Aloe-emodin, a natural product isolated and purified from the root of Rheum palmatum L. with a specific in vitro and in vivo anti-neuroectodermal tumor activity, reduces the toxicity and ROS induced by both monomeric and oligomeric Aβ species, appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation and has a strong non-carcinogenic stimulant-laxative action when applied to the skin, although it may increase the carcinogenicity of some kind of radiation. Aloe-Emodine dose-dependently inhibited cleavage activity of the 3CLpro with IC50 value of 366μM in the cell-based assay.
Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor properties, capable of binding to and inhibiting the kinase activity of mTORC2, thus exerting antiproliferative effects and inducing apoptosis in cells[1]. It also shows antiviral efficacy against the influenza A virus[2].
体内研究
At doses ranging from 10 to 50 mg/kg, Aloe emodin diminishes tumor growth through the inhibition of mTOR complex2 activity[1].
体外研究
Aloe emodin (0-15 μM; 24-96 h) inhibits PC3 cell proliferation in a dose-dependent manner[1].
Aloe emodin (0-15 μM; 24 h) inhibits the activation of the mTORC2 downstream substrates, Akt, and PKCα, by binding with mTORC2 in cells to suppress its kinase activity.[1].
Aloe emodin 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
A2780 cells
Cytotoxicity assay
Cytotoxicity against human A2780 cells, IC50=26 μM
24326280
HCT116 cells
Cytotoxicity assay
24 h
Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay, IC50=8.7 μM
17949858
HepG2 cells
Cytotoxicity assay
24 h
Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay, IC50=10 μM
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