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丹参酮I /Tanshinone I {[allProObj[0].p_purity_real_show]}

货号：A108483 同义名： Tanshinone A

Tanshinone I是从Salvia miltiorrhiza（丹参）根部提取的活性成分，抑制IIA型人重组sPLA2和兔重组cPLA2，IC50分别为11 μM和82 μM，结构上类似于Tanshinone IIA，可能对肿瘤细胞具有类似的细胞毒性作用。Tanshinone I对PL(pro)的抑制效果为IC50值8.8μM，对3CLpro的抑制效果较弱，IC50为38.7μM。

Tanshinone I 化学结构
CAS号：568-73-0

Tanshinone I 3D分子结构
CAS号：568-73-0

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Tanshinone I 纯度/质量文件产品仅供科研

货号：A108483 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]; • Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]; • Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]; 更多 >

Tanshinone I 生物活性

描述

Tanshinone I, a major active principle of Salvia miltiorrhiza with anti-tumor and anti-metastasis effcts. In vitro, Tanshinone-1 had an IC₅₀ value of 7.75 μM in HMEC-1 cells for the 72-h treatment. Tanshinone-1 displayed only marginal proliferation inhibition on HMEC-1 cells even at 50 μM. In endothelial cells, tanshinone-1 almost completely inhibited phosphorylation of Stat3 at Tyr705 ^[3]. In vivo, Tanshinone I could inhibit apoptosis and inflammation in IL-1β-stimulated CHON-001 cells. Moreover, Tanshinone I treatment markedly decreased the subchondral bone thickness and synovitis scores^[4].

Tanshinone I 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02524964	Left Ventricular Remodeling ... 展开 >> Acute Myocardial Infarction 收起 <<	Phase 4	Unknown	July 2017	China, Guangdong ... 展开 >> Guangdong Provincial Hospital of Chinese Medicine Recruiting Guangzhou, Guangdong, China, 510120 Contact: Minzhou Zhang, Dr. 86-20-81887233 ext 32801 minzhouzhang@yeah.net Contact: Liheng Guo, Dr. 86-8187236 ext 32907 lihengguo1@yeah.net 收起 <<
NCT01452477	Polycystic Ovary Syndrome	Not Applicable	Unknown	July 2014	China, Heilongjiang ... 展开 >> Heilongjiang University of Chinese Medicine Recruiting Harbin, Heilongjiang, China, 150040 Contact: Wenjuan Shen, doctor +86-045182118464 shenwenjuankx@163.com Contact: Yuehui Zhang, doctor +86-045182118464 manbingPCOS@163.com Principal Investigator: Wenjuan Shen, doctor China, Jiangsu Huaian Maternal and Child Health Hospital Recruiting Huaian, Jiangsu, China, 223001 Contact: Huiying Xue, Scholar +8613505238015 haxuehuiying@126.com Principal Investigator: Huiying Xue, bachlor Lianyungang Maternal and Child Health Hospital Active, not recruiting Lianyungang, Jiangsu, China, 222000 China, Jiangxi JiangXi University of Traditional Chinese Medicine Completed Nanchang, Jiangxi, China, 330000 收起 <<
NCT01637675	Pulmonary Hypertension ... 展开 >> Pulmonary Arterial Hypertension Cardiovascular Diseases Lung Diseases Tanshinone IIA Sulfonate 收起 <<	Phase 2 Phase 3	Unknown	December 2014	China, Guangdong ... 展开 >> The First Affiliated Hospital of Guangzhou Medical University Recruiting Guangzhou, Guangdong, China, 510120 Contact: Jian Wang, MD +8615013388183 jwang31@jhmi.edu 收起 <<

Tanshinone I 参考文献

[1]Nizamutdinova IT, Lee GW, et al. Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules. Carcinogenesis. 2008 Oct;29(10):1885-92.

[2]Kim SY, Moon TC, et al. Effects of tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses. Phytother Res. 2002 Nov;16(7):616-20.

[3]Wang Y, Li JX, Wang YQ, Miao ZH. Tanshinone I inhibits tumor angiogenesis by reducing Stat3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells. Oncotarget. 2015 Jun 30;6(18):16031-42. doi: 10.18632/oncotarget.3648. PMID: 26202747; PMCID: PMC4599254.

[4]Wang X, Fan J, Ding X, Sun Y, Cui Z, Liu W. Tanshinone I Inhibits IL-1β-Induced Apoptosis, Inflammation And Extracellular Matrix Degradation In Chondrocytes CHON-001 Cells And Attenuates Murine Osteoarthritis. Drug Des Devel Ther. 2019 Oct 15;13:3559-3568. doi: 10.2147/DDDT.S216596. PMID: 31686786; PMCID: PMC6800556.

[5]Kim DH, Kim S, Jeon SJ, et al. Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal-regulated kinase signalling pathway. Br J Pharmacol. 2009;158(4):1131-1142.

Tanshinone I 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.62mL

0.72mL

0.36mL

18.10mL

3.62mL

1.81mL

36.19mL

7.24mL

3.62mL

Tanshinone I 技术信息

CAS号	568-73-0
分子式	C₁₈H₁₂O₃
分子量	276.286

别名	Tanshinone A
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Sealed in dry,2-8°C

溶解度

DMSO: 2 mg/mL(7.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02524964	Left Ventricular Remodeling ... 展开 >> Acute Myocardial Infarction 收起 <<	Phase 4	Unknown	July 2017	China, Guangdong ... 展开 >> Guangdong Provincial Hospital of Chinese Medicine Recruiting Guangzhou, Guangdong, China, 510120 Contact: Minzhou Zhang, Dr. 86-20-81887233 ext 32801 minzhouzhang@yeah.net Contact: Liheng Guo, Dr. 86-8187236 ext 32907 lihengguo1@yeah.net 收起 <<
NCT01452477	Polycystic Ovary Syndrome	Not Applicable	Unknown	July 2014	China, Heilongjiang ... 展开 >> Heilongjiang University of Chinese Medicine Recruiting Harbin, Heilongjiang, China, 150040 Contact: Wenjuan Shen, doctor +86-045182118464 shenwenjuankx@163.com Contact: Yuehui Zhang, doctor +86-045182118464 manbingPCOS@163.com Principal Investigator: Wenjuan Shen, doctor China, Jiangsu Huaian Maternal and Child Health Hospital Recruiting Huaian, Jiangsu, China, 223001 Contact: Huiying Xue, Scholar +8613505238015 haxuehuiying@126.com Principal Investigator: Huiying Xue, bachlor Lianyungang Maternal and Child Health Hospital Active, not recruiting Lianyungang, Jiangsu, China, 222000 China, Jiangxi JiangXi University of Traditional Chinese Medicine Completed Nanchang, Jiangxi, China, 330000 收起 <<
NCT01637675	Pulmonary Hypertension ... 展开 >> Pulmonary Arterial Hypertension Cardiovascular Diseases Lung Diseases Tanshinone IIA Sulfonate 收起 <<	Phase 2 Phase 3	Unknown	December 2014	China, Guangdong ... 展开 >> The First Affiliated Hospital of Guangzhou Medical University Recruiting Guangzhou, Guangdong, China, 510120 Contact: Jian Wang, MD +8615013388183 jwang31@jhmi.edu 收起 <<
NCT02200978	Childhood Acute Promyelocytic ... 展开 >>Leukemia 收起 <<	Phase 4	Recruiting	September 2022	China, Guangdong ... 展开 >> The First Affiliated Hospital of Sun Yat-Sen University Recruiting Guangzhou, Guangdong, China, 510080 Contact: Xue-Qun Luo, professor L-xuequn@126.com Principal Investigator: Xue-Qun Luo, professor 收起 <<

丹参酮I /Tanshinone I {[allProObj[0].p_purity_real_show]}

Tanshinone I 纯度/质量文件产品仅供科研

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丹参酮I /Tanshinone I {[allProObj[0].p_purity_real_show]}

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全球学术期刊中引用的产品

Tanshinone I 质控信息

Tanshinone I 生物活性

Tanshinone I 临床研究

Tanshinone I 参考文献

Tanshinone I 实验方案

Tanshinone I 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Tanshinone I 纯度/质量文件产品仅供科研