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雷贝拉唑 /Rabeprazole {[allProObj[0].p_purity_real_show]}

货号:A229737 同义名: LY307640

Rabeprazole, an antiulcer drug, can irreversibly inhibit gastric H+/K+ ATPase pump with IC50 of 72 nM.

Rabeprazole 化学结构 CAS号:117976-89-3
Rabeprazole 化学结构
CAS号:117976-89-3
Rabeprazole 3D分子结构
CAS号:117976-89-3
Rabeprazole 化学结构 CAS号:117976-89-3
Rabeprazole 3D分子结构 CAS号:117976-89-3
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Rabeprazole 纯度/质量文件 产品仅供科研

货号:A229737 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

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产品名称 Proton Pump 其他靶点 纯度
Zinc pyrithione 98+%
PF 03716556 ++++

H+/K+-ATPase, pIC50: ~6.5

98%
Lansoprazole 98%
Esomeprazole Magnesium 98%+
Rabeprazole 99%+
Ilaprazole TOPK 97%
Bafilomycin A1 ++++

H+-ATPase, IC50: 0.44 nM

95%
Pantoprazole sodium 98%
(R)-Lansoprazole 98%
Tenatoprazole 99%+
Omeprazole 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Rabeprazole 生物活性

靶点
  • Proton Pump

描述 Rabeprazole is an antiulcer drug and selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 72 nM).

Rabeprazole 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01408186 Upper Gastrointestinal Bleedin... 展开 >>g 收起 << Phase 3 Completed - Hong Kong ... 展开 >> Prince of Wales Hospital Hong Kong, Hong Kong Japan Second Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan Izumo, Japan Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan Kyoto, Japan Department of Gastroenterology, Osaka City General Hospital, Osaka, Japan (Satellite hospital of Osaka City University) Osaka, Japan Department of Gastroenterology, Osaka City University Graduate School of Medicine Osaka, Japan Department of Gastroenterology, Takarazuka Municipal Hospital, Hyogo, Japan (Satellite hospital of Osaka City University) Osaka, Japan Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan Osaka, Japan Department of Internal Medicine and Gastroenterology, Saga Medical School, Saga, Japan Saga, Japan 收起 <<
NCT03658733 Helicobacter Pylori Infection Phase 4 Not yet recruiting October 31, 2019 China, Shandong ... 展开 >> Xiuli Zuo Recruiting Jinan, Shandong, China Contact: Xiuli Zuo, PhD,MD    15588818685 ext 053188369277    zuoxiuli@sina.com    Sub-Investigator: Yue Li, MD          Sub-Investigator: Chaoran Ji, MD 收起 <<
NCT01918176 Healthy Phase 1 Completed - United States, Florida ... 展开 >> Pfizer Investigational Site South Miami, Florida, United States, 33143 收起 <<

Rabeprazole 参考文献

[1]Yamasaki Y, Fujimura T, et al. Effects of rabeprazole on bone metabolic disorders in a gastrectomized rat model. Biomed Rep. 2016 Jul;5(1):118-124.

[2]Iwakiri R, Tominaga K, et al. Randomised clinical trial: rabeprazole improves symptoms in patients with functional dyspepsia in Japan. Aliment Pharmacol Ther. 2013 Oct;38(7):729-40.

Rabeprazole 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.91mL

2.78mL

1.39mL

27.82mL

5.56mL

2.78mL

Rabeprazole 技术信息

CAS号117976-89-3
分子式C18H21N3O3S
分子量 359.443
别名 LY307640
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C

溶解度
动物实验配方
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