货号:A646979
同义名:
Flagecidin;Wuningmeisu C
Anisomycin is a naturally occuring antibiotic which can act as a potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAPK, and also can inhibit protein synthesis by blocking translation.
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产品名称 | JNK ↓ ↑ | JNK1 ↓ ↑ | JNK2 ↓ ↑ | JNK3 ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mulberroside A | ✔ | 99%+ | |||||||||||||||||
Loureirin B | ✔ | Calcium Channel,Potassium Channel | 99%+ | ||||||||||||||||
Ginsenoside Re | ✔ | NF-κB | 98% | ||||||||||||||||
(+)-(3R,8S)-Falcarindiol | ✔ | ERK,STAT | 99%+ | ||||||||||||||||
trans-Zeatin | ✔ | p38 MAPK,ERK | 95+% | ||||||||||||||||
Urolithin B | ✔ | ERK,NF-κB | 99%+ | ||||||||||||||||
Cucurbitacin IIb | ✔ | NF-κB | 99%+ | ||||||||||||||||
Astragaloside IV | ✔ | Akt,NF-κB,mTOR | 98% | ||||||||||||||||
NDMC101 | ✔ | 99%+ | |||||||||||||||||
DB07268 |
++++
JNK1, IC50: 9 nM |
99%+ | |||||||||||||||||
SP600125 |
+
MKK4, IC50: 0.4 μM |
+++
JNK1, IC50: 40 nM |
+++
JNK2, IC50: 40 nM |
+++
JNK3, IC50: 90 nM |
98% | ||||||||||||||
JNK-IN-7 |
++++
JNK1, IC50: 1.5 nM |
++++
JNK2, IC50: 2 nM |
++++
JNK3, IC50: 0.7 nM |
99%+ | |||||||||||||||
JNK-IN-8 |
++++
JNK1, IC50: 4.7 nM |
+++
JNK2, IC50: 18.7 nM |
++++
JNK3, IC50: 1 nM |
99%+ | |||||||||||||||
3,3',5-Triiodo-L-thyronine |
++
JNK1, Kd: 240 nM |
++
JNK2, Kd: 290 nM |
+++
JNK3, Kd: 66 nM |
99%+ | |||||||||||||||
IQ-1S free acid |
+
JNK1, IC50: 390 nM |
++
JNK2, IC50: 360 nM |
+++
JNK3, IC50: 87 nM |
98% | |||||||||||||||
BI-78D3 |
++
JNK, IC50: 280 nM |
++
JNK, IC50: 280 nM |
++
JNK, IC50: 280 nM |
++
JNK, IC50: 280 nM |
99%+ | ||||||||||||||
Bentamapimod |
+++
JNK1, IC50: 80 nM |
+++
JNK2, IC50: 90 nM |
++
JNK3, IC50: 230 nM |
99%+ | |||||||||||||||
Resveratrol |
+
JNK1, IC50: 50 μM |
98% | |||||||||||||||||
Indirubin-3′-oxime | ✔ | 99%+ | |||||||||||||||||
SU3327 |
+
JNK, IC50: 0.7 μM |
+
JNK, IC50: 0.7 μM |
+
JNK, IC50: 0.7 μM |
+
JNK, IC50: 0.7 μM |
99%+ | ||||||||||||||
JNK Inhibitor VIII |
++++
JNK1, Ki: 2 nM JNK1, IC50: 45 nM |
++++
JNK2, IC50: 160 nM JNK2, Ki: 4 nM |
+++
JNK3, Ki: 52 nM |
99%+ | |||||||||||||||
Doramapimod | ✔ | 99%+ | |||||||||||||||||
RPI-1 | ✔ | 99%+ | |||||||||||||||||
TCS JNK 5a |
++
JNK2, pIC50: 6.5 |
++
JNK3, pIC50: 6.7 |
99%+ | ||||||||||||||||
SP 600125, negative control |
+
JNK2, IC50: 18 μM |
+
JNK3, IC50: 24 μM |
97% | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinases (MAPK) family. Anisomycin is an activator of both JNK and p38[3]. The incubation of HL-1 myocytes with 50ng/mL anisomycin for 24 h markedly increased the protein level of CaMKIIδ by ∼60% relative to the control group. The c-jun phosphorylation in total cell lysates and nuclear extracts was also increased by the treatment of 50ng/mL HL-1 myocytes with anisomycin for 24 h[4]. The intraperitoneal injection of wild-type, TNFR p55/p75-/-, and Nox2-/- mice with 0.1mg/kg anisomycin resulted in the activation of p38, an increase in the production of TNF-α and Nox2, and the phosphorylation of Nox2 compared with the control group[5]. |
细胞系 | 浓度 | 检测类型 | 检测时间 | 活动说明 | 数据源 |
HEK293 cells | Cytotoxic assay | Inhibitory concentration required to produce cytotoxicity against HEK293 cells, IC50=0.02 μM | 16005213 | ||
human HeLa cells | 10 μM | Function assay | Inhibition of translation in human HeLa cells at 10 uM by 35S-methionine metabolic labeling study | 15165136 | |
mouse RAW264.7 cells | 5 μM | Function assay | 30 mins | Activation of p38MAPK in mouse RAW264.7 cells assessed as phosphorylation at Thr180/Tyr182 at 5 uM after 30 mins by Western blotting analysis | 23294286 |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.77mL 0.75mL 0.38mL |
18.85mL 3.77mL 1.88mL |
37.69mL 7.54mL 3.77mL |
CAS号 | 22862-76-6 |
分子式 | C14H19NO4 |
分子量 | 265.305 |
别名 | Flagecidin;Wuningmeisu C;AI3-50846;NSC 76712 |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 50 mg/mL(188.46 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 4 mg/mL(15.08 mM),配合低频超声,并水浴加热至45℃助溶 |
动物实验配方 |
2% DMSO+corn oil 5 mg/mL |