FAUC 213
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货号：A1249420
FAUC 213 是一种口服活性高的多巴胺 D4 受体拮抗剂，Ki 值为 2.2 nM，对 D2 和 D3 受体的活性较低。FAUC 213 能够透过血脑屏障，具有非典型抗精神病活性，适用于神经精神疾病的研究。
FAUC 213 化学结构
FAUC 213 3D分子结构
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FAUC 213 纯度/质量文件 产品仅供科研
货号：A1249420
标准纯度：
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产品说明书
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FAUC 213 质控信息
Penfluridol
+
Dopamine receptor, Ki: 1.6 μM
98%
Ansofaxine HCl
++
Dopamine receptor, IC50: 491 nM
98%
Tetrahydroberberine,THB
+
98+%
Prochlorperazine Maleate
✔
95%
Olanzapine
✔
99+%
Trifluoperazine
++++
Dopamine D2 receptor, IC50: 1.1 nM
98%
Ropinirole hydrochloride
++
99%
Lurasidone
++++
98%
Levosulpiride
✔
99+%
Pridopidine
✔
95%
Metoclopramide
✔
✔
99+%
Molindone HCl
✔
98%
Sulpiride
✔
99+%
Perospirone
++++
99%
Perospirone HCl
++++
98+%
Phenothiazine
✔
98%
Pimozide
+
Dopamine D1 receptor, Ki: 6600 nM
+++
Dopamine D2 receptor, Ki: 3.0 nM
++++
Dopamine D3 receptor, Ki: 0.83 nM
98%
Rotundine
++
D1 receptor, IC50: 166 nM
+
D2 receptor, IC50: 1.47 μM
+
D3 receptor, IC50: 3.25 μM
98%
Domperidone
✔
99+%
ONC206
✔
97%
Pimethixene maleate
++
Dopamine D1 Receptor, pKi: 6.37
+++
Dopamine D2 Receptor, pKi: 8.19
++
Dopamine D4.4 Receptor, pKi: 7.54
97%
Loxapine succinate
++
D1 receptor (human), Ki: 26 nM
D2 receptor (Human), Ki: 62 nM
++
D2 receptor (human), Ki: 24 nM
D2 receptor (bovine), Ki: 26 nM
+++
D4 receptor (human), Ki: 7.5 nM
99%
Chlorprothixene
+++
+++
+++
+++
98%
SCH-23390 HCl
++++
D1 dopamine receptor, Ki: 0.2 nM
++++
D5 dopamine receptor, Ki: 0.3 nM
98%
MPP+ iodide
✔
97%
σ1 Receptor antagonist-1
+
97%
Benztropine mesylate
++
98%
Azaperone
✔
98%
Ziprasidone HCl
✔
98+%
Paliperidone
✔
98%
Alizapride HCl
✔
99+%
Amisulpride
✔
98%
Quetiapine hemifumarate
✔
Adrenergic Receptor
98%
Clozapine N-oxide
✔
99%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
FAUC 213 生物活性
描述
FAUC 213 is an orally active, highly selective complete antagonist of the dopamine D4 receptor with a Ki of 2.2 nM for hD4.4, displaying minimal activity on D2 and D3 receptors (Ki of 3.4 μM and 5.3 μM for hD2 and hD3, respectively). FAUC 213 can cross the blood-brain barrier and exhibits characteristics of an atypical antipsychotic[1]
体内研究
FAUC 213, administered orally in single doses ranging from 7.5-30 mg/kg, significantly mitigates AMPH-induced locomotor hyperactivity only with a pre-treatment of 30 mg/kg. It also substantially restores the reduction in prepulse inhibition (PPI) caused by apomorphine treatment at the same dose[1]
体外研究
FAUC 213 shows inhibition of p5-HT1 (Ki=1.2 μM), p5-HT2 (Ki=0.52 μM), and pα1 (Ki=0.27 μM)[1]
FAUC 213 参考文献
FAUC 213 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.06mL
0.61mL
0.31mL
15.30mL
3.06mL
1.53mL
30.60mL
6.12mL
3.06mL
FAUC 213 技术信息
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