Stevioside, a natural product isolated and purified from the leaves of Stevia rebaudiana, is a safe natural sweetener, has no allergic reactions, suited for both diabetics, and PKU patients, as well as for obese persons intending to lose weight by avoiding sugar supplements in the diet. Stevioside also exerts anti-inflammatory and anti-apoptotic properties by inhibiting the release of cytokines and the activation of TLR2 and proteins of the NF-κB and MAPK signaling pathways, as well as caspase-3 and Bax. Stevioside and steviol attenuate LPS-induced pro-inflammatory cytokine productions by affecting cytokine gene expression via IκBα/NF-κB signalling pathway.
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产品名称 | NF-κB ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PDTC ammonium | ✔ | 98% | |||||||||||||||||
QNZ |
++++
NF-κB, IC50: 11 nM |
99%+ | |||||||||||||||||
Sodium 4-Aminosalicylate Dihydrate | ✔ | 98% | |||||||||||||||||
Sodium Salicylate | ✔ | 95% | |||||||||||||||||
Parthenolide | ✔ | p53 | 97% HPLC | ||||||||||||||||
JSH-23 |
+
NF-κB, IC50: 7.1 μM |
98% | |||||||||||||||||
Phenethyl caffeate | ✔ | 98% | |||||||||||||||||
Andrographolide | ✔ | 98+% | |||||||||||||||||
Curcumin | ✔ | HDAC,Nrf2 | 98% | ||||||||||||||||
SC75741 |
+++
NF-κB, EC50: 200 nM |
99%+ | |||||||||||||||||
CBL0137 HCl |
++
NF-κB, EC50: 0.47 μM |
p53 | 99%+ | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Stevioside is obtained from leaves of Stevia rebaudiana. Stevioside is an important source of biochemically active substances with proven anti-diabetic effect. Stevioside solution prevented significant increase in glycaemia in oral glucose tolerance test (9.22 ± 1.13 to 9.85 ± 1.32 mmol/l, P < 0.05), and not in adrenaline test[3]. Stevioside inhibited the mRNA and protein expression of TNF-α, IL-6 and IL-1β dose-dependently in S.aureus-stimulated MMECs. Stevioside suppressed the S.aureus-induced expression of TLR2 and proteins of the NF-κB and MAPK pathways as well as apoptosis[4]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02880124 | Carbohydrate Ingestion ... 展开 >> Fuel Selection Athletic Performance 收起 << | Not Applicable | Recruiting | December 2017 | Canada, Quebec ... 展开 >> Centre d'éducation physique et sportive de l'Université de Montréal (CEPSUM) Recruiting Montréal, Quebec, Canada, H3C 3J7 Contact: Mélanie F Paradis, M.Sc. 514-571-4122 melanie.paradis@umontreal.ca Contact: Lorianne Lavoie, B.Sc. 514-466-3393 lorianne.lavoie@umontreal.ca Principal Investigator: Jonathan Tremblay, Ph.D. 收起 << |
NCT02634164 | Hyperglycemia | Not Applicable | Completed | - | - |
NCT03115385 | Obesity, Abdominal ... 展开 >> Adiposity 收起 << | Not Applicable | Terminated(Funds ended.) | - | United States, California ... 展开 >> University of Southern California Los Angeles, California, United States, 90033 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.24mL 0.25mL 0.12mL |
6.21mL 1.24mL 0.62mL |
12.42mL 2.48mL 1.24mL |
CAS号 | 57817-89-7 |
分子式 | C38H60O18 |
分子量 | 804.872 |
别名 | 甜菊苷 |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Sealed in dry,2-8°C |
溶解度 |
DMSO: 250 mg/mL(310.61 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |