Rabeprazole, an antiulcer drug, can irreversibly inhibit gastric H+/K+ ATPase pump with IC50 of 72 nM.
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产品名称 | Proton Pump ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Zinc pyrithione | ✔ | 98+% | |||||||||||||||||
PF 03716556 |
++++
H+/K+-ATPase, pIC50: ~6.5 |
98% | |||||||||||||||||
Lansoprazole | ✔ | 98% | |||||||||||||||||
Esomeprazole Magnesium | ✔ | 98%+ | |||||||||||||||||
Rabeprazole | ✔ | 99%+ | |||||||||||||||||
Ilaprazole | ✔ | TOPK | 97% | ||||||||||||||||
Bafilomycin A1 |
++++
H+-ATPase, IC50: 0.44 nM |
95% | |||||||||||||||||
Pantoprazole sodium | ✔ | 98% | |||||||||||||||||
(R)-Lansoprazole | ✔ | 98% | |||||||||||||||||
Tenatoprazole | ✔ | 99%+ | |||||||||||||||||
Omeprazole | ✔ | 98% | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Rabeprazole is an antiulcer drug and selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 72 nM). |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT01408186 | Upper Gastrointestinal Bleedin... 展开 >>g 收起 << | Phase 3 | Completed | - | Hong Kong ... 展开 >> Prince of Wales Hospital Hong Kong, Hong Kong Japan Second Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan Izumo, Japan Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan Kyoto, Japan Department of Gastroenterology, Osaka City General Hospital, Osaka, Japan (Satellite hospital of Osaka City University) Osaka, Japan Department of Gastroenterology, Osaka City University Graduate School of Medicine Osaka, Japan Department of Gastroenterology, Takarazuka Municipal Hospital, Hyogo, Japan (Satellite hospital of Osaka City University) Osaka, Japan Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan Osaka, Japan Department of Internal Medicine and Gastroenterology, Saga Medical School, Saga, Japan Saga, Japan 收起 << |
NCT03658733 | Helicobacter Pylori Infection | Phase 4 | Not yet recruiting | October 31, 2019 | China, Shandong ... 展开 >> Xiuli Zuo Recruiting Jinan, Shandong, China Contact: Xiuli Zuo, PhD,MD 15588818685 ext 053188369277 zuoxiuli@sina.com Sub-Investigator: Yue Li, MD Sub-Investigator: Chaoran Ji, MD 收起 << |
NCT01918176 | Healthy | Phase 1 | Completed | - | United States, Florida ... 展开 >> Pfizer Investigational Site South Miami, Florida, United States, 33143 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.78mL 0.56mL 0.28mL |
13.91mL 2.78mL 1.39mL |
27.82mL 5.56mL 2.78mL |
CAS号 | 117976-89-3 |
分子式 | C18H21N3O3S |
分子量 | 359.443 |
别名 | LY307640 |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Inert atmosphere,2-8°C |
溶解度 | |
动物实验配方 |