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Ro 10-5824 2HCl

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Chemical Structure| 189744-94-3 同义名 : Ro 10-5824 dihydrochloride
CAS号 : 189744-94-3
货号 : A747660
分子式 : C17H22Cl2N4
纯度 : 99%+
分子量 : 353.289
MDL号 : MFCD08703115
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 7 mg/mL(19.81 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(283.05 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Ro 10-5824 2HCl is a partial agonist of the Dopamine D4 receptor, exhibiting high-affinity binding with a Ki value of 5.2±0.9 nM. It is 250 times more selective for the human D3R receptor and >1000 times more selective for the D4 receptor compared to human D2, D1, and D5 receptors. Ro 10-5824 2HCl stimulates 35S-GTPγS binding with an EC50 value of 205±67 nM, with a maximum induction above baseline of 36±4%[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.83mL

0.57mL

0.28mL

14.15mL

2.83mL

1.42mL

28.31mL

5.66mL

2.83mL
参考文献

[1]Powell SB, et al. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology. 2003 Mar;44(4):473-81.

[2]Nakazawa S, et al. Behavioral and neurophysiological effects of Ro 10-5824, a dopamine D4 receptor partial agonist, in common marmosets. Psychopharmacology (Berl). 2015 Sep;232(17):3287-95.