Tasisulam, an anticancer agent, induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. It also inhibits mitotic progression and induces vascular normalization [1].
体外研究
Tasisulam (200 nM-200 μM; 48 hours) elicits an antiproliferative response across various tumor histologies, with EC50s of 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively [1].
Tasisulam (25, 50 μM; 72 hours) induces concentration-dependent increases in 4N DNA and G2-M accumulation [1].
Tasisulam induces apoptosis in diverse in vitro cancer cell models within the concentration range of 200 nM to 200 μM over 48 hours [1].
Tasisulam also inhibits VEGF, epidermal growth factor, and fibroblast growth factor-induced endothelial cell cord formation [1].
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