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/ 肾上腺素能受体 / Ritodrine HCl

盐酸利托君 /Ritodrine HCl {[allProObj[0].p_purity_real_show]}

货号：A444012 同义名： 利托君盐酸盐 / DU21220 hydrochloride;Ritodrine (hydrochloride)

Ritodrine HCl通过与子宫肌膜细胞外膜上的 β-2 肾上腺素能受体结合激活 β-2 肾上腺素能受体，用于阻止早产。

Ritodrine HCl 化学结构 CAS号：23239-51-2
Ritodrine HCl 化学结构
CAS号：23239-51-2
Ritodrine HCl 3D分子结构
CAS号：23239-51-2
Ritodrine HCl 化学结构 CAS号：23239-51-2
Ritodrine HCl 3D分子结构 CAS号：23239-51-2
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Ritodrine HCl 纯度/质量文件 产品仅供科研

货号：A444012 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Adrenergic Receptor ↓ α-adrenergic receptor ↓ β-adrenergic receptor ↓ 其他靶点 纯度
Ivabradine HCl ✔ 98%
Maprotiline hydrochloride ✔ 98%
Cisatracurium besylate ✔ 96%
Yohimbine HCI ✔ 99+%
BMY 7378 ++

α2C-adrenoceptor, pKi: 6.54

α1D-adrenoceptor, pKi: 5.1

 		+

β1-adrenoceptor, pIC50: 5.1

 		97%
Asenapine maleate ++++

α2B-adrenergic receptor, pKi: 8.9

α2A-adrenergic receptor, pKi: 8.9

 		97%
Piribedil ++

adrenoceptor α2A, pKi: 7.1

adrenoceptor α2C, pKi: 7.2

 		98%
Prazosin HCl ✔ 95%
Silodosin ✔ 98%
Phenoxybenzamine HCl ✔ 98%
Naftopidil +++

α1A-adrenergic receptor, Ki: 3.7 nM

α1D-adrenergic receptor, Ki: 20 nM

 		98%
Naftopidil 2HCl +

α1-adrenergic receptor, IC50: 0.2 μM

 		99%
Alfuzosin HCl ✔ 98%
Terazosin HCl ✔ 99%
Atipamezole ✔ 95%
Phentolamine methanesulfonate salt ✔ 99%
Doxazosin mesylate ✔ 99%
Tolazoline HCl ✔ 98%
Zenidolol hydrochloride ++++

β1-adrenergic receptor, Ki: 611nM

β2-adrenergic receptor, Ki: 0.7nM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ritodrine HCl 生物活性

描述 Ritodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist. In treating preterm labour, ritodrine can significantly prolong a short interval more quickly but with relatively more side effects than magnesium sulphate[3]. Multivariable analysis showed that the total dose of ritodrine was significantly associated with pulmonary oedema. Consideration of the total dose of ritodrine hydrochloride is helpful in the management of patients with threatened preterm labour in twin pregnancy[4]. However, long-term tocolysis with intravenous infusion of ritodrine hydrochloride, a betamimetic, can be selected as the first-line tocolytic treatment in Japan[5].

Ritodrine HCl 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03298191 Preterm Labor Without Delivery Phase 4 Recruiting May 25, 2018 Egypt ... 展开 >> Mohamed Atef Mohamed Recruiting Sohag, Egypt Contact: mohamed mohamed    +01005537951    mohammedelksoy@yahoo.com 收起 <<
NCT00679705 Healthy Phase 1 Completed - Belgium ... 展开 >> University Hospital Ghent Ghent, Belgium, 9000 收起 <<
NCT02538718 Preterm Labor Not Applicable Recruiting - Korea, Republic of ... 展开 >> Seoul National University Hospital Recruiting Seoul, Korea, Republic of, 110744 Contact: Joong Shin Park, MD PhD          Seoul Metropolitan Goverment Seoul National University Boramae Medical Center Recruiting Seoul, Korea, Republic of, 156707 Contact: Byung Jae Kim, M.D, Ph.D.       bjkimmd7@snu.ac.kr 收起 <<

Ritodrine HCl 参考文献

[1]Onishi H, Sakata O, et al. In vitro and in vivo evaluations of buccal tablet formulations of ritodrine hydrochloride. Biol Pharm Bull. 2015;38(6):919-25.

[2]Sakata O, Onishi H. In vivo absorption study of ritodrine hydrochloride in the buccal administration to rats. Drug Dev Ind Pharm. 2013 Sep;39(9):1414-20.

[3]Li X, Zhang Y, Shi Z. Ritodrine in the treatment of preterm labour: a meta-analysis. Indian J Med Res. 2005;121(2):120-127

[4]Shinohara S, Sunami R, Uchida Y, Hirata S, Suzuki K. Association between total dose of ritodrine hydrochloride and pulmonary oedema in twin pregnancy: a retrospective cohort study in Japan. BMJ Open. 2017;7(12):e018118.

[5]Shigemi D, Aso S, Yasunaga H. Inappropriate use of ritodrine hydrochloride for threatened preterm birth in Japan: a retrospective cohort study using a national inpatient database. BMC Pregnancy Childbirth. 2019;19(1):204.

Ritodrine HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.09mL

0.62mL

0.31mL

15.44mL

3.09mL

1.54mL

30.88mL

6.18mL

3.09mL

Ritodrine HCl 技术信息

CAS号23239-51-2
分子式C17H22ClNO3
分子量 323.815
别名 利托君盐酸盐 ;DU21220 hydrochloride;Ritodrine (hydrochloride);(±)-Ritodrine;NSC 291565;DU 21220;Ritodrine hydrochloride
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 115 mg/mL(355.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(308.82 mM)
动物实验配方

Tags: Ritodrine | 23239-51-2 | DU21220 | DU 21220 | DU-21220 | β2 Agonist | GPCR/G Protein | Neuronal Signaling | Adrenergic Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Ritodrine HCl 纯度/质量文件 | Ritodrine HCl 亚型比较 | Ritodrine HCl 生物活性 | Ritodrine HCl 临床数据 | Ritodrine HCl 参考文献 | Ritodrine HCl 实验方案 | Ritodrine HCl 技术信息

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