MMAF-Ome甲酯 /MMAF-OMe
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货号：A700623
同义名：
Monomethyl auristatin F methyl ester
MMAF-OMe is a synthetic antineoplastic agent and also used as a part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A.
MMAF-OMe 化学结构
MMAF-OMe 3D分子结构
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MMAF-OMe 纯度/质量文件 产品仅供科研
货号：A700623
标准纯度：
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MMAF-OMe 质控信息
MMAF-OMe 生物活性
描述
MMAF-Ome is a methoxyl analogue of MMAF, used in antibody-drug conjugates (ADCs) as the antimitotic agent part[3] [4] [3]
MMAF-OMe 动物研究
Dose
Rat: 5 mg/kg[3] [3] [1]
Administration
i.v., p.o.
MMAF-OMe 参考文献
[1] Doronina SO, Mendelsohn BA, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.
[2] Chen H, Lin Z, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). pii: E1281.
[3] Doronina SO, Mendelsohn BA, Bovee TD, Cerveny CG, Alley SC, Meyer DL, Oflazoglu E, Toki BE, Sanderson RJ, Zabinski RF, Wahl AF, Senter PD. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24. doi: 10.1021/bc0502917. PMID: 16417259.
[4] Chen H, Lin Z, Arnst KE, Miller DD, Li W. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8):1281. doi: 10.3390/molecules22081281. PMID: 28763044; PMCID: PMC6152078.
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MMAF-OMe 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.34mL
0.27mL
0.13mL
6.70mL
1.34mL
0.67mL
13.41mL
2.68mL
1.34mL
MMAF-OMe 技术信息
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