Benzamide | Benzenecarboxamide;Phenylamide | PARP | AmBeed-信号通路专用抑制剂

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苯甲酰胺 /Benzamide {[allProObj[0].p_purity_real_show]}

货号：A446394 同义名： Benzenecarboxamide;Phenylamide

Benzamide, an inhibitor of poly (ADP-ribose) polymerase, is a derivative of benzoic acid.

Benzamide 化学结构
CAS号：55-21-0

Benzamide 3D分子结构
CAS号：55-21-0

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Benzamide 纯度/质量文件产品仅供科研

货号：A446394 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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PARP 亚型比较

产品名称	PARP ↓ ↑	PARP1 ↓ ↑	PARP2 ↓ ↑	PARP3 ↓ ↑	纯度
PJ34 HCl	++ PARP, EC50: 20 nM				99%+
Rucaparib phosphate	++++ PARP, Ki: 1.4 nM				99%+
3-Aminobenzamide	++ PARP, IC50: <50 nM				98%
AZD-2461	✔				99%+
BGP-15	✔				99%+
NU1025	+ PARP, IC50: 400 nM				97%
Benzamide	+ PARP, IC50: 3.3 μM				98%
Picolinamide	+ PARP, IC50: 95 μM				98%
AG14361		+++ PARP1, Ki: <5 nM			98+%
Iniparib		✔			98%
Talazoparib		++++ PARP1, IC50: 0.57 nM			99%+
NMS-P118		++ PARP1, Kd: 0.009 μM			98+%
UPF 1069		+ PARP1, IC50: 8.0 μM	++ PARP2, IC50: 0.3 μM		98%
A-966492		++++ PARP1, Ki: 1 nM PARP1, EC50: 1 nM	+++ PARP2, Ki: 1.5 nM		99%+
Veliparib		++ PARP1, Ki: 5.2 nM	+++ PARP2, Ki: 2.9 nM		98%
Niraparib tosylate		+++ PARP1, IC50: 3.8 nM	+++ PARP2, IC50: 2.1 nM		99%+
Stenoparib		++++ PARP1, IC50: 1 nM	++++ PARP2, IC50: 1.2 nM		98%
Olaparib		+++ PARP1, IC50: 5 nM	++++ PARP2, IC50: 1 nM		98%
Niraparib		+++ PARP1, IC50: 3.8 nM	+++ PARP2, IC50: 2.1 nM		98%
ME0328		+ PARP1, IC50: 6.3 μM		+ PARP3, IC50: 0.89 μM	99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Benzamide 生物活性

靶点

PARP

PARP, IC50:3.3 μM

描述

Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature. Benzamide (160 mg/kg; IP, 2 injection by a 4 h interval) attenuates the METH-induced dopamine depletions. Benzamide (160 mg/kg; IP, single dosage) has no acute effect on striatal dopamine metabolism and does not reduce body temperature^[3].

Benzamide 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01636947	Nausea Vomiti... 展开 >>ng 收起 <<	Phase 4	Completed	-	-
NCT01636947	-		Completed	-	-
NCT00080444	Vomiting	Phase 3	Completed	-	-

Benzamide 参考文献

[1]Wang XY, Lim-Jurado M, et al. Treatment of allergic rhinitis and urticaria: a review of the newest antihistamine drug bilastine. Ther Clin Risk Manag. 2016 Apr 13;12:585-97.

[2]Kun E, Kirsten E, et al. Cell cycle-dependent intervention by benzamide of carcinogen-induced neoplastic transformation and in vitro poly(ADP-tibosyl)ation of nuclear proteins in human fibroblasts. Proc Natl Acad Sci U S A. 1983 Dec;80(23):7219-23.

[3]Cosi C, Chopin P, Marien M. Benzamide, an inhibitor of poly(ADP-ribose) polymerase, attenuates methamphetamine-induced dopamine neurotoxicity in the C57B1/6N mouse. Brain Res. 1996;735(2):343-348.

Benzamide 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

8.26mL

1.65mL

0.83mL

41.28mL

8.26mL

4.13mL

82.55mL

16.51mL

8.26mL

Benzamide 技术信息

CAS号	55-21-0
分子式	C₇H₇NO
分子量	121.137

别名	Benzenecarboxamide;Phenylamide
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度

DMSO: 115 mg/mL(949.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01636947	Nausea Vomiti... 展开 >>ng 收起 <<	Phase 4	Completed	-	-
NCT01636947	-		Completed	-	-
NCT00080444	Vomiting	Phase 3	Completed	-	-
NCT02530437	Gastroesophageal Junction Aden... 展开 >>ocarcinoma Stage IB Esophageal Adenocarcinoma AJCC v7 Stage II Esophageal Adenocarcinoma AJCC v7 Stage IIA Esophageal Adenocarcinoma AJCC v7 Stage IIB Esophageal Adenocarcinoma AJCC v7 Stage IIIA Esophageal Adenocarcinoma AJCC v7 Stage IIIB Esophageal Adenocarcinoma AJCC v7 收起 <<	Phase 1 Phase 2	Active, not recruiting	March 31, 2023	United States, Texas ... 展开 >> M D Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT01161836	Advanced Solid Tumors	Phase 1	Completed	-	United States, Washington ... 展开 >> Northwest Medical Specialties Tacoma, Washington, United States, 98405 收起 <<
NCT02542787	Spasticity in People With Mult... 展开 >>iple Sclerosis 收起 <<	Phase 2	Completed	-	United Kingdom ... 展开 >> The Neuroscience Research Centre, The Walton Centre NHS Foundation Trust Liverpool, United Kingdom, L9 7LJ The Royal London Hospital London, United Kingdom, E1 1BB The National Hospital for Neurology and Neurosurgery London, United Kingdom, WC1N 3BG Royal Hallamshire Hospital, Sheffield Teaching Hospital NHS Foundation Trust Sheffield, United Kingdom, S10 2JFS 收起 <<
NCT00875407	Chromaffin-tissue Derived Tumo... 展开 >>rs 收起 <<	Not Applicable	Completed	-	France ... 展开 >> Assistance Publique-Hopitaux de Marseille Marseille, France 收起 <<
NCT02993991	Squamous Cell Carcinoma, Head ... 展开 >>And Neck Squamous Cell Carcinoma Mouth Resectable Squamous Cell Carcinoma of Oral Cavity 收起 <<	Phase 1	Withdrawn(The study has been t... 展开 >>erminated due to a change in internal prioritization and not due to any safety concerns.) 收起 <<	-	Canada, Ontario ... 展开 >> Princess Margaret Cancer Centre Toronto, Ontario, Canada, M5G 2M9 收起 <<
NCT01213381	Advance Solid Tumors	Phase 1	Completed	-	Japan ... 展开 >> Sanofi-Aventis Investigational Site Number 392001 Kobe-Shi, Japan Sanofi-Aventis Investigational Site Number 392002 Matsuyama-Shi, Japan 收起 <<
NCT01594749	-		Completed	-	-
NCT03670173	Multiple Myeloma	Phase 1 Phase 2	Not yet recruiting	September 30, 2020	-
NCT02222220	Clozapine-induced Hypersalivat... 展开 >>ion 收起 <<	Phase 3	Completed	-	Israel ... 展开 >> Be'er Sheva Mental Health Center, Be'er Sheva, Israel, 8417000 收起 <<
NCT00534573	Clozapine-induced Hypersalivat... 展开 >>ion 收起 <<	Phase 3	Completed	-	Israel ... 展开 >> Be'er Sheva Mental Health Center, Tirat HaKarmel Mental Health Center Be'er Sheva, Haifa, Israel 收起 <<
NCT01594749	Chemotherapy-Induced Nausea an... 展开 >>d Vomiting (CINV) 收起 <<	Phase 3	Completed	-	-

苯甲酰胺 /Benzamide {[allProObj[0].p_purity_real_show]}

Benzamide 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Benzamide 质控信息

Benzamide 生物活性

Benzamide 临床研究

Benzamide 参考文献

Benzamide 实验方案

Benzamide 技术信息

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苯甲酰胺 /Benzamide {[allProObj[0].p_purity_real_show]}

Benzamide 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Benzamide 质控信息

Benzamide 生物活性

Benzamide 临床研究

Benzamide 参考文献

Benzamide 实验方案

Benzamide 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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