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MMAF-Ome甲酯 /MMAF-OMe {[allProObj[0].p_purity_real_show]}

货号:A700623 同义名: Monomethyl auristatin F methyl ester

MMAF-OMe is a synthetic antineoplastic agent and also used as a part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A.

MMAF-OMe 化学结构 CAS号:863971-12-4
MMAF-OMe 化学结构
CAS号:863971-12-4
MMAF-OMe 3D分子结构
CAS号:863971-12-4
MMAF-OMe 化学结构 CAS号:863971-12-4
MMAF-OMe 3D分子结构 CAS号:863971-12-4
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MMAF-OMe 纯度/质量文件 产品仅供科研

货号:A700623 标准纯度: {[allProObj[0].p_purity_real_show]}
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MMAF-OMe 生物活性

描述 MMAF-Ome is a methoxyl analogue of MMAF, used in antibody-drug conjugates (ADCs) as the antimitotic agent part[3]. The methoxyl works as the reaction group. MMAF is a potent auristatin-derived antineoplastic agent, working by inhibition of tubulin polymerization[4]. It exhibited cytotoxicity in Karpas 299, H3396, 786-O and Caki-1 cells with IC50 values of 119nM, 105nM, 257nM and 200nM after 96-hour treatment[3].

MMAF-OMe 动物研究

Dose Rat: 5 mg/kg[3] (i.v.); 10 mg/kg[3] (p.o.) Mice: 16 mg/kg[1] (MTD, i.v.)
Administration i.v., p.o.

MMAF-OMe 参考文献

[1]Doronina SO, Mendelsohn BA, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.

[2]Chen H, Lin Z, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). pii: E1281.

[3]Doronina SO, Mendelsohn BA, Bovee TD, Cerveny CG, Alley SC, Meyer DL, Oflazoglu E, Toki BE, Sanderson RJ, Zabinski RF, Wahl AF, Senter PD. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24. doi: 10.1021/bc0502917. PMID: 16417259.

[4]Chen H, Lin Z, Arnst KE, Miller DD, Li W. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8):1281. doi: 10.3390/molecules22081281. PMID: 28763044; PMCID: PMC6152078.

MMAF-OMe 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.34mL

0.27mL

0.13mL

6.70mL

1.34mL

0.67mL

13.41mL

2.68mL

1.34mL

MMAF-OMe 技术信息

CAS号863971-12-4
分子式C40H67N5O8
分子量 745.989
别名 Monomethyl auristatin F methyl ester
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 105 mg/mL(140.75 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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