Picolinamide
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货号：A226558
同义名：
2-吡啶甲酰胺
/ 2-Picolinamide; 2-Pyridinecarboxamide
Picolinamide 是一种强效抑制大鼠胰腺岛细胞核内聚（ADP-核糖）合成酶的抑制剂。
Picolinamide 化学结构
Picolinamide 3D分子结构
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Picolinamide 纯度/质量文件 产品仅供科研
货号：A226558
标准纯度：
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产品说明书
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Picolinamide 质控信息
Picolinamide 生物活性
靶点
描述
Picolinamide was found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells[3] [4] [5]
Picolinamide 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT03033485
Melanoma
Not Applicable
Not yet recruiting
December 2018
China, Shaanxi
... 展开 >> Xijing Hospital Nuclear Medicine Department
Xi'an, Shaanxi, China, 710032 收起 <<
Picolinamide 参考文献
[1] Campbell PI, al-Mahrouq HA, et al. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. J Pharmacol Exp Ther. 1989 Oct;251(1):188-92.
[2] Orpin CG, Knight M, Evans WC. The bacterial oxidation of picolinamide, a photolytic product of Diquat. Biochem J. 1972 May;127(5):819-31.
[3] Uchigata Y, Yamamoto H, Kawamura A, Okamoto H. Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem. 1982;257(11):6084-6088.
[4] Campbell PI, al-Mahrouq HA, Abraham MI, Kempson SA. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. J Pharmacol Exp Ther. 1989;251(1):188-192.
[5] Yamagami T, Miwa A, Takasawa S, Yamamoto H, Okamoto H. Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors. Cancer Res. 1985;45(4):1845-1849.
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Picolinamide 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
8.19mL
1.64mL
0.82mL
40.94mL
8.19mL
4.09mL
81.89mL
16.38mL
8.19mL
Picolinamide 技术信息
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