: 7 μM

 		97%
Moclobemide +++

MAO-A (5-HT), IC50: 6.1 μM

 		99%+
Pargyline HCl ++

MAO-A, Ki: 13 μM

 		+++

MAO-B, Ki: 0.5 μM

 		99%+
Safinamide ++++

MAO-B, IC50: 98 nM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Harmine 生物活性

靶点

  • DYRK1

    DYRK1B, IC50:166 nM

    DYRK1A, IC50:33 nM

  • DYRK2

    DYRK2, IC50:1.9 μM
描述 Harmine is a beta-carboline alkaloid found in medicinal plant Peganum Harmala, which has served as a folk anticancer medicine. Harmine decreased the survival of HepG2 Cells and the cell survival rates were decreased with increasing the compounds concentrations (from 0 to 10 μM). In vivo,the mice receiving 100 mg/kg harmine exhibited neurotoxic behaviors immediately[3].In addition, harmine administration was associated with neuroprotective effects and also improved memory/learning in several animal models[4].

Harmine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02914769 Major Depression Phase 1 Phase 2 Completed - Brazil ... 展开 >> Draulio B de Araujo Natal, Rio Grande do Norte, Brazil, 59012-300 收起 <<
NCT02379767 - Unknown February 2018 Austria ... 展开 >> Department of Psychiatry and Psychotherapy Recruiting Vienna, Austria, 1090 Contact: Rupert Lanzenberger, Assoc. Prof. PD MD    +43-1-40400-35760    rupert.lanzenberger@meduniwien.ac.at 收起 <<
NCT02715232 Gender Dysphoria Phase 4 Recruiting December 2020 Austria ... 展开 >> Department of Psychiatry and Psychotherapy, Medical University of Vienna Recruiting Vienna, Austria, 1090 Contact: Rupert Lanzenberger, A/Prof.    +43 40400 ext 3825    rupert.lanzenberger@meduniwien.ac.at    Principal Investigator: Rupert Lanzenberger, A/Prof. MD 收起 <<

Harmine 参考文献

[1]Chen D, Su A, et al. Harmine blocks herpes simplex virus infection through downregulating cellular NF-κB and MAPK pathways induced by oxidative stress. Antiviral Res. 2015 Nov;123:27-38.

[2]Zhang H, Sun K, et al. Harmine induces apoptosis and inhibits tumor cell proliferation, migration and invasion through down-regulation of cyclooxygenase-2 expression in gastric cancer. Phytomedicine. 2014 Feb 15;21(3):348-55.

[3]Li S, Wang A, Gu F, Wang Z, Tian C, Qian Z, Tang L, Gu Y. Novel harmine derivatives for tumor targeted therapy. Oncotarget. 2015 Apr 20;6(11):8988-9001. doi: 10.18632/oncotarget.3276. PMID: 25940702; PMCID: PMC4496197.

[4]Dos Santos RG, Hallak JE. Effects of the Natural β-Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus: A Systematic Literature Review of Preclinical Studies. J Psychoactive Drugs. 2017 Jan-Mar;49(1):1-10. doi: 10.1080/02791072.2016.1260189. Epub 2016 Dec 5. PMID: 27918874.

Harmine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.71mL

0.94mL

0.47mL

23.56mL

4.71mL

2.36mL

47.11mL

9.42mL

4.71mL

Harmine 技术信息

CAS号442-51-3
分子式C13H12N2O
分子量 212.247
别名 哈尔碱 ;Telepathine
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature
溶解度

DMSO: 30 mg/mL(141.34 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Harmine | Telepathine | 哈尔碱 | MAO | AmBeed-信号通路专用抑制剂 | Harmine 纯度/质量文件 | Harmine 亚型比较 | Harmine 生物活性 | Harmine 临床数据 | Harmine 参考文献 | Harmine 实验方案 | Harmine 技术信息

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