Ambeed.cn

首页 / / / PARP / 3-Aminobenzamide

3-氨基苯甲酰胺 /3-Aminobenzamide {[allProObj[0].p_purity_real_show]}

货号:A397911 同义名: PARP-IN-1;3-(Aminocarbonyl) Aniline

INO-1001 is a potent inhibitor of PARP with IC50 of < 50 nM in CHO cells and a mediator of oxidant-induced myocyte dysfunction during reperfusion.

3-Aminobenzamide 化学结构 CAS号:3544-24-9
3-Aminobenzamide 化学结构
CAS号:3544-24-9
3-Aminobenzamide 3D分子结构
CAS号:3544-24-9
3-Aminobenzamide 化学结构 CAS号:3544-24-9
3-Aminobenzamide 3D分子结构 CAS号:3544-24-9
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

3-Aminobenzamide 纯度/质量文件 产品仅供科研

货号:A397911 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

全球学术期刊中引用的产品

Cell Host Microbe, 2024. Ambeed. [ A163338 ]
Cancer Res., 2024. Ambeed. [ A295334 ]
J. Pharm. Investig., 2024. Ambeed. [ A221527 , A691302 , A272538 , A187261 ]
J. Fungi, 2024, 10(11): 751. Ambeed. [ A796919 ]
JBC, 2024, 107935. Ambeed. [ A194396 ]
更多 >
产品名称 PARP PARP1 PARP2 PARP3 其他靶点 纯度
PJ34 HCl ++

PARP, EC50: 20 nM

99%+
Rucaparib phosphate ++++

PARP, Ki: 1.4 nM

99%+
3-Aminobenzamide ++

PARP, IC50: <50 nM

98%
AZD-2461 99%+
BGP-15 99%+
NU1025 +

PARP, IC50: 400 nM

97%
Benzamide +

PARP, IC50: 3.3 μM

98%
Picolinamide +

PARP, IC50: 95 μM

98%
AG14361 +++

PARP1, Ki: <5 nM

98+%
Iniparib 98%
Talazoparib ++++

PARP1, IC50: 0.57 nM

99%+
NMS-P118 ++

PARP1, Kd: 0.009 μM

98+%
UPF 1069 +

PARP1, IC50: 8.0 μM

++

PARP2, IC50: 0.3 μM

98%
A-966492 ++++

PARP1, EC50: 1 nM

PARP1, Ki: 1 nM

+++

PARP2, Ki: 1.5 nM

99%+
Veliparib ++

PARP1, Ki: 5.2 nM

+++

PARP2, Ki: 2.9 nM

98%
Niraparib tosylate +++

PARP1, IC50: 3.8 nM

+++

PARP2, IC50: 2.1 nM

99%+
Stenoparib ++++

PARP1, IC50: 1 nM

++++

PARP2, IC50: 1.2 nM

98%
Olaparib +++

PARP1, IC50: 5 nM

++++

PARP2, IC50: 1 nM

98%
Niraparib +++

PARP1, IC50: 3.8 nM

+++

PARP2, IC50: 2.1 nM

98%
ME0328 +

PARP1, IC50: 6.3 μM

+

PARP3, IC50: 0.89 μM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

3-Aminobenzamide 生物活性

靶点
  • PARP

    PARP, IC50:<50 nM

描述 The nuclear enzyme poly(ADP-ribose) polymerase (PARP) plays an important role in the repair of DNA strand breaks, including those induced by radiation, thus making it a potential target for radiosensitizers. INO-1001 is a novel and potent inhibitor of PARP. INO-1001 at a concentration of 0.05 μM resulted in approximately 50% inhibition of PARP activity in CHO cells after 30 minutes treatment. And concentrations of 1 μM or greater resulted in more than 95% inhibition of the enzyme. Exponentially growing CHO cells were treated with 10 μM INO-1001 starting 30 min. prior to irradiation. INO-1001 significantly sensitized CHO cells to radiation. The initial slope of the survival curve for drug treated and irradiated cultures was greater than radiation alone. The enhancement ratio (ER) at 10% survival was 1.6. A similar radiosensitizing effect was observed in a murine tumor cell line with an ER of 1.7. The fibroblasts were also sensitized by the drug treatment with an ER of 1.4[2]. Immediately after CCI (controlled cortical impact) or sham-injury mice received either INO-1001 (1.6 mg/kg) or vehicle via intracerebral injection (5 microl over 5 min) in a randomized fashion. Local treatment with INO-1001 preserved brain NAD+ levels 2 h after CCI. In the Morris water maze, treatment with INO-1001 reduced the latency to find the hidden platform and increased the time spent in the target quadrant versus vehicle after CCI[3].

3-Aminobenzamide 参考文献

[1]Radovits T, Lin LN, et al. Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. Eur J Pharmacol. 2007 Jun 14;564(1-3):158-66.

[2]Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase

[3] Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice

3-Aminobenzamide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

7.34mL

1.47mL

0.73mL

36.72mL

7.34mL

3.67mL

73.45mL

14.69mL

7.34mL

3-Aminobenzamide 技术信息

CAS号3544-24-9
分子式C7H8N2O
分子量 136.15
别名 PARP-IN-1;3-(Aminocarbonyl) Aniline;3-Carboxamidoaniline;3-AB;3-ABA
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

H2O: 10 mg/mL(73.45 mM)

动物实验配方
Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
  • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务,不为任何个人或者非科研性质用途提供服务。