16-(S)-ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with good enzyme and antiviral inhibitory activity.

Dieckol 是一种天然存在于一些褐藻物种中的多酚，具有抗菌、抗癌、抗氧化、抗衰老、抗糖尿病和神经保护作用。

16-(R)-ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with good enzyme and antiviral inhibitory activity.

CE-5 blocks MERS-CoV 3CLpro activity with EC50 value of ∼12.5 μM. It inhibited SARS 3CLpro activity with IC50 value of 30nM and exhibited antiviral effect with EC50 value of 6.9μM.

XP-59是一种高效的SARS-CoV Mpro抑制剂，能有效干预病毒的复制过程，对SARS-CoV感染的研究和抗病毒药物开发具有重要意义。

Tanshinone IIA (Tan IIA) 是丹参根的主要成分之一，能够通过靶向 VEGF/VEGFR2 的蛋白激酶结构域来抑制血管生成。

Ensitrelvir是一种口服活性非共价的 SARS-CoV-2 3CL 蛋白酶抑制剂，IC₅₀ 为 13 nM，具有抗 COVID-19 潜力。

Zanamivir is the first of two registered neuraminidase inhibitors for the treatment and prophylaxis of influenza. Zanamivir could inhibit SARS-CoV-2 3CLpro main protease.

Tanshinone IIA sulfonate sodium is a water-soluble derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+entry (SOCE), and is used to treat cardiovascular disorders.

Remdesivir is an nucleotide-analog antiviral prodrug. Remdesivir could inhibit SARS-CoV-2 3CLpro main protease.

Tanshinone I, an active principle isolated from the roots of Salvia miltiorrhiza (Danshen), is an inhibitor of type IIA human recombinant sPLA2 and rabbit recombinant cPLA2 with IC50s of 11 μM and 82 μM, respectively, is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. Tanshinone I showed inhibitory effect on PL(pro) with IC50 value of 8.8μM and less inhibitory effect on 3CLpro with IC50 value of 38.7μM.

Saquinavir mesylate is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir could inhibit SARS-CoV-2 3CLpro main protease.

GC376 is a 3CLpro (3C-like protease) inhibitor that shows promise in treating cats with certain presentations of FIP and has opened the door to targeted antiviral drug therapy.

CCF0058981 is a ML300-derived, non-covalent SARS-CoV‑2 3CLpro inhibitor.

Saquinavir is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir could inhibit SARS-CoV-2 3CLpro main protease.

PF-07321332 is an orally active 3CL protease inhibitor, binding covalently and directly to the catalytic cysteine (Cys145) residue of the enzyme. It works as an anti-SARS-CoV-2 drug.

Aloe-emodin, a natural product isolated and purified from the root of Rheum palmatum L. with a specific in vitro and in vivo anti-neuroectodermal tumor activity, reduces the toxicity and ROS induced by both monomeric and oligomeric Aβ species, appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation and has a strong non-carcinogenic stimulant-laxative action when applied to the skin, although it may increase the carcinogenicity of some kind of radiation. Aloe-Emodine dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 366μM in the cell-based assay.

Cryptotanshinone是一种从丹参根中提取的天然化合物，通过抑制 STAT3 表现出抗肿瘤活性，IC50 为 4.6 μM。

Amentoflavone is an inhibitor of human UDP-glucuronosyltransferases with anti-inflammatory, antioxidative, and neuroprotective effects and it can be isolated from the seeds of Ginkgo biloba L. Amentoflavone inhibited SARS-CoV 3CL(pro) with IC50 value of 8.3μM.

Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram acts as an allosteric inhibitor of MERS-CoV PLpro but as a competitive (or mixed) inhibitor of SARS-CoV PLpro. It also inhibits pyroptosis by blocking gasdermin D pore formation.