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3-Methoxybenzamide

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Chemical Structure| 5813-86-5 同义名 : 3-MBA;m-Methoxybenzamide;NSC 209527;NSC 28589;meta-Methoxybenzamide;m-Anisamide
CAS号 : 5813-86-5
货号 : A503438
分子式 : C8H9NO2
纯度 : 98%
分子量 : 151.163
MDL号 : MFCD00007986
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(694.62 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 3-Methoxybenzamide (3-MBA), an inhibitor of ADP-ribosyltransferase, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells. 3-Methoxybenzamide (0-30 mM) affects septation via the FtsZ system during both vegetative growth and sporulation[2]. 3-methoxybenzamide, new inhibitors of the nuclear enzyme poly(ADP-ribose) synthetase, with Ki values or less than 2 microM[3]. 3-Methoxybenzamide (3-MBA) enhances in vitro plant growth, microtuberization, and transformation efficiency of blue potato (Solanum tuberosum L. subsp. andigenum). 3-Methoxybenzamide (3 MB; 0.2 to 0.6 mM) significantly increaseS the growth and microtuber formation of in vitro propagated plants[4]. 3-MB (3-Methoxybenzamide) inhibits illegitimate recombination and has no effect on extrachromosomal homologous recombination in mouse Ltk- cells[5]. Whereas ADP-ribosylation of H2A and H2B is sensitive to inhibition by 3-methoxybenzamide, as with most other nuclear acceptor proteins, the modification of H3 and H4 is not inhibited[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.62mL

1.32mL

0.66mL

33.08mL

6.62mL

3.31mL

66.15mL

13.23mL

6.62mL
参考文献

[1]Purnell MR, Whish WJ. Novel inhibitors of poly(ADP-ribose) synthetase. Biochem J. 1980 Mar 1;185(3):775-7. doi: 10.1042/bj1850775. PMID: 6248035; PMCID: PMC1161458.

[2]Ohashi Y, Chijiiwa Y, Suzuki K, Takahashi K, Nanamiya H, Sato T, Hosoya Y, Ochi K, Kawamura F. The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis. J Bacteriol. 1999 Feb;181(4):1348-51

[3]Purnell MR, Whish WJ. Novel inhibitors of poly(ADP-ribose) synthetase. Biochem J. 1980 Mar 1;185(3):775-7

[4]Poly (ADP-ribose) polymerase inhibitor 3-methoxybenzamide enhances in vitro plant growth, microtuberization, and transformation efficiency of blue potato (Solanum tuberosum L. subsp. andigenum)

[5]Waldman AS, Waldman BC. Stimulation of intrachromosomal homologous recombination in mammalian cells by an inhibitor of poly(ADP-ribosylation). Nucleic Acids Res. 1991 Nov 11;19(21):5943-7

[6]Golderer G, Gröbner P. ADP-ribosylation of core histones and their acetylated subspecies. Biochem J. 1991 Aug 1;277 ( Pt 3)(Pt 3):607-10