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GC376 Sodium Salt {[allProObj[0].p_purity_real_show]}

货号:A723661

GC376 is a 3CLpro (3C-like protease) inhibitor that shows promise in treating cats with certain presentations of FIP and has opened the door to targeted antiviral drug therapy.

GC376 Sodium Salt 化学结构 CAS号:1416992-39-6
GC376 Sodium Salt 化学结构
CAS号:1416992-39-6
GC376 Sodium Salt 3D分子结构
CAS号:1416992-39-6
GC376 Sodium Salt 化学结构 CAS号:1416992-39-6
GC376 Sodium Salt 3D分子结构 CAS号:1416992-39-6
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GC376 Sodium Salt 纯度/质量文件 产品仅供科研

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GC376 Sodium Salt 生物活性

描述 The coronavirus 3C-like protease (3CLpro) has a conserved structure and catalytic mechanism and plays a key role during viral polyprotein processing, thus serving as an appealing antiviral drug target. GC376 exerts strong inhibitory effects on the PEDV (porcine epidemic diarrhea virus) 3CLpro with an IC50 of approximately 1.11 μM. The EC50 values of GC376 against CV777 and YN144 (two PEDV strains) were 11.18 and 14.63 μM, respectively implying that GC376 should efficiently inhibit the replication of different PEDV strains. Compared with the non-drug-treated cells, GC376 reduced virus infection at 1.56 μM. It almost completely inhibited virus replication at approximately 6.25 μM, and cell syncytosis disappeared; 12.5 μM GC376 abolished the infection[1].
作用机制 GC376 inhibits PEDV replication by blocking the catalytic residues and binding pocket of 3CLpro[1].

GC376 Sodium Salt 参考文献

[1]Ye G, Wang X, Tong X, Shi Y, Fu ZF, Peng G. Structural Basis for Inhibiting Porcine Epidemic Diarrhea Virus Replication with the 3C-Like Protease Inhibitor GC376. Viruses. 2020;12(2):240

GC376 Sodium Salt 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.97mL

0.39mL

0.20mL

9.85mL

1.97mL

0.99mL

19.70mL

3.94mL

1.97mL

GC376 Sodium Salt 技术信息

CAS号1416992-39-6
分子式C21H30N3NaO8S
分子量 507.533
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度
动物实验配方
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