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Stevioside

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Chemical Structure| 57817-89-7 同义名 : 甜菊苷
CAS号 : 57817-89-7
货号 : A105391
分子式 : C38H60O18
纯度 : 95%
分子量 : 804.872
MDL号 : MFCD00079561
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(310.61 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Stevioside is obtained from leaves of Stevia rebaudiana. Stevioside is an important source of biochemically active substances with proven anti-diabetic effect. Stevioside solution prevented significant increase in glycaemia in oral glucose tolerance test (9.22 ± 1.13 to 9.85 ± 1.32 mmol/l, P < 0.05), and not in adrenaline test[3]. Stevioside inhibited the mRNA and protein expression of TNF-α, IL-6 and IL-1β dose-dependently in S.aureus-stimulated MMECs. Stevioside suppressed the S.aureus-induced expression of TLR2 and proteins of the NF-κB and MAPK pathways as well as apoptosis[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02880124 Carbohydrate Ingestion ... 展开 >> Fuel Selection Athletic Performance 收起 << Not Applicable Recruiting December 2017 Canada, Quebec ... 展开 >> Centre d'éducation physique et sportive de l'Université de Montréal (CEPSUM) Recruiting Montréal, Quebec, Canada, H3C 3J7 Contact: Mélanie F Paradis, M.Sc.    514-571-4122    melanie.paradis@umontreal.ca    Contact: Lorianne Lavoie, B.Sc.    514-466-3393    lorianne.lavoie@umontreal.ca    Principal Investigator: Jonathan Tremblay, Ph.D. 收起 <<
NCT02634164 Hyperglycemia Not Applicable Completed - -
NCT03115385 Obesity, Abdominal ... 展开 >> Adiposity 收起 << Not Applicable Terminated(Funds ended.) - United States, California ... 展开 >> University of Southern California Los Angeles, California, United States, 90033 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.24mL

0.25mL

0.12mL

6.21mL

1.24mL

0.62mL

12.42mL

2.48mL

1.24mL
参考文献

[1]Wang T, Song X, et al. Stevioside inhibits inflammation and apoptosis by regulating TLR2 and TLR2-related proteins in S. aureus-infected mouse mammary epithelial cells. Int Immunopharmacol. 2014 Sep;22(1):192-9.

[2]Boonkaewwan C, Burodom A. Anti-inflammatory and immunomodulatory activities of stevioside and steviol on colonic epithelial cells. J Sci Food Agric. 2013 Dec;93(15):3820-5.

[3]Ilić V, Vukmirović S, Stilinović N, Čapo I, Arsenović M, Milijašević B. Insight into anti-diabetic effect of low dose of stevioside. Biomed Pharmacother. 2017 Jun;90:216-221. doi: 10.1016/j.biopha.2017.03.045. Epub 2017 Mar 28. PMID: 28363166.

[4]Wang T, Song X, Zhang Z, Guo M, Jiang H, Wang W, Cao Y, Zhu L, Zhang N. Stevioside inhibits inflammation and apoptosis by regulating TLR2 and TLR2-related proteins in S. aureus-infected mouse mammary epithelial cells. Int Immunopharmacol. 2014 Sep;22(1):192-9. doi: 10.1016/j.intimp.2014.06.015. Epub 2014 Jun 27. PMID: 24975657.