Ro 10-5824 2HCl | Ro 10-5824 dihydrochloride | Dopamine D4 Receptor Partial Agonist

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Ro 10-5824 2HCl {[allProObj[0].p_purity_real_show]}

货号：A747660 同义名： Ro 10-5824 dihydrochloride

Ro 10-5824 2HCl is an agonist of dopamine D4 receptor with Ki of 5.2 nM.

Ro 10-5824 2HCl 化学结构
CAS号：189744-94-3

Ro 10-5824 2HCl 3D分子结构
CAS号：189744-94-3

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Ro 10-5824 2HCl 纯度/质量文件产品仅供科研

货号：A747660 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

多巴胺受体亚型比较

产品名称	D1 receptor ↓ ↑	D2 receptor ↓ ↑	D3 receptor ↓ ↑	D4 receptor ↓ ↑	D5 receptor ↓ ↑	DAT ↓ ↑	Dopamine receptor ↓ ↑	其他靶点	纯度
Penfluridol	+ Dopamine receptor, Ki: 1.6 μM								98%
Ansofaxine HCl	++ Dopamine receptor, IC50: 491 nM								98%
Tetrahydroberberine,THB		+ D2 receptor, pKi: 6.08							98+%
Prochlorperazine Maleate		✔							95%
Olanzapine		✔							99+%
Trifluoperazine		++++ Dopamine D2 receptor, IC50: 1.1 nM							98%
Ropinirole hydrochloride		++ D2 receptor, Ki: 29 nM							99%
Lurasidone		++++ D2 receptor, Ki: 1 nM							98%
Levosulpiride		✔							99+%
Pridopidine		✔							95%
Metoclopramide		✔					✔		99+%
Molindone HCl		✔							98%
Sulpiride		✔							99+%
Perospirone		++++ D2 receptor, Ki: 1.4 nM							99%
Perospirone HCl		++++ D2 receptor, Ki: 1.4 nM							98+%
Phenothiazine		✔							98%
Pimozide	+ Dopamine D1 receptor, Ki: 6600 nM	+++ Dopamine D2 receptor, Ki: 3.0 nM	++++ Dopamine D3 receptor, Ki: 0.83 nM						98%
Rotundine	++ D1 receptor, IC50: 166 nM	+ D2 receptor, IC50: 1.47 μM	+ D3 receptor, IC50: 3.25 μM						98%
Domperidone		✔							99+%
ONC206		✔							97%
Pimethixene maleate	++ Dopamine D1 Receptor, pKi: 6.37	+++ Dopamine D2 Receptor, pKi: 8.19		++ Dopamine D4.4 Receptor, pKi: 7.54					97%
Loxapine succinate	++ D1 receptor (human), Ki: 26 nM D2 receptor (Human), Ki: 62 nM	++ D2 receptor (bovine), Ki: 26 nM D2 receptor (human), Ki: 24 nM		+++ D4 receptor (human), Ki: 7.5 nM					99%
Chlorprothixene	+++ D1 receptor, Ki: 18 nM	+++ D2 receptor, Ki: 2.96 nM	+++ D3 receptor, Ki: 4.56 nM		+++ D5 receptor, Ki: 9 nM				98%
SCH-23390 HCl	++++ D1 dopamine receptor, Ki: 0.2 nM				++++ D5 dopamine receptor, Ki: 0.3 nM				98%
MPP+ iodide						✔			97%
σ1 Receptor antagonist-1						+ DAT, pKi: 5.8			97%
Benztropine mesylate						++ DAT, IC50: 118 nM			98%
Azaperone							✔		98%
Ziprasidone HCl							✔		98+%
Paliperidone							✔		98%
Alizapride HCl							✔		99+%
Amisulpride							✔		98%
Quetiapine hemifumarate							✔	Adrenergic Receptor	98%
Clozapine N-oxide							✔		99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ro 10-5824 2HCl 生物活性

描述

Ro 10-5824 2HCl is a partial agonist of the Dopamine D4 receptor, exhibiting high-affinity binding with a Ki value of 5.2±0.9 nM. It is 250 times more selective for the human D3R receptor and >1000 times more selective for the D4 receptor compared to human D2, D1, and D5 receptors. Ro 10-5824 2HCl stimulates ³⁵S-GTPγS binding with an EC50 value of 205±67 nM, with a maximum induction above baseline of 36±4%^[1].

Ro 10-5824 2HCl 动物研究

Animal study

At a dose of 3 mg/kg, Ro 10-5824 2HCl enhances the success rate of animals in the ORD task. Ro 10-5824 2HCl increases baseline gamma band activity in the frontal cortex at doses of 1 mg/kg and 3 mg/kg. Ro 10-5824 2HCl does not affect the spontaneous movement of animals^[2]. At a dose of 10 mg/kg, Ro 10-5824 2HCl does not increase the number of center entries in a single 60-minute open field session in the absence of new objects, nor does it increase the overall transitions in the initial experiment performed by C57 mice^[1].

Ro 10-5824 2HCl 参考文献

[1]Powell SB, et al. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology. 2003 Mar;44(4):473-81.

[2]Nakazawa S, et al. Behavioral and neurophysiological effects of Ro 10-5824, a dopamine D4 receptor partial agonist, in common marmosets. Psychopharmacology (Berl). 2015 Sep;232(17):3287-95.

Ro 10-5824 2HCl 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.83mL

0.57mL

0.28mL

14.15mL

2.83mL

1.42mL

28.31mL

5.66mL

2.83mL

Ro 10-5824 2HCl 技术信息

CAS号	189744-94-3
分子式	C₁₇H₂₂Cl₂N₄
分子量	353.289

别名	Ro 10-5824 dihydrochloride
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 7 mg/mL(19.81 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 100 mg/mL(283.05 mM)，配合低频超声助溶

动物实验配方

Ro 10-5824 2HCl {[allProObj[0].p_purity_real_show]}

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全球学术期刊中引用的产品

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Ro 10-5824 2HCl 生物活性

Ro 10-5824 2HCl 动物研究

Ro 10-5824 2HCl 参考文献

Ro 10-5824 2HCl 实验方案

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Ro 10-5824 2HCl 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Ro 10-5824 2HCl 质控信息

Ro 10-5824 2HCl 生物活性

Ro 10-5824 2HCl 动物研究

Ro 10-5824 2HCl 参考文献

Ro 10-5824 2HCl 实验方案

Ro 10-5824 2HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Ro 10-5824 2HCl 纯度/质量文件产品仅供科研