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丹参酮IIA /Tanshinone IIA {[allProObj[0].p_purity_real_show]}

货号:A104838 同义名: Dan Shen ketone;NSC 686518 Ambeed 开学季,买赠积分,赢豪礼

Tanshinone IIA (Tan IIA) 是丹参根的主要成分之一,能够通过靶向 VEGF/VEGFR2蛋白激酶结构域来抑制血管生成。

Tanshinone IIA 化学结构 CAS号:568-72-9
Tanshinone IIA 化学结构
CAS号:568-72-9
Tanshinone IIA 3D分子结构
CAS号:568-72-9
Tanshinone IIA 化学结构 CAS号:568-72-9
Tanshinone IIA 3D分子结构 CAS号:568-72-9
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Tanshinone IIA 纯度/质量文件 产品仅供科研

货号:A104838 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 NF-κB 其他靶点 纯度
Pyrrolidinedithiocarbamate ammonium {[allProObj[0].p_purity_real_show]}
QNZ ++++

NF-κB, IC50: 11 nM

{[allProObj[0].p_purity_real_show]}
Sodium 4-Aminosalicylate Dihydrate {[allProObj[0].p_purity_real_show]}
Sodium Salicylate {[allProObj[0].p_purity_real_show]}
Parthenolide p53 {[allProObj[0].p_purity_real_show]}
JSH-23 +

NF-κB, IC50: 7.1 μM

{[allProObj[0].p_purity_real_show]}
Phenethyl caffeate {[allProObj[0].p_purity_real_show]}
Andrographolide {[allProObj[0].p_purity_real_show]}
Curcumin HDAC,Nrf2 {[allProObj[0].p_purity_real_show]}
SC75741 +++

NF-κB, EC50: 200 nM

{[allProObj[0].p_purity_real_show]}
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

p53 {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Tanshinone IIA 生物活性

靶点
  • Lipase

描述 Sodium tanshinone IIA sulfonate (STS) is one of the derivatives of tanshinone IIA (Tan IIA) which is a main lipophilic constitute of Chinese Materia Medica Salvia miltiorrhiza Bge. (Danshen)[3].Tan-IIA reduces the production of inflammatory mediators and restores abnormal signaling pathways via regulating the function and activation of immune cells. It can also regulate signal transduction pathways, ie, TLR/NF-κB pathway and MAPKs/NF-κB pathway, thereby tan-IIA has an anti-inflammatory, anticoagulant, antithrombotic and neuroprotective role[4]. In vivo , echocardiography results showed that Tanshinone IIA could significantly improve heart function. Western Blot result showed that Tanshinone IIA treatment enhanced autophagy and regulated expressions of key autophagy-related molecules, including protein 1 light chain 3 (LC3), p62 and Beclin1. Tanshinone IIA also inhibited apoptosis and regulated expressions of key apoptotic protein, including B cell lymphoma-2 (Bcl-2) and Bcl-2 Associated X Protein (Bax) and cleaved caspase-3 and -7. Further experiments demonstrated that the effects of Tanshinone IIA were mediated through upregulation of AMPK and downregulation of mTOR simultaneously. The mTOR agonist MHY1485 could abrogate the therapeutic effect of Tanshinone IIA in vitro [5]. Tanshinone IIA has anti-adipogenic effects on 3T3-L1 cells and zebrafish, and its anti-adipogenic effect on 3T3-L1 cells is largely attributable to the reduced expression and/or phosphorylation levels of C/EBP-α, PPAR-γ, FAS, perilipin A, and STAT-3/5[6].Tan IIA treatment of high-fat diet fed ApoE-/- mice significantly attenuated NLRP3 inflammasome activation In vivo . Consistently, Tan IIA also potently inhibited oxLDL-induced NLRP3 inflammasome activation in mouse macrophages[7].

Tanshinone IIA 参考文献

[1]Fu J, Huang H, et al. Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis. Eur J Pharmacol. 2007 Jul 30;568(1-3):213-21.

[2]Wang X, Wei Y, et al. Potential anticancer activity of tanshinone IIA against human breast cancer. Int J Cancer. 2005 Sep 20;116(5):799-807.

[3]Zhong-Yan Zhou,et al. Sodium tanshinone IIA sulfonate: A review of pharmacological activity and pharmacokinetics, Biomed Pharmacother. 2019 Oct;118:109362.

[4]Rui Guo,et al. Drug Des Devel Ther. 2020 Nov 5;14:4735-4748.

[5]Xuefeng Zhang,et al. Tanshinone IIA protects against heart failure post-myocardial infarction via AMPKs/mTOR-dependent autophagy pathway. Biomed Pharmacother. 2019 Apr;112:108599.

[6]Yu-Kyoung Park,et al. Anti-Adipogenic Effects on 3T3-L1 Cells and Zebrafish by Tanshinone IIA. Int J Mol Sci. 2017 Sep 27;18(10):2065.

[7]Jiexia Wen,et al. Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation. Aging (Albany NY). 2020 Nov 16;13(1):910-932.

Tanshinone IIA 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.40mL

0.68mL

0.34mL

16.99mL

3.40mL

1.70mL

33.97mL

6.79mL

3.40mL

Tanshinone IIA 技术信息

CAS号568-72-9
分子式C19H18O3
分子量 294.344
别名 Dan Shen ketone;NSC 686518;TSA;NSC 686519;Tanshinone B
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 1 mg/mL(3.4 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方

5% DMSO+30% PEG 300+2% Tween 80+water 0.2 mg/mL

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