Harmine | Telepathine | 哈尔碱 | MAO | AmBeed-信号通路专用抑制剂

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去氢骆驼蓬碱 /Harmine 99%+

货号：A350584 同义名： 哈尔碱 / Telepathine

Harmine是一种天然的双特异性酪氨酸磷酸化调节激酶（DYRK）抑制剂，具有抗癌和抗炎活性。它对5-HT2A血清素受体具有高亲和力，Ki值为397 nM。

Harmine 化学结构
CAS号：442-51-3

Harmine 3D分子结构
CAS号：442-51-3

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Harmine 纯度/质量文件产品仅供科研

货号：A350584 标准纯度： 99%+ 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024. Ambeed. [ A288696 ]; • JMC, 2024. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

MAO 亚型比较

产品名称	MAO ↓ ↑	MAO-A ↓ ↑	MAO-B ↓ ↑	纯度
Sennoside A	++ MAO, IC50: 17 μM			99%+
Glycyrrhizic acid	++++ MAO, IC50: 0.16 μM			80% HPLC
Rasagiline		++++ MAO-A, IC50: 412 nM	++++ MAO-B, IC50: 4.43 nM	99+%
Isatin	++ MAO, IC50: 15 μM	+ MAO-A, IC50: 58 μM	++ MAO-B, IC50: 14 μM	99%+
Paeonol		+ MAO-A, IC50: 54.6 μM	+ MAO-B, IC50: 42.5 μM	99%+
Tranylcypromine hydrochloride		+++ MAO-A, IC50: 11.5 μM	+++ MAO-B, IC50: 7 μM	99%+
Moclobemide		+++ MAO-A (5-HT), IC50: 6.1 μM		99%+
Pargyline HCl		++ MAO-A, Ki: 13 μM	+++ MAO-B, Ki: 0.5 μM	99%+
Safinamide			++++ MAO-B, IC50: 98 nM	99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Harmine 生物活性

靶点

DYRK1

DYRK1A, IC50:33 nM

DYRK1B, IC50:166 nM
DYRK2

DYRK2, IC50:1.9 μM

描述

Harmine is a beta-carboline alkaloid found in medicinal plant Peganum Harmala, which has served as a folk anticancer medicine. Harmine decreased the survival of HepG2 Cells and the cell survival rates were decreased with increasing the compounds concentrations (from 0 to 10 μM). In vivo,the mice receiving 100 mg/kg harmine exhibited neurotoxic behaviors immediately^[3].In addition, harmine administration was associated with neuroprotective effects and also improved memory/learning in several animal models^[4].

Harmine 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02914769	Major Depression	Phase 1 Phase 2	Completed	-	Brazil ... 展开 >> Draulio B de Araujo Natal, Rio Grande do Norte, Brazil, 59012-300 收起 <<
NCT02379767	-		Unknown	February 2018	Austria ... 展开 >> Department of Psychiatry and Psychotherapy Recruiting Vienna, Austria, 1090 Contact: Rupert Lanzenberger, Assoc. Prof. PD MD +43-1-40400-35760 rupert.lanzenberger@meduniwien.ac.at 收起 <<
NCT02715232	Gender Dysphoria	Phase 4	Recruiting	December 2020	Austria ... 展开 >> Department of Psychiatry and Psychotherapy, Medical University of Vienna Recruiting Vienna, Austria, 1090 Contact: Rupert Lanzenberger, A/Prof. +43 40400 ext 3825 rupert.lanzenberger@meduniwien.ac.at Principal Investigator: Rupert Lanzenberger, A/Prof. MD 收起 <<

Harmine 参考文献

[1]Chen D, Su A, et al. Harmine blocks herpes simplex virus infection through downregulating cellular NF-κB and MAPK pathways induced by oxidative stress. Antiviral Res. 2015 Nov;123:27-38.

[2]Zhang H, Sun K, et al. Harmine induces apoptosis and inhibits tumor cell proliferation, migration and invasion through down-regulation of cyclooxygenase-2 expression in gastric cancer. Phytomedicine. 2014 Feb 15;21(3):348-55.

[3]Li S, Wang A, Gu F, Wang Z, Tian C, Qian Z, Tang L, Gu Y. Novel harmine derivatives for tumor targeted therapy. Oncotarget. 2015 Apr 20;6(11):8988-9001. doi: 10.18632/oncotarget.3276. PMID: 25940702; PMCID: PMC4496197.

[4]Dos Santos RG, Hallak JE. Effects of the Natural β-Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus: A Systematic Literature Review of Preclinical Studies. J Psychoactive Drugs. 2017 Jan-Mar;49(1):1-10. doi: 10.1080/02791072.2016.1260189. Epub 2016 Dec 5. PMID: 27918874.

Harmine 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

4.71mL

0.94mL

0.47mL

23.56mL

4.71mL

2.36mL

47.11mL

9.42mL

4.71mL

Harmine 技术信息

CAS号	442-51-3
分子式	C₁₃H₁₂N₂O
分子量	212.247

别名	哈尔碱 ;Telepathine
运输	蓝冰

存储条件

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 30 mg/mL(141.34 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02914769	Major Depression	Phase 1 Phase 2	Completed	-	Brazil ... 展开 >> Draulio B de Araujo Natal, Rio Grande do Norte, Brazil, 59012-300 收起 <<
NCT02379767	-		Unknown	February 2018	Austria ... 展开 >> Department of Psychiatry and Psychotherapy Recruiting Vienna, Austria, 1090 Contact: Rupert Lanzenberger, Assoc. Prof. PD MD +43-1-40400-35760 rupert.lanzenberger@meduniwien.ac.at 收起 <<
NCT02715232	Gender Dysphoria	Phase 4	Recruiting	December 2020	Austria ... 展开 >> Department of Psychiatry and Psychotherapy, Medical University of Vienna Recruiting Vienna, Austria, 1090 Contact: Rupert Lanzenberger, A/Prof. +43 40400 ext 3825 rupert.lanzenberger@meduniwien.ac.at Principal Investigator: Rupert Lanzenberger, A/Prof. MD 收起 <<

去氢骆驼蓬碱 /Harmine 99%+

Harmine 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Harmine 质控信息

Harmine 生物活性

Harmine 临床研究

Harmine 参考文献

Harmine 实验方案

Harmine 技术信息

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DYRK1	DYRK1A, IC50:33 nM DYRK1B, IC50:166 nM
DYRK2	DYRK2, IC50:1.9 μM

去氢骆驼蓬碱 /Harmine 99%+

Harmine 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Harmine 质控信息

Harmine 生物活性

Harmine 临床研究

Harmine 参考文献

Harmine 实验方案

Harmine 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Harmine 纯度/质量文件产品仅供科研