货号:A700623 同义名: Monomethyl auristatin F methyl ester
MMAF-OMe is a synthetic antineoplastic agent and also used as a part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A.
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描述 | MMAF-Ome is a methoxyl analogue of MMAF, used in antibody-drug conjugates (ADCs) as the antimitotic agent part[3]. The methoxyl works as the reaction group. MMAF is a potent auristatin-derived antineoplastic agent, working by inhibition of tubulin polymerization[4]. It exhibited cytotoxicity in Karpas 299, H3396, 786-O and Caki-1 cells with IC50 values of 119nM, 105nM, 257nM and 200nM after 96-hour treatment[3]. |
Dose | Rat: 5 mg/kg[3] (i.v.); 10 mg/kg[3] (p.o.) Mice: 16 mg/kg[1] (MTD, i.v.) |
Administration | i.v., p.o. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.34mL 0.27mL 0.13mL |
6.70mL 1.34mL 0.67mL |
13.41mL 2.68mL 1.34mL |
CAS号 | 863971-12-4 |
分子式 | C40H67N5O8 |
分子量 | 745.989 |
别名 | Monomethyl auristatin F methyl ester |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
溶解度 |
DMSO: 105 mg/mL(140.75 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |