There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Mertansine (DM1) serves as a microtubulin inhibitor and is a maytansinoid designed for conjugation to antibodies to form antibody-drug conjugates (ADCs), aimed at reducing systemic toxicity associated with maytansine and improving tumor-specific delivery[1].[2].
体内研究
Despite its efficacy, mertansine has a relatively low maximum-tolerated dose (MTD) of 1 mg/kg[3].
体外研究
Mertansine demonstrates potent antiproliferative effects against over 60 types of cancer cell lines, showcasing broad chemotherapeutic potential[3].
Mertansine exhibits antitumor activity against malignant B16F10 melanoma cells, particularly when combined with DTX, by inhibiting tumor cell growth through the disruption of mitosis[3].
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