Zanamivir is the first of two registered neuraminidase inhibitors for the treatment and prophylaxis of influenza. Zanamivir could inhibit SARS-CoV-2 3CLpro main protease.
Zanamivir is a potent competitive inhibitor of viral neuraminidase, and inhibits a wide range of influenza A and B types in vitro . The drug is selective for the viral form of the neuraminidase enzyme and does not interact to any significant extent with its human lysosomal equivalent[3]. In Madin-Darby canine kidney (MDCK) cell cultures, IC50 values for zanamivir (i.e. the drug concentration required to inhibit plaque formation of influenza A and B viruses by 50%) in laboratory passaged isolates (0.004 to 0.014 μmol/L) and clinical isolates (0.002 to 16 μmol/L) were largely lower than values for amantadine >25 μmol/L), rimantadine (<0.27 to >25 μmol/L) and ribavirin (6.1 to 54 μmol/L)[4]. Zanamivir was also effective in the inhibition of influenza A [A/Virginia/88 (H3N2) and A/Texas/36/91 (H1N1)] and B (B/Hong Kong/5/72) strains in yield reduction assays in human respiratory epithelium, with concentrations required for 90% inhibition of viral replication (IC90) of <0.03 and 0.75 μmol/L, respectively[5]. In MDCK cell cultures,IC50 values for zanamivir ranged from <0.01 to >100 μmol/L and <0.01 to 21 μmol/L against influenza A strains, from 0.03 to 1.3 μmol/L against influenza B strains[6]. Intranasal zanamivir was 100 to 1000 times more active against influenza A [A/Singapore/1/57(H2N2) and A/Mississippi/1/85 (H3N3)] and B(B/Victoria/102/85) than were amantadine and ribavirin in animal studies. In addition, delayed administration of the drug (for up to 22 hours postinfection) reduced viral replication in ferrets[5].
United States, Alabama
... 展开 >>
University of Alabama at Birmingham
Recruiting
Birmingham, Alabama, United States, 35294
Contact: David Kimberlin, M.D. 205-934-5316 dkimberlin@peds.uab.edu
Contact: Dusty Giles, R.N. 205-934-7807 dgiles@peds.uab.edu
Principal Investigator: David Kimberlin, M.D.
United States, Illinois
Northwestern University Feinberg School of Medicine
Recruiting
Chicago, Illinois, United States, 61611
Contact: Mike Ison, M.S., M.D. 312-695-4186 mgison@northwestern.edu
Principal Investigator: Mike Ison, M.S., M.D.
United States, Maryland
University of Maryland School of Medicine
Completed
Baltimore, Maryland, United States, 21201 收起 <<
United States, Washington
... 展开 >>
Seattle Children's
Seattle, Washington, United States, 98105
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98109 收起 <<
Australia, New South Wales
... 展开 >>
St Vincent's Hospital
Sydney, New South Wales, Australia, 2010
Prince of Wales Hospital
Sydney, New South Wales, Australia, 2031
Westmead Hospital
Sydney, New South Wales, Australia, 2145
Australia, Queensland
Royal Brisbane Hospital
Brisbane, Queensland, Australia, 4000
Australia, South Australia
Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000
Flinders Medical Centre
Adelaide, South Australia, Australia, 5042
Australia, Victoria
The Alfred Hospital
Melbourne, Victoria, Australia, 3004
Australia, Western Australia
Royal Perth Hospital
Perth, Western Australia, Australia, 6000 收起 <<
Australia, New South Wales
... 展开 >>
St Vincent's Hospital
Sydney, New South Wales, Australia, 2010
Prince of Wales Hospital
Sydney, New South Wales, Australia, 2031
Westmead Hospital
Sydney, New South Wales, Australia, 2145
Australia, Queensland
Royal Brisbane Hospital
Brisbane, Queensland, Australia, 4000
Australia, South Australia
Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000
Flinders Medical Centre
Adelaide, South Australia, Australia, 5042
Australia, Victoria
The Alfred Hospital
Melbourne, Victoria, Australia, 3004
Australia, Western Australia
Royal Perth Hospital
Perth, Western Australia, Australia, 6000 收起 <<
China, Hong Kong
... 展开 >>
Shau Kei Wan Jockey Club Clinic
Hong Kong, Hong Kong, China, 852
Hong Kong
Fanling Family Medicine Centre
Hong Kong, Hong Kong
Sai Ying Pun Jockey Club General Outpatient Clinic
Hong Kong, Hong Kong 收起 <<
Influenza A Virus Infection
... 展开 >> Influenza B Virus Infection 收起 <<
Phase 3
Completed
-
China
... 展开 >> The Third Xiangya Hospital Of Central South University
Changsha, China
West China Hospital, Sichuan University
Chengdu, China
The First People's Hospital of Hangzhou
Hangzhou, China
The Affiliated Hospital of Inner Mongolia Medical College
Huhehaote, China
The First Affiliated Hospital of Nanchang University
Nanchang, China
The First Affiliated Hospital of Nanjing Medical University
Nanjing, China
Qingdao Municipal Hospital
Qingdao, China
Shanghai 6th People's Hospital
Shanghai, China
Shanghai Changzheng Hospital
Shanghai, China
ShengJing Hospital of China Medical University
Shenyang, China
Tangdu Hospital Affiliated to the Fourth Military Medical University
Xi'an, China
Northern Jiangsu People's Hospital
Yangzhou, China 收起 <<
搜索
