Sulfasalazine is a potent and specific inhibitor of NF-kappaB activation. Treatment of SW620 colon cells with sulfasalazine inhibited TNFalpha-, LPS-, or phorbol ester- induced NF-kappaB activation. NF-kappaB-dependent transcription was inhibited by sulfasalazine at micro- to millimolar concentrations. TNFalpha-induced nuclear translocation of NF-kappaB was prevented by sulfasalazine through inhibition of IkappaBalpha degradation[3]. Sulfasalazine is a direct inhibitor of IKK-alpha and -beta by antagonizing adenosine triphosphate binding. The suppression of NF-kappaB activation by inhibition of the IKKs contributes to the well-known anti-inflammatory and immunosuppressive effects of sulfasalazine[4]. Sulfasalazine can inhibit NF-κB and reduce lipopolysaccharide-induced cytokine concentrations in fetal membrane explants and reduce the rate of Escherichia coli-induced preterm labour in mice[5]. Sulfasalazine induces cell death via apoptosis in HBx-expressing liver cells, as evidenced by characteristic changes in nuclear morphology, cleavage of poly (ADP-ribose) polymerase (PARP), caspase-3 and caspase-9, and activation of caspase-3[6].
India
... 展开 >> Department of Clinical Immunology , Jawaharlal Institute of Post graduate Medical Educationa and Research
Recruiting
Pondicherry, India, 605006
Contact: Dr. Vir Singh Negi, DM 0413-2297358 vsnegi22@yahoo.co.in
Contact: Dr. Pooja Belani, MD 8940482248 drpoojabelani@gmail.com 收起 <<
China
... 展开 >> Peking University First Hospital
Beijing, China, 100034
Beijing Jishutan Hospital; Rheumatology & Immunology
Beijing, China, 100035
Peking University People's Hospital
Beijing, China, 100044
Peking University Third Hospital
Beijing, China, 100083
China-Janpan Friendship Hospital of Jilin University
Changchun, China, 130031
West China Hospital, Sichuan University
Chengdu, China, 610041
Sichuan Provincial People's Hospital
Chengdu, China, 610072
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, China, 510080
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, China, 510405
Nanfang Hospital, Southern Medical University
Guangzhou, China, 510515
Guanghua Hospital of Integrated Traditional Chinese and Western Medicine ( Guanghua Hospital)
Shanghai, China, 200052
The Second Hospital of Shanxi Medical University
Taiyuan, China, 030001
Tianjin Medical University General Hospital
Tianjin (天津), China, 300052
First Affiliated Hospital of Medical College of Xi'an Jiaotong University
Xi'an, China, 710061
Xinjiang Uygur Autonomous Region People Hospital
Ürümqi, China, 830001 收起 <<
India
... 展开 >> Department of Clinical Immunology , Jawaharlal Institute of Post graduate Medical Educationa and Research
Recruiting
Pondicherry, India, 605006
Contact: Dr. Vir Singh Negi, DM 0413-2297358 vsnegi22@yahoo.co.in
Contact: Dr. Pooja Belani, MD 8940482248 drpoojabelani@gmail.com 收起 <<
China
... 展开 >> Peking University First Hospital
Beijing, China, 100034
Beijing Jishutan Hospital; Rheumatology & Immunology
Beijing, China, 100035
Peking University People's Hospital
Beijing, China, 100044
Peking University Third Hospital
Beijing, China, 100083
China-Janpan Friendship Hospital of Jilin University
Changchun, China, 130031
West China Hospital, Sichuan University
Chengdu, China, 610041
Sichuan Provincial People's Hospital
Chengdu, China, 610072
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, China, 510080
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, China, 510405
Nanfang Hospital, Southern Medical University
Guangzhou, China, 510515
Guanghua Hospital of Integrated Traditional Chinese and Western Medicine ( Guanghua Hospital)
Shanghai, China, 200052
The Second Hospital of Shanxi Medical University
Taiyuan, China, 030001
Tianjin Medical University General Hospital
Tianjin (天津), China, 300052
First Affiliated Hospital of Medical College of Xi'an Jiaotong University
Xi'an, China, 710061
Xinjiang Uygur Autonomous Region People Hospital
Ürümqi, China, 830001 收起 <<
Metastatic Castration Resistan... 展开 >>t Prostate Cancer (CRPC) 收起 <<
Phase 2
Unknown
-
Israel
... 展开 >> Bnei Tzion Medical Center
Recruiting
Haifa, Israel
Contact: Prof. Ofer Nativ ofer.nativ@b-zion.org.il
Principal Investigator: Prof. Ofer Nativ, MD
Rambam Medical Center
Recruiting
Haifa, Israel
Contact: Avivit Peer, MD a_peer@rambam.health.gov.il
Principal Investigator: Dr. Avivit Peer, MD
Sheba Medical Center
Recruiting
Tel Hashomer, Israel
Contact: Dr. Raanan Berger, M.D. Raanan.Berger@sheba.health.gov.il
Principal Investigator: Dr. Raanan Berger, MD, PhD
Sourasky Medical Center
Recruiting
Tel-Aviv, Israel
Contact: Dr. Eliahu Gez, MD eliahug@tasmc.health.gov.il
Principal Investigator: Dr. Eliahu Gez, MD
Asaf Harofe Medical Center
Recruiting
Tzrifin, Israel
Contact: Prof. Avishay Sella, MD Dr.AvishaySella@asaf.health.gov.il
Principal Investigator: Prof. Avishay Sella, MD 收起 <<
China
... 展开 >> Site CN00058
Recruiting
Inner Mongolia, China
Site CN00047
Recruiting
Shantou, China
Site CN00059
Recruiting
Wuhan, China
Site CN00049
Recruiting
Zhuzhou, China
Korea, Republic of
Site KR00037
Recruiting
Gwangju, Korea, Republic of
Site KR00036
Recruiting
Incheon, Korea, Republic of
Site KR00033
Recruiting
Seoul, Korea, Republic of
Site KR00034
Recruiting
Seoul, Korea, Republic of
Site KR00035
Recruiting
Seoul, Korea, Republic of
Taiwan
Site TW00025
Recruiting
Taipei, Taiwan
Site TW00026
Recruiting
Taipei, Taiwan 收起 <<
Sweden
... 展开 >> The Karolinska Institutet
Recruiting
Stockholm, Sweden, 171 76
Contact: Ronald van Vollenhoven, MD, Prof. +46(0)851776077 ronald.van.vollenhoven@ki.se 收起 <<
Finland
... 展开 >> Rheumatism Foundation Hospital
Heinola, Finland
Hospital for Children and Adolescents
Helsinki, Finland
Kuopio University Hospital
Kuopio, Finland
Oulu University Central Hospital
Oulu, Finland
Tampere University Hospital
Tampere, Finland
Turku University Hospital
Turku, Finland 收起 <<
Denmark
... 展开 >> Dept. of Rheumatology at Odense University Hospital
Recruiting
Odense, Denmark, 5000
Contact: Torkell J. Ellingsen, Prof PhD torkell.ellingsen@rsyd.dk
Contact: Maja S. Kragsnaes, PhD student maja.kragsnaes@dadlnet.dk
Sub-Investigator: Maja S. Kragsnaes, PhD student
Principal Investigator: Torkell J. Ellingsen, Prof PhD
Diagnostic Centre at Silkeborg Regional Hospital
Not yet recruiting
Silkeborg, Denmark, 8600
Contact: Maja S. Kragsnaes, PhD student 收起 <<
France
... 展开 >> Investigational Site Number 250007
Recruiting
Argenteuil, France
Investigational Site Number 250006
Recruiting
Besancon, France, 25030
Investigational Site Number 250027
Recruiting
Bobigny, France, 93000
Investigational Site Number 250016
Recruiting
Bordeaux, France, 33076
Investigational Site Number 250014
Recruiting
Caen, France, 14033
Investigational Site Number 250019
Recruiting
Cannes, France, 06414
Investigational Site Number 250013
Recruiting
Cholet, France, 49325
Investigational Site Number 250002
Recruiting
Clermont Ferrand, France, 63003
Investigational Site Number 250009
Recruiting
Echirolles, France, 38434
Investigational Site Number 250005
Recruiting
La Roche Sur Yon, France, 85025
Investigational Site Number 250004
Recruiting
Lille Cedex, France, 59037
Investigational Site Number 250012
Recruiting
Limoges Cedex, France, 87000
Investigational Site Number 250021
Recruiting
Lyon, France, 69495
Investigational Site Number 250018
Recruiting
Montivilliers, France
Investigational Site Number 250029
Recruiting
MONTPELLIER Cedex 5, France, 34295
Investigational Site Number 250025
Recruiting
NANTES Cedex 1, France, 44035
Investigational Site Number 250026
Recruiting
Nice cedex 1, France, 06001
Investigational Site Number 250020
Recruiting
Paris Cedex 10, France, 75475
Investigational Site Number 250011
Recruiting
PARIS Cedex 13, France, 75013
Investigational Site Number 250010
Recruiting
Paris, France, 75012
Investigational Site Number 250015
Recruiting
Paris, France, 75014
Investigational Site Number 250028
Recruiting
Paris, France, 75015
Investigational Site Number 250031
Recruiting
Poitiers, France, 86021
Investigational Site Number 250023
Recruiting
Pontoise, France, 95300
Investigational Site Number 250017
Recruiting
RENNES Cedex, France, 35022
Investigational Site Number 250008
Recruiting
Rouen, France, 76000
Investigational Site Number 250001
Recruiting
St Etienne, France, 42055
Investigational Site Number 250022
Recruiting
Toulouse, France, 31200
Investigational Site Number 250003
Recruiting
Tours, France, 37000 收起 <<
United States, Kentucky
... 展开 >>
University of Louisville
Recruiting
Louisville, Kentucky, United States, 40202
Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu
Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu
Sub-Investigator: Forest Arnold, DO
Sub-Investigator: Timothy Wiemkwn, PhD
Sub-Investigator: Robert Kelley, PhD
Sub-Investigator: James Summersgill, PhD
Sub-Investigator: Ruth Carrico, PhD
Sub-Investigator: Julie Harting, PharmD
Sub-Investigator: Paula Peyrani, MD
Principal Investigator: David Seligson, MD
Sub-Investigator: Craig Roberts, MD
Principal Investigator: Julio Ramirez, MD 收起 <<
Germany
... 展开 >> Asklepios Klinikum Bad Abbach
Recruiting
Bad Abbach, Germany
Contact: Martin Fleck, Prof. Dr. med.
Rheumapraxis Manger
Recruiting
Bamberg, Germany
Contact: Karin Manger, Prof. Dr. med.
Rheumapraxis Bayreuth
Recruiting
Bayreuth, Germany
Contact: Wolfgang Ochs, Dr. med.
Contact: Matthias Schmitt-Haendle, Dr. med.
Schlosspark-Klinik
Recruiting
Berlin, Germany
Contact: Rieke Alten, Dr. med.
Schwerpunktpraxis für Rheumatologie Burghausen
Recruiting
Burghausen, Germany
Contact: Martin Feuchtenberger, Dr. med.
PGRN.de Praxisgemeinschaft Rheumatologie Nephrologie
Recruiting
Erlangen, Germany
Contact: Joerg Wendler, Dr. med.
Contact: Florian Schuch, Dr. med.
Sub-Investigator: Stefan Kleinert, Dr. med.
Universitätsklinikum Heidelberg; Medizinische Klinik V
Recruiting
Heidelberg, Germany
Contact: Hanns-Martin Lorenz, Prof. Dr. med.
Gemeinschaftspraxis Dres. Demary und von Hinüber
Recruiting
Hildesheim, Germany
Contact: Winfried Demary, Dr. med.
Praxiszentrum St. Bonifatius
Recruiting
München, Germany
Contact: Klaus Krüger, Prof. Dr. med.
Praxis Professor Nüsslein
Recruiting
Nürnberg, Germany
Contact: Hubert Nüsslein, Prof. Dr. med.
Universitätsklinikum Tübingen; Zentrum für Interdisziplinäre Klinische Immunologie, Rheumatologie und Autoimmunerkrankungen - INDIRA
Recruiting
Tübingen, Germany
Contact: Joerg Henes, Dr. med.
Medizinische Klinik 2 und Poliklinik, Universitätsklinikum Würzburg
Recruiting
Würzburg, Germany
Contact: Hans-Peter Tony, Prof.Dr.med.
Contact: Marc Schmalzing, Dr. med. 收起 <<
Argentina
... 展开 >> Consultorios Especializados en Investigaciones Medicas
Capital Federal, Buenos Aires, Argentina, C1425EKF
CER San Juan
San Juan, Provinica de San Juan, Argentina, 5400
Instituto CAICI
Rosario, Santa Fe, Argentina, S2000PBJ
OMI
Buenos Aires, Argentina, 1015
Centro de Investigaciones en Enfermedades Reumaticas
Buenos Aires, Argentina, 1055
Hospital Britanico
Buenos Aires, Argentina, 1280
Atencion Integral en Reumatologia
Buenos Aires, Argentina, 1426
Investigaciones Reumatológicas y Osteológicas
Ciudad Autónoma de Buenos Aires, Argentina, C1114AAH
Centro de Osteopatías Médicas
Ciudad Autónoma de Buenos Aires, Argentina, C1128AAF
Sanatorio Mayo
Cordoba, Argentina, 5000
Hospital Escuela Gral. San Martin
Corrientes, Argentina, 3400
Centro Medico Privado de Reumatologia
San Miguel de Tucuman, Argentina, 4000
Centro de Investigaciones Reumatologicas
Tucuman, Argentina, 4000
Chile
Dr Miranda Private Practice
Santiago, Region Metropolitana, Chile
Hospital del Salvador
Santiago, Region Metropolitana, Chile
Colombia
Reumalab
Medellin, Antioquia, Colombia
Centro de Reumatologia y Ortopedia
Barranquilla, Atlantico, Colombia
IPS Centro Integral de Rematología del Caribe S.A.S CIRCARIBE S.A.S Sede 1
Barranquilla, Atlantico, Colombia
IPS Centro Integral de Rematología del Caribe S.A.S CIRCARIBE S.A.S Sede 2
Barranquilla, Atlantico, Colombia
Centro Integral de Reumatologia e Inmunologia LTDA
Bogota, Cundinamarca, Colombia, 0000
Foqus Ips Ltda
Bogota, Cundinamarca, Colombia
Fundacion Instituto de Reumatologia Fernando Chalem
Bogota, Cundinamarca, Colombia
Riesgo de fractura S.A. Clinica de Artritis y Rehabilitacion
Bogota, Cundinamarca, Colombia
Preventive Care Ltda
Chia, Cundinamarca, Colombia
Centro Medico Carlos Ardila Lulle
Bucaramanga, Santander, Colombia
Servimed EU
Bucaramanga, Santander, Colombia
Mexico
Hospital Angeles Chapalita
Guadajara, Jalisco, Mexico, 45040
Centro de Especialidades Medicas del Sureste SA de CV
Merida, Yucatan, Mexico
Centro de Investigación y Biomedicina de Chihuahua
Chihuahua, Mexico, 31000
Hospital Christus Mugerza
Chihuahua, Mexico, 31000
Hospital Christus Muguerza del Parque
Chihuahua, Mexico, 31000
Panama
Centro de Infusion Marbella
Panama, Panama
Centro de Investigacion Marbella
Panama, Panama 收起 <<
United Kingdom
... 展开 >> Newcastle NIHR Clinical Research Facility, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, Tyne & Wear, United Kingdom, NE1 4LP 收起 <<
China, Shandong
... 展开 >>
Department of Hematology of the 2nd Hospital of Shandong University
Recruiting
Jinan, Shandong, China, 250033
Contact: chengyun zheng, Ph. D +86-531-85875635 chengyun.zheng@ki.se
Sub-Investigator: Ni Zhang 收起 <<
United States, Maryland
... 展开 >>
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Bethesda, Maryland, United States, 20892 收起 <<
France
... 展开 >> Assistance Publique Des Hopitaux de Marseille
Recruiting
Marseille, Paca, France, 13354
Contact: MICHAEL BENZAQUEN +33 491964962 MICHAEL.BENZAQUEN@ap-hm.fr 收起 <<
Sweden
... 展开 >> Dept of Rheumatology and Inflammation research
Recruiting
Gothenburg, Sweden
Contact: Sofia T Silfverswärd sofia.silfversward@rheuma.gu.se 收起 <<
Japan
... 展开 >> Investigational Site Number 392010
Asahi-Shi, Japan
Investigational Site Number 392001
Asahikawa-Shi, Japan
Investigational Site Number 392070
Beppu-Shi, Japan
Investigational Site Number 392036
Chiba-Shi, Japan
Investigational Site Number 392083
Chuo-Ku, Japan
Investigational Site Number 392004
Fukui-Shi, Japan
Investigational Site Number 392039
Fukuoka-Shi, Japan
Investigational Site Number 392030
Ichinomiya-Shi, Japan
Investigational Site Number 392002
Iizuka-Shi, Japan
Investigational Site Number 392019
Kagoshima-Shi, Japan
Investigational Site Number 392066
Kamakura-Shi, Japan
Investigational Site Number 392050
Kato-Shi, Japan
Investigational Site Number 392037
Kawachi-Nagano-Shi, Japan
Investigational Site Number 392099
Kawasaki-Shi, Japan
Investigational Site Number 392013
Kitakyushu-Shi, Japan
Investigational Site Number 392097
Kochi-Shi, Japan
Investigational Site Number 392065
Kushiro-Shi, Japan
Investigational Site Number 392026
Matsuyama-Shi, Japan
Investigational Site Number 392034
Miyagi-Gun, Japan
Investigational Site Number 392076
Nagoya-Shi, Japan
Investigational Site Number 392080
Nagoya-Shi, Japan
Investigational Site Number 392046
Narashino-Shi, Japan
Investigational Site Number 392059
Oita-Shi, Japan
Investigational Site Number 392062
Okayama-Shi, Japan
Investigational Site Number 392027
Osaki-Shi, Japan
Investigational Site Number 392049
Sagamihara-Shi, Japan
Investigational Site Number 392014
Sapporo-Shi, Japan
Investigational Site Number 392041
Sapporo-Shi, Japan
Investigational Site Number 392073
Sapporo-Shi, Japan
Investigational Site Number 392006
Sasebo-Shi, Japan
Investigational Site Number 392021
Sendai-Shi, Japan
Investigational Site Number 392022
Sendai-Shi, Japan
Investigational Site Number 392033
Sendai-Shi, Japan
Investigational Site Number 392071
Sendai-Shi, Japan
Investigational Site Number 392029
Shizuoka-Shi, Japan
Investigational Site Number 392023
Takaoka-Shi, Japan
Investigational Site Number 392003
Tomakomai-Shi, Japan
Investigational Site Number 392074
Urasoe-Shi, Japan
Investigational Site Number 392079
Urayasu-Shi, Japan
Investigational Site Number 392048
Yokohama-Shi, Japan 收起 <<
Ireland
... 展开 >> Department of Surgery, St. James's Hospital
Dublin, Ireland, D4
Wellcome Trust-Health Research Board Clinical Research Facility, St. James's Hospital
Dublin, Ireland, D8 收起 <<
Greece
... 展开 >> District Gen. Hosp. of Athens Laiko; A Propedeutic Internal Medicine Clinic & Research Center
Athens, Greece, 115 27
Laiko General Hospital; Dept. of Pathophysiology-Uni of Athens
Athens, Greece, 115 27
Hippokratio Hospital; 2Nd Internal Medicine
Athens, Greece, 11527
ATTIKO Hospital_4th University Internal Medicine Clinic
Haidari, Greece, 124 62
Uni General Hospital of Heraklion; Medicine and Rheumatology Clinical Immunology and Allergy Dept
Heraklion, Greece, 711 10
Uni Hospital of Ioannina; Rheumatology
Ioannina, Greece, 455 00
University General Hospital of Larissa; Rheumatology Unit
Larissa, Greece, 411 10
University Hospital of Patras; Rheumatology
Patras, Greece, 265 04
EUROMEDICA Geniki Kliniki Thessalonikis; Rheumatology Department
Thessaloniki, Greece, 544 65
General Hospital of Thessaloniki HIPPOKRATIO; Clinical Immunology Unit,2nd Dept of Internal Medicine
Thessaloniki, Greece, 546 42 收起 <<
Australia, South Australia
... 展开 >>
Southern Adelaide Local Health Network
Recruiting
Bedford Park, South Australia, Australia, 5042
Contact: Arduino Mangoni, MD, PhD 收起 <<
Finland
... 展开 >> Rheumatism Foundation Hospital
Heinola, Finland, FI-18120
Helsinki University Central Hospital
Helsinki, Finland, FI-00029 HUS
Orton Invalid Foundation Hospital
Helsinki, Finland, FI-00280
Hämeenlinna Central Hospital
Hämeenlinna, Finland, FI-13530
Jyväskylä Central Hospital
Jyväskylä, Finland, FI-40620
Kuopio University Hospital
Kuopio, Finland, FI-703211
Lappeenranta Central Hospital
Lappeenranta, Finland, FI-53130
Oulu University Hospital
Oulu, Finland, FI-90029 OYS
Satakunta Central Hospital
Rauma, Finland, FI-26100
Rovaniemi Central Hospital
Rovaniemi, Finland, FI-96100
Seinäjoki Central Hospital
Seinäjoki, Finland, FI-60220
Tampere University Hospital
Tampere, Finland, FI-33521
Turku University Central Hospital
Turku, Finland, FI-21540 收起 <<
Finland
... 展开 >> Helsinki University Central Hospital
Recruiting
Helsinki, Finland
Contact: Tuomo Nieminen tuomo.vm.nieminen@helsinki.fi
Päijät-Häme Central Hospital
Recruiting
Lahti, Finland
Contact: Anne Kerola anne.kerola@helsinki.fi 收起 <<
United States, Maryland
... 展开 >>
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Bethesda, Maryland, United States, 20892 收起 <<
Japan
... 展开 >>
Asahikawa, Japan
Fukuoka, Japan
Hiroshima, Japan
Hitachinaka, Japan
Kagoshima, Japan
Kirishima, Japan
Kitakyushu, Japan
Kobe, Japan
Kumamoto, Japan
Matsumoto, Japan
Miyagi, Japan
Oita, Japan
Sapporo, Japan
Sendai, Japan
Shizuoka, Japan
Tokyo, Japan
Yokohama, Japan 收起 <<
United States, California
... 展开 >>
University of California, Davis
Recruiting
Davis, California, United States, 95616
Contact: Sandeep Dhaliwal
Principal Investigator: Chris Bowlus, MD
United States, Florida
University of Miami
Recruiting
Miami, Florida, United States, 33136
Contact: Andrea Elibero
Principal Investigator: Cynthia Levy, MD
Sub-Investigator: Diane Sabogal, MD
United States, Massachusetts
Brigham and Women's Hospital
Recruiting
Boston, Massachusetts, United States, 02115
Contact: Fernanda Quevedo 617-732-9676 squevedo@bwh.harvard.edu
Principal Investigator: Joshua Korzenik, MD
United States, Michigan
Henry Ford Health System
Recruiting
Detroit, Michigan, United States, 48202
Contact: Donna Rush
Principal Investigator: Stuart Gordon, MD
United States, North Carolina
Duke University
Recruiting
Durham, North Carolina, United States, 27710
Contact: Stacey Smith
Principal Investigator: Andrew Muir
United States, Pennsylvania
University of Pennsylvania
Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Maureen Mccauley
Principal Investigator: David Goldberg, MD 收起 <<
Terminated(Study terminated on... 展开 >> 13 April 2016 for business reasons. No safety and/or efficacy concerns contributed to the termination of the study) 收起 <<
-
United States, Ohio
... 展开 >>
University Hospitals Case Medical Center
Cleveland, Ohio, United States, 44106
Mexico
Private Office
Guadalajara, Jalisco, Mexico, 44650 收起 <<
Terminated(Study terminated on... 展开 >> 13 April 2016 for business reasons. No safety and/or efficacy concerns contributed to the termination of the study) 收起 <<
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