BGP-15, is a nicotinic amidoxime derivative withPARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury.
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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Poly(ADP-ribose) polymerase-1 (PARP1) and poly(ADP-ribose) polymerase-2 (PARP2), members of the PARP superfamily of enzymes, play a key role in DNA damage response (DDR) by acting as DNA damage sensors and signal transducers. In a process known as poly-ADP-ribosylation (PARylation), PARP1 transfers ADP-ribose from nicotinamide adenine dinucleotide (NAD+) to target proteins, which in turn enables recruitment of DNA repair proteins[3]. BGP-15, a hydroxylamine derivative, is a pharmacological coinducer of Hsp72 (heat shock protein 72), shown safe and well tolerated in phase 2 clinical trials for diabetes and insulin resistance[4]. BGP-15 is also a inhibitor of PARP. BGP-15 either blocked or significantly reduced (60-90% in 100-200 mg/kg oral dose) cisplatin induced increase in serum urea and creatinine level in mice and rats and prevented the structural degeneration of the kidney, as well. The nephroprotective effect of BGP-15 treatment was revealed also in living mice by MRI analysis manifesting in the lack of oedema which otherwise developed as a result of cisplatin treatment. BGP-15 decreased cisplatin-induced ROS production in rat kidney mitochondria and improved the antioxidant status of the kidney in mice with cisplatin-induced nephropathy. In rat kidney, cisplatin caused a decrease in the level of Bcl-x, a mitochondrial protective protein, and this was normalized by BGP-15 treatment. Moreover, treatment with BGP-15 increased the mean survival time of cisplatin-treated P-388 leukemia bearing mice from 13 to 19 days[2].
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