Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
细胞生物学 药物研究 抗生素和抗病毒 囊泡 肿瘤
/
细胞凋亡
小分子阳性药 其他抑制剂/激动剂 功能 结构 NF-κB 帕金森与阿尔茨海默症 肿瘤干细胞 PPARs Wnt 细胞焦亡
/
抗病毒
NF-κB 磺胺类 铁死亡抑制剂 抗炎
/ Sulfasalazine

柳氮磺吡啶 /Sulfasalazine {[allProObj[0].p_purity_real_show]}

货号：A176325 同义名： 柳氮磺胺吡啶 / NSC 667219;Azopyrin

Sulfasalazine(NSC 667219) 是一种抗风湿剂，用于类风湿性关节炎和溃疡性结肠炎的研究。它抑制 NF-κB 活性并作为 I 型铁死亡诱导剂。

Sulfasalazine 化学结构 CAS号：599-79-1
Sulfasalazine 化学结构
CAS号：599-79-1
Sulfasalazine 3D分子结构
CAS号：599-79-1
Sulfasalazine 化学结构 CAS号：599-79-1
Sulfasalazine 3D分子结构 CAS号：599-79-1
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

Sulfasalazine 纯度/质量文件 产品仅供科研

货号：A176325 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Cell, 2024, 101755. Ambeed. [ A399663 ]
• EMBO J., 2024. Ambeed. [ A295334 ]
• JMC, 2024, 67(20): 18265-18289. Ambeed. [ A538667 , A341145 , A117430 , A172297 ]
• JMC, 2024. Ambeed. [ A210558 , A1518164 ]
• Cell Death Discov., 2024, 10, 436. Ambeed. [ A384235 ]
更多 >
产品名称 NF-κB ↓ 其他靶点 纯度
PDTC ammonium ✔ 98%
QNZ ++++

NF-κB, IC50: 11 nM

 		99%+
Sodium 4-Aminosalicylate Dihydrate ✔ 98%
Sodium Salicylate ✔ 95%
Parthenolide ✔ p53 97% HPLC
JSH-23 +

NF-κB, IC50: 7.1 μM

 		98%
Phenethyl caffeate ✔ 98%
Andrographolide ✔ 98+%
Curcumin ✔ Nrf2,HDAC 98%
SC75741 +++

NF-κB, EC50: 200 nM

 		99%+
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

 		p53 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Sulfasalazine 生物活性

描述 Sulfasalazine is a potent and specific inhibitor of NF-kappaB activation. Treatment of SW620 colon cells with sulfasalazine inhibited TNFalpha-, LPS-, or phorbol ester- induced NF-kappaB activation. NF-kappaB-dependent transcription was inhibited by sulfasalazine at micro- to millimolar concentrations. TNFalpha-induced nuclear translocation of NF-kappaB was prevented by sulfasalazine through inhibition of IkappaBalpha degradation[3]. Sulfasalazine is a direct inhibitor of IKK-alpha and -beta by antagonizing adenosine triphosphate binding. The suppression of NF-kappaB activation by inhibition of the IKKs contributes to the well-known anti-inflammatory and immunosuppressive effects of sulfasalazine[4]. Sulfasalazine can inhibit NF-κB and reduce lipopolysaccharide-induced cytokine concentrations in fetal membrane explants and reduce the rate of Escherichia coli-induced preterm labour in mice[5]. Sulfasalazine induces cell death via apoptosis in HBx-expressing liver cells, as evidenced by characteristic changes in nuclear morphology, cleavage of poly (ADP-ribose) polymerase (PARP), caspase-3 and caspase-9, and activation of caspase-3[6].

Sulfasalazine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02930343 Rheumatoid Arthritis Phase 4 Recruiting August 2018 India ... 展开 >> Department of Clinical Immunology , Jawaharlal Institute of Post graduate Medical Educationa and Research Recruiting Pondicherry, India, 605006 Contact: Dr. Vir Singh Negi, DM    0413-2297358    vsnegi22@yahoo.co.in    Contact: Dr. Pooja Belani, MD    8940482248    drpoojabelani@gmail.com 收起 <<
NCT02590562 - Completed - China ... 展开 >> Peking University First Hospital Beijing, China, 100034 Beijing Jishutan Hospital; Rheumatology & Immunology Beijing, China, 100035 Peking University People's Hospital Beijing, China, 100044 Peking University Third Hospital Beijing, China, 100083 China-Janpan Friendship Hospital of Jilin University Changchun, China, 130031 West China Hospital, Sichuan University Chengdu, China, 610041 Sichuan Provincial People's Hospital Chengdu, China, 610072 The First Affiliated Hospital, Sun Yat-sen University Guangzhou, China, 510080 The First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou, China, 510405 Nanfang Hospital, Southern Medical University Guangzhou, China, 510515 Guanghua Hospital of Integrated Traditional Chinese and Western Medicine ( Guanghua Hospital) Shanghai, China, 200052 The Second Hospital of Shanxi Medical University Taiyuan, China, 030001 Tianjin Medical University General Hospital Tianjin (天津), China, 300052 First Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an, China, 710061 Xinjiang Uygur Autonomous Region People Hospital Ürümqi, China, 830001 收起 <<
NCT02590562 - Completed - -

Sulfasalazine 参考文献

[1]Liptay S, Bachem M, et al. Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine. Br J Pharmacol. 1999 Dec;128(7):1361-9.

[2]Gadangi P, Longaker M, et al. The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites. J Immunol. 1996 Mar 1;156(5):1937-41.

[3]Wahl C, Liptay S, Adler G, Schmid RM. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J Clin Invest. 1998 Mar 1;101(5):1163-74

[4]Weber CK, Liptay S, Wirth T, Adler G, Schmid RM. Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta. Gastroenterology. 2000 Nov;119(5):1209-18

[5]Sykes L, Thomson KR, Boyce EJ, Lee YS, Rasheed ZB, MacIntyre DA, Teoh TG, Bennett PR. Sulfasalazine augments a pro-inflammatory response in interleukin-1β-stimulated amniocytes and myocytes. Immunology. 2015 Dec;146(4):630-44

[6]Lee YM, Kang M, Hwang JM, Lee S, Cho H, Kim YS. Sulfasalazine induces apoptosis of HBx-expressing cells in an NF-kappaB-independent manner. Virus Genes. 2010 Feb;40(1):37-43

Sulfasalazine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.51mL

0.50mL

0.25mL

12.55mL

2.51mL

1.26mL

25.10mL

5.02mL

2.51mL

Sulfasalazine 技术信息

CAS号599-79-1
分子式C18H14N4O5S
分子量 398.39
别名 柳氮磺胺吡啶 ;NSC 667219;Azopyrin;Rorasul;Reupirin;NSC-203730 NSC 203730;NSC 203730;Sulphasalazine
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Room Temperature
溶解度

DMSO: 85 mg/mL(213.36 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

NH4OH: 150 mg/mL(376.52 mM)，配合低频超声，并调节pH至9
动物实验配方

Tags: Sulfasalazine | 599-79-1 | NSC 667219 | NSC667219 | NSC-667219 | NF-κB | Autophagy | Apoptosis | Anti-infection | NF-κB | Autophagy | Apoptosis | Ferroptosis | Bacterial | Antibiotic | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Sulfasalazine 纯度/质量文件 | Sulfasalazine 亚型比较 | Sulfasalazine 生物活性 | Sulfasalazine 临床数据 | Sulfasalazine 参考文献 | Sulfasalazine 实验方案 | Sulfasalazine 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z