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3-甲氧基苯甲酰胺 /3-Methoxybenzamide {[allProObj[0].p_purity_real_show]}

货号:A503438 同义名: 3-MBA;m-Methoxybenzamide

3-Methoxybenzamide is a competitive poly(ADP-ribose) synthetase inhibitor with Ki value < 2 μM and also inhibits ADP-ribosyltransferase (ADPRT).

3-Methoxybenzamide 化学结构 CAS号:5813-86-5
3-Methoxybenzamide 化学结构
CAS号:5813-86-5
3-Methoxybenzamide 3D分子结构
CAS号:5813-86-5
3-Methoxybenzamide 化学结构 CAS号:5813-86-5
3-Methoxybenzamide 3D分子结构 CAS号:5813-86-5
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3-Methoxybenzamide 纯度/质量文件 产品仅供科研

货号:A503438 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 PARP PARP1 PARP2 PARP3 其他靶点 纯度
PJ34 HCl ++

PARP, EC50: 20 nM

99%+
Rucaparib phosphate ++++

PARP, Ki: 1.4 nM

99%+
3-Aminobenzamide ++

PARP, IC50: <50 nM

98%
AZD-2461 99%+
BGP-15 99%+
NU1025 +

PARP, IC50: 400 nM

97%
Benzamide +

PARP, IC50: 3.3 μM

98%
Picolinamide +

PARP, IC50: 95 μM

98%
AG14361 +++

PARP1, Ki: <5 nM

98+%
Iniparib 98%
Talazoparib ++++

PARP1, IC50: 0.57 nM

99%+
NMS-P118 ++

PARP1, Kd: 0.009 μM

98+%
UPF 1069 +

PARP1, IC50: 8.0 μM

++

PARP2, IC50: 0.3 μM

98%
A-966492 ++++

PARP1, Ki: 1 nM

PARP1, EC50: 1 nM

+++

PARP2, Ki: 1.5 nM

99%+
Veliparib ++

PARP1, Ki: 5.2 nM

+++

PARP2, Ki: 2.9 nM

98%
Niraparib tosylate +++

PARP1, IC50: 3.8 nM

+++

PARP2, IC50: 2.1 nM

99%+
Stenoparib ++++

PARP1, IC50: 1 nM

++++

PARP2, IC50: 1.2 nM

98%
Olaparib +++

PARP1, IC50: 5 nM

++++

PARP2, IC50: 1 nM

98%
Niraparib +++

PARP1, IC50: 3.8 nM

+++

PARP2, IC50: 2.1 nM

98%
ME0328 +

PARP1, IC50: 6.3 μM

+

PARP3, IC50: 0.89 μM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

3-Methoxybenzamide 生物活性

描述 3-Methoxybenzamide (3-MBA), an inhibitor of ADP-ribosyltransferase, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells. 3-Methoxybenzamide (0-30 mM) affects septation via the FtsZ system during both vegetative growth and sporulation[2]. 3-methoxybenzamide, new inhibitors of the nuclear enzyme poly(ADP-ribose) synthetase, with Ki values or less than 2 microM[3]. 3-Methoxybenzamide (3-MBA) enhances in vitro plant growth, microtuberization, and transformation efficiency of blue potato (Solanum tuberosum L. subsp. andigenum). 3-Methoxybenzamide (3 MB; 0.2 to 0.6 mM) significantly increaseS the growth and microtuber formation of in vitro propagated plants[4]. 3-MB (3-Methoxybenzamide) inhibits illegitimate recombination and has no effect on extrachromosomal homologous recombination in mouse Ltk- cells[5]. Whereas ADP-ribosylation of H2A and H2B is sensitive to inhibition by 3-methoxybenzamide, as with most other nuclear acceptor proteins, the modification of H3 and H4 is not inhibited[6].

3-Methoxybenzamide 参考文献

[1]Purnell MR, Whish WJ. Novel inhibitors of poly(ADP-ribose) synthetase. Biochem J. 1980 Mar 1;185(3):775-7. doi: 10.1042/bj1850775. PMID: 6248035; PMCID: PMC1161458.

[2]Ohashi Y, Chijiiwa Y, Suzuki K, Takahashi K, Nanamiya H, Sato T, Hosoya Y, Ochi K, Kawamura F. The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis. J Bacteriol. 1999 Feb;181(4):1348-51

[3]Purnell MR, Whish WJ. Novel inhibitors of poly(ADP-ribose) synthetase. Biochem J. 1980 Mar 1;185(3):775-7

[4]Poly (ADP-ribose) polymerase inhibitor 3-methoxybenzamide enhances in vitro plant growth, microtuberization, and transformation efficiency of blue potato (Solanum tuberosum L. subsp. andigenum)

[5]Waldman AS, Waldman BC. Stimulation of intrachromosomal homologous recombination in mammalian cells by an inhibitor of poly(ADP-ribosylation). Nucleic Acids Res. 1991 Nov 11;19(21):5943-7

[6]Golderer G, Gröbner P. ADP-ribosylation of core histones and their acetylated subspecies. Biochem J. 1991 Aug 1;277 ( Pt 3)(Pt 3):607-10

3-Methoxybenzamide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.62mL

1.32mL

0.66mL

33.08mL

6.62mL

3.31mL

66.15mL

13.23mL

6.62mL

3-Methoxybenzamide 技术信息

CAS号5813-86-5
分子式C8H9NO2
分子量 151.163
别名 3-MBA;m-Methoxybenzamide;NSC 209527;NSC 28589;meta-Methoxybenzamide;m-Anisamide
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度

DMSO: 105 mg/mL(694.62 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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