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穗花杉双黄酮 /Amentoflavone {[allProObj[0].p_purity_real_show]}

货号:A421989 同义名: Didemethyl-ginkgetin;NSC 295677

Amentoflavone is an inhibitor of human UDP-glucuronosyltransferases with anti-inflammatory, antioxidative, and neuroprotective effects and it can be isolated from the seeds of Ginkgo biloba L. Amentoflavone inhibited SARS-CoV 3CL(pro) with IC50 value of 8.3μM.

Amentoflavone 化学结构 CAS号:1617-53-4
Amentoflavone 化学结构
CAS号:1617-53-4
Amentoflavone 3D分子结构
CAS号:1617-53-4
Amentoflavone 化学结构 CAS号:1617-53-4
Amentoflavone 3D分子结构 CAS号:1617-53-4
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Amentoflavone 纯度/质量文件 产品仅供科研

货号:A421989 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Transferase 其他靶点 纯度
Tipifarnib +++

FTase, IC50: 0.6 nM

99%+
Tolcapone +

COMT, Ki: 30 nM

99%+
Lonafarnib +++

K-ras-4B, IC50: 2.8 nM

H-ras, IC50: 1.9 nM

99%+
(E)-Daporinad ++++

NMPRTase, Ki: 0.4 nM

99%+
FTI-277 HCl ++++

FTase, IC50: 500 pM

98%
A 922500 ++

human DGAT-1, IC50: 7 nM

mouse DGAT-1, IC50: 24 nM

98%
Lomeguatrib ++

O6-alkylguanine-DNA-alkyltransferas, IC50: 5 nM

99%+
PF-04620110 +

DGAT1, IC50: 19 nM

98%
LB42708 +++

FTase (K-Ras), IC50: 0.8 nM

FTase (N-ras), IC50: 1.2 nM

98%
GGTI298 Trifluoroacetate 98%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Amentoflavone 生物活性

描述 Amentoflavone is the main component of Selaginella tamariscina widely known as an oriental traditional medicinal stuff that has been known to have a variety of medicinal effects such as the induction of apoptosis, antimetastasis, and anti-inflammation. Amentoflavone could play a positive role in the inhibition of various diseases associated with autophagy and the modulation of p53[3]. Amentoflavone affects epileptogenesis and exerts neuroprotective effects by inhibiting the NLRP3 inflammasome and, thus, mediating the inflammatory process in PTZ(pentylenetetrazole)-induced kindling mice and LPS(lipopolysaccharide)-induced BV2 microglial cells[4]. In vivo, the tumor growth was suppressed by AF (Amentoflavone) in a dose-dependent manner. The level of MDA (malondialdehyde) in the tumor tissue was increased while the level of GSH (reduced glutathione) in tumor tissue was decreased by AF in a dose-dependent manner. Furthermore, the expression of LC3B, Beclin1, ATG5, ATG7 were increased, and the expression of FTH (ferritin heavy chain) were decreased by AF in a dose-dependent manner in vivo[5]. Amentoflavone inhibits HCC (hepatocellular carcinoma) progression through suppression of ERK(extracellular signal-regulated kinase )/NF-ĸB (nuclear factor-kappaB) signaling[6]. In addition, amentoflavone improves the osteogenesis of hMSCs (human mesenchymal stem cells) through the JNK and p38 MAPK pathway[7].

Amentoflavone 参考文献

[1]Lv X, Zhang JB, et al. Amentoflavone is a potent broad-spectrum inhibitor of human UDP-glucuronosyltransferases. Chem Biol Interact. 2018.

[2]Sakthivel KM, Guruvayoorappan C. Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-κB signal transduction pathways in rats with ulcerative colitis. Int Immunopharmacol. 2013 Nov;17(3):907-16.

[3]Park HJ, Kim MM. Amentoflavone Induces Autophagy and Modulates p53. Cell J. 2019 Apr;21(1):27-34

[4]Rong S, Wan D, Fan Y, Liu S, Sun K, Huo J, Zhang P, Li X, Xie X, Wang F, Sun T. Amentoflavone Affects Epileptogenesis and Exerts Neuroprotective Effects by Inhibiting NLRP3 Inflammasome. Front Pharmacol. 2019 Jul 30;10:856

[5]Chen Y, Li N, Wang H, Wang N, Peng H, Wang J, Li Y, Liu M, Li H, Zhang Y, Wang Z. Amentoflavone suppresses cell proliferation and induces cell death through triggering autophagy-dependent ferroptosis in human glioma. Life Sci. 2020 Apr 15;247:117425

[6]Lee KC, Chen WT, Liu YC, Lin SS, Hsu FT. Amentoflavone Inhibits Hepatocellular Carcinoma Progression Through Blockage of ERK/NF-ĸB Activation. In Vivo. 2018 Sep-Oct;32(5):1097-1103

[7]Zha X, Xu Z, Liu Y, Xu L, Huang H, Zhang J, Cui L, Zhou C, Xu D. Amentoflavone enhances osteogenesis of human mesenchymal stem cells through JNK and p38 MAPK pathways. J Nat Med. 2016 Jul;70(3):634-44

Amentoflavone 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.29mL

1.86mL

0.93mL

18.57mL

3.71mL

1.86mL

Amentoflavone 技术信息

CAS号1617-53-4
分子式C30H18O10
分子量 538.458
别名 Didemethyl-ginkgetin;NSC 295677;38Biapigenin
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C

溶解度

DMSO: 120 mg/mL(222.86 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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