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/ Ambroxol HCl

盐酸氨溴索 /Ambroxol HCl {[allProObj[0].p_purity_real_show]}

货号：A118627 同义名： NA-872 hydrochloride;Ambroxol hydrochloride

Ambroxol HCl是一种神经 Na+ 通道的抑制剂，以 IC50 分别为 35.2 μM（稳态阻断）/22.5 μM（快速阻断）和 100 μM 抑制 TTX 耐受型和敏感型 Na+ 电流。

Ambroxol HCl 化学结构 CAS号：23828-92-4
Ambroxol HCl 化学结构
CAS号：23828-92-4
Ambroxol HCl 3D分子结构
CAS号：23828-92-4
Ambroxol HCl 化学结构 CAS号：23828-92-4
Ambroxol HCl 3D分子结构 CAS号：23828-92-4
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Ambroxol HCl 纯度/质量文件 产品仅供科研

货号：A118627 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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• bioRxiv, 2025. Ambeed. [ A538667 , A714873 , A126729 , A126049 , A446054 ]
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产品名称 Sodium Channel ↓ 其他靶点 纯度
Tolperisone HCl ✔ 99%
Lamotrigine ✔ 98%
Vinpocetine ✔ 98%
Zonisamide ✔ 99%
Dronedarone Hydrochloride ✔ 95%
Procainamide hydrochloride ✔ 99%
Bupivacaine HCl ✔ 99+%
Benzocaine ✔ 98%
Carbamazepine ++

Sodium channel, IC50: 131 μM

 		98%
Quinidine sulfate dihydrate ✔ 98%
Ibutilide fumarate ✔ 99%+
Dibucaine HCl ✔ 99+%
Mexiletine HCl ✔ 99%
Phenytoin ✔ 99+%
Camostat Mesylate +++

epithelial sodium channel (ENaC), IC50: 50 nM

 		99%+
Levobupivacaine ✔ 97+%
Oxcarbazepine +

sodium channel, IC50: 160 μM

 		98%
Ambroxol 98+%
Primidone ✔ 99%
Propafenone ✔ 99%
A-803467 ++++

Na(V1.8) channel, IC50: 8 nM

 		99%+
Rufinamide ✔ 99%
Phenytoin sodium ✔ 98%
Proparacaine Hydrochloride +

Voltage-gated sodium channel, ED50: 3.4 mM

 		98+%
Riluzole ✔ 97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ambroxol HCl 生物活性

描述 Ambroxol hydrochloride, an active metabolite of the prodrug Bromhexine, has potent expectorant effects[3]. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research. Ambroxol hydrochloride (1, 3, 4, 5 mM for 12 consecutive days in drinking water) results in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing the heterozygous L444P mutation in the murine glucocerebrosidase 1 gene, and transgenic mice overexpressing human α-synuclein[4]. In addition, ambroxol hydrochloride improved motor recovery and muscle re-innervation after transient sciatic nerve injury in non-transgenic mice and promoted axonal elongation in an in vitro model of motor unit[5]. Ambroxol hydrochloride administered intravenously more than 48 hours prior to chemotherapy optimally increased the concentrations of paclitaxel and carboplatin in lung tissue without significantly increasing hematologic toxicity[6].

Ambroxol HCl 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00144274 Pharyngitis Phase 3 Completed - South Africa ... 展开 >> Boehringer Ingelheim Investigational Site Boksburg, South Africa, 1461 Boehringer Ingelheim Investigational Site Cape Town, South Africa, 7646 Boehringer Ingelheim Investigational Site Cape Town, South Africa, 7700 Boehringer Ingelheim Investigational Site Cape Town, South Africa, 7945 Boehringer Ingelheim Investigational Site Durban, South Africa, 4091 Boehringer Ingelheim Investigational Site Johannesburg, South Africa, 2033 Boehringer Ingelheim Investigational Site Johannesburg, South Africa, 2192 Boehringer Ingelheim Investigational Site Krugersdorp, South Africa, 1739 Boehringer Ingelheim Investigational Site Midrand, South Africa, 1685 Boehringer Ingelheim Investigational Site Pretoria, South Africa, 0038 Boehringer Ingelheim Investigational Site Pretoria, South Africa, 0157 Boehringer Ingelheim Investigational Site Sandton, South Africa, 2021 收起 <<
NCT00148499 Pharyngitis Phase 3 Completed - Romania ... 展开 >> Medicover Bucharest, Romania, 010224 Medicover Bucharest, Romania, 010626 Medicover Bucharest, Romania, 021106 Victor Babes Clincial Hospital Bucharest, Romania, 030303 Ukraine Regional Student Hospital Kharkov, Ukraine, 61002 Regional Clinical Hospital Kharkov, Ukraine, 61022 City Clinical Otolaryngological Hospital Kharkov, Ukraine, 61024 City Clinical Hospital No. 17 Kharkov, Ukraine, 61037 City Clinical Hospital No. 11 Kharkov, Ukraine, 61050 City Clinical Hospital No. 26 Kharkov, Ukraine, 61072 Academy of Medical Science named after O.S. Kolomyichenko Kiev, Ukraine, 03057 City Clinical Hospital No. 9 Kiev, Ukraine, 04112 City Clinical Hospital No. 11 Odessa, Ukraine, 65006 Regional Clinical Hospital Zaporozhye, Ukraine, 69600 收起 <<
NCT03583658 Pharyngitis Phase 3 Completed - South Africa ... 展开 >> Investigational Site Number 7100005 Johannesburg, South Africa 收起 <<

Ambroxol HCl 参考文献

[1]Weiser T, Wilson N. Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na(+) channels by the secretolytic ambroxol. Mol Pharmacol. 2002 Sep;62(3):433-8.

[2]Gibbs BF, Schmutzler W, et al. Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inflamm Res. 1999 Feb;48(2):86-93.

[3]Deretic V, Timmins GS. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218

[4]Migdalska-Richards A, Daly L, Bezard E, Schapira AH. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775

[5]Bouscary A, Quessada C, Mosbach A, Callizot N, Spedding M, Loeffler JP, Henriques A. Ambroxol Hydrochloride Improves Motor Functions and Extends Survival in a Mouse Model of Familial Amyotrophic Lateral Sclerosis. Front Pharmacol. 2019 Aug 7;10:883

[6]Li J, Yi W, Jiang P, Sun R, Li T. Effects of ambroxol hydrochloride on concentrations of paclitaxel and carboplatin in lung cancer patients at different administration times. Cell Mol Biol (Noisy-le-grand). 2016 Nov 30;62(13):85-89

Ambroxol HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.06mL

2.41mL

1.21mL

24.12mL

4.82mL

2.41mL

Ambroxol HCl 技术信息

CAS号23828-92-4
分子式C13H19Br2ClN2O
分子量 414.564
别名 NA-872 hydrochloride;Ambroxol hydrochloride;Mucosolvan;Ebromin;Duramucal;Ambro-Puren Ambrobeta;Ambril;Abrohexal;NA 872
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,2-8°C
溶解方案

H2O: 8 mg/mL(19.3 mM)，配合低频超声助溶
动物实验配方

Tags: Ambroxol HCl | Ambroxol hydrochloride | NA-872 hydrochloride;Ambroxol (hydrochloride);Mucosolvan;Ebromin;Duramucal;Ambro-Puren Ambrobeta;Ambril;Abrohexal;NA 872;Ambroxol HCl | Drug Standard | Sodium Channel | AmBeed-信号通路专用抑制剂 | Ambroxol HCl 纯度/质量文件 | Ambroxol HCl 亚型比较 | Ambroxol HCl 生物活性 | Ambroxol HCl 临床数据 | Ambroxol HCl 参考文献 | Ambroxol HCl 实验方案 | Ambroxol HCl 技术信息

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