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/ Tanshinone I

丹参酮I /Tanshinone I {[allProObj[0].p_purity_real_show]}

货号：A108483 同义名： Tanshinone A

Tanshinone I, an active principle isolated from the roots of Salvia miltiorrhiza (Danshen), is an inhibitor of type IIA human recombinant sPLA2 and rabbit recombinant cPLA2 with IC50s of 11 μM and 82 μM, respectively, is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. Tanshinone I showed inhibitory effect on PL(pro) with IC50 value of 8.8μM and less inhibitory effect on 3CLpro with IC50 value of 38.7μM.

Tanshinone I 化学结构 CAS号：568-73-0
Tanshinone I 化学结构
CAS号：568-73-0
Tanshinone I 3D分子结构
CAS号：568-73-0
Tanshinone I 化学结构 CAS号：568-73-0
Tanshinone I 3D分子结构 CAS号：568-73-0
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Tanshinone I 纯度/质量文件 产品仅供科研

货号：A108483 标准纯度： {[allProObj[0].p_purity_real_show]}
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Tanshinone I 生物活性

描述 Tanshinone I, a major active principle of Salvia miltiorrhiza with anti-tumor and anti-metastasis effcts. In vitro, Tanshinone-1 had an IC50 value of 7.75 μM in HMEC-1 cells for the 72-h treatment. Tanshinone-1 displayed only marginal proliferation inhibition on HMEC-1 cells even at 50 μM. In endothelial cells, tanshinone-1 almost completely inhibited phosphorylation of Stat3 at Tyr705 [3]. In vivo, Tanshinone I could inhibit apoptosis and inflammation in IL-1β-stimulated CHON-001 cells. Moreover, Tanshinone I treatment markedly decreased the subchondral bone thickness and synovitis scores[4].

Tanshinone I 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02524964 Left Ventricular Remodeling ... 展开 >> Acute Myocardial Infarction 收起 << Phase 4 Unknown July 2017 China, Guangdong ... 展开 >> Guangdong Provincial Hospital of Chinese Medicine Recruiting Guangzhou, Guangdong, China, 510120 Contact: Minzhou Zhang, Dr.    86-20-81887233 ext 32801    minzhouzhang@yeah.net    Contact: Liheng Guo, Dr.    86-8187236 ext 32907    lihengguo1@yeah.net 收起 <<
NCT01452477 Polycystic Ovary Syndrome Not Applicable Unknown July 2014 China, Heilongjiang ... 展开 >> Heilongjiang University of Chinese Medicine Recruiting Harbin, Heilongjiang, China, 150040 Contact: Wenjuan Shen, doctor    +86-045182118464    shenwenjuankx@163.com    Contact: Yuehui Zhang, doctor    +86-045182118464    manbingPCOS@163.com    Principal Investigator: Wenjuan Shen, doctor          China, Jiangsu Huaian Maternal and Child Health Hospital Recruiting Huaian, Jiangsu, China, 223001 Contact: Huiying Xue, Scholar    +8613505238015    haxuehuiying@126.com    Principal Investigator: Huiying Xue, bachlor          Lianyungang Maternal and Child Health Hospital Active, not recruiting Lianyungang, Jiangsu, China, 222000 China, Jiangxi JiangXi University of Traditional Chinese Medicine Completed Nanchang, Jiangxi, China, 330000 收起 <<
NCT01637675 Pulmonary Hypertension ... 展开 >> Pulmonary Arterial Hypertension Cardiovascular Diseases Lung Diseases Tanshinone IIA Sulfonate 收起 << Phase 2 Phase 3 Unknown December 2014 China, Guangdong ... 展开 >> The First Affiliated Hospital of Guangzhou Medical University Recruiting Guangzhou, Guangdong, China, 510120 Contact: Jian Wang, MD    +8615013388183    jwang31@jhmi.edu 收起 <<

Tanshinone I 参考文献

[1]Nizamutdinova IT, Lee GW, et al. Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules. Carcinogenesis. 2008 Oct;29(10):1885-92.

[2]Kim SY, Moon TC, et al. Effects of tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses. Phytother Res. 2002 Nov;16(7):616-20.

[3]Wang Y, Li JX, Wang YQ, Miao ZH. Tanshinone I inhibits tumor angiogenesis by reducing Stat3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells. Oncotarget. 2015 Jun 30;6(18):16031-42. doi: 10.18632/oncotarget.3648. PMID: 26202747; PMCID: PMC4599254.

[4]Wang X, Fan J, Ding X, Sun Y, Cui Z, Liu W. Tanshinone I Inhibits IL-1β-Induced Apoptosis, Inflammation And Extracellular Matrix Degradation In Chondrocytes CHON-001 Cells And Attenuates Murine Osteoarthritis. Drug Des Devel Ther. 2019 Oct 15;13:3559-3568. doi: 10.2147/DDDT.S216596. PMID: 31686786; PMCID: PMC6800556.

[5]Kim DH, Kim S, Jeon SJ, et al. Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal-regulated kinase signalling pathway. Br J Pharmacol. 2009;158(4):1131-1142.

Tanshinone I 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.62mL

0.72mL

0.36mL

18.10mL

3.62mL

1.81mL

36.19mL

7.24mL

3.62mL

Tanshinone I 技术信息

CAS号568-73-0
分子式C18H12O3
分子量 276.286
别名 Tanshinone A
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,2-8°C
溶解度

DMSO: 2 mg/mL(7.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Tanshinone I | Tanshinone A | Plant Standard | 3CLpro | PLP | AmBeed-信号通路专用抑制剂 | Tanshinone I 纯度/质量文件 | Tanshinone I 生物活性 | Tanshinone I 临床数据 | Tanshinone I 参考文献 | Tanshinone I 实验方案 | Tanshinone I 技术信息

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