Sulfasalazine
产品说明书
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同义名 : | 柳氮磺胺吡啶 ;NSC 667219;Azopyrin;Rorasul;Reupirin;NSC-203730 NSC 203730;NSC 203730;Sulphasalazine |
| CAS号 : | 599-79-1 | |
| 货号 : | A176325 | |
| 分子式 : | C18H14N4O5S | |
| 纯度 : | 98% | |
| 分子量 : | 398.39 | |
| MDL号 : | MFCD00057363 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 85 mg/mL(213.36 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO NH4OH: 150 mg/mL(376.52 mM)，配合低频超声，并调节pH至9 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Sulfasalazine is a potent and specific inhibitor of NF-kappaB activation. Treatment of SW620 colon cells with sulfasalazine inhibited TNFalpha-, LPS-, or phorbol ester- induced NF-kappaB activation. NF-kappaB-dependent transcription was inhibited by sulfasalazine at micro- to millimolar concentrations. TNFalpha-induced nuclear translocation of NF-kappaB was prevented by sulfasalazine through inhibition of IkappaBalpha degradation[3]. Sulfasalazine is a direct inhibitor of IKK-alpha and -beta by antagonizing adenosine triphosphate binding. The suppression of NF-kappaB activation by inhibition of the IKKs contributes to the well-known anti-inflammatory and immunosuppressive effects of sulfasalazine[4]. Sulfasalazine can inhibit NF-κB and reduce lipopolysaccharide-induced cytokine concentrations in fetal membrane explants and reduce the rate of Escherichia coli-induced preterm labour in mice[5]. Sulfasalazine induces cell death via apoptosis in HBx-expressing liver cells, as evidenced by characteristic changes in nuclear morphology, cleavage of poly (ADP-ribose) polymerase (PARP), caspase-3 and caspase-9, and activation of caspase-3[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02930343 | Rheumatoid Arthritis | Phase 4 | Recruiting | August 2018 | India ... 展开 >> Department of Clinical Immunology , Jawaharlal Institute of Post graduate Medical Educationa and Research Recruiting Pondicherry, India, 605006 Contact: Dr. Vir Singh Negi, DM 0413-2297358 vsnegi22@yahoo.co.in Contact: Dr. Pooja Belani, MD 8940482248 drpoojabelani@gmail.com 收起 << |
| NCT02590562 | - | Completed | - | China ... 展开 >> Peking University First Hospital Beijing, China, 100034 Beijing Jishutan Hospital; Rheumatology & Immunology Beijing, China, 100035 Peking University People's Hospital Beijing, China, 100044 Peking University Third Hospital Beijing, China, 100083 China-Janpan Friendship Hospital of Jilin University Changchun, China, 130031 West China Hospital, Sichuan University Chengdu, China, 610041 Sichuan Provincial People's Hospital Chengdu, China, 610072 The First Affiliated Hospital, Sun Yat-sen University Guangzhou, China, 510080 The First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou, China, 510405 Nanfang Hospital, Southern Medical University Guangzhou, China, 510515 Guanghua Hospital of Integrated Traditional Chinese and Western Medicine ( Guanghua Hospital) Shanghai, China, 200052 The Second Hospital of Shanxi Medical University Taiyuan, China, 030001 Tianjin Medical University General Hospital Tianjin (天津), China, 300052 First Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an, China, 710061 Xinjiang Uygur Autonomous Region People Hospital Ürümqi, China, 830001 收起 << | |
| NCT02590562 | - | Completed | - | - | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.51mL 0.50mL 0.25mL |
12.55mL 2.51mL 1.26mL |
25.10mL 5.02mL 2.51mL |
| 参考文献 |
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