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Rabeprazole

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Chemical Structure| 117976-89-3 同义名 : LY307640
CAS号 : 117976-89-3
货号 : A229737
分子式 : C18H21N3O3S
纯度 : 99%+
分子量 : 359.443
MDL号 : MFCD00868879
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • Proton Pump
描述 Rabeprazole is an antiulcer drug and selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 72 nM).
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01408186 Upper Gastrointestinal Bleedin... 展开 >>g 收起 << Phase 3 Completed - Hong Kong ... 展开 >> Prince of Wales Hospital Hong Kong, Hong Kong Japan Second Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan Izumo, Japan Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan Kyoto, Japan Department of Gastroenterology, Osaka City General Hospital, Osaka, Japan (Satellite hospital of Osaka City University) Osaka, Japan Department of Gastroenterology, Osaka City University Graduate School of Medicine Osaka, Japan Department of Gastroenterology, Takarazuka Municipal Hospital, Hyogo, Japan (Satellite hospital of Osaka City University) Osaka, Japan Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan Osaka, Japan Department of Internal Medicine and Gastroenterology, Saga Medical School, Saga, Japan Saga, Japan 收起 <<
NCT03658733 Helicobacter Pylori Infection Phase 4 Not yet recruiting October 31, 2019 China, Shandong ... 展开 >> Xiuli Zuo Recruiting Jinan, Shandong, China Contact: Xiuli Zuo, PhD,MD    15588818685 ext 053188369277    zuoxiuli@sina.com    Sub-Investigator: Yue Li, MD          Sub-Investigator: Chaoran Ji, MD 收起 <<
NCT01918176 Healthy Phase 1 Completed - United States, Florida ... 展开 >> Pfizer Investigational Site South Miami, Florida, United States, 33143 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.91mL

2.78mL

1.39mL

27.82mL

5.56mL

2.78mL
参考文献

[1]Yamasaki Y, Fujimura T, et al. Effects of rabeprazole on bone metabolic disorders in a gastrectomized rat model. Biomed Rep. 2016 Jul;5(1):118-124.

[2]Iwakiri R, Tominaga K, et al. Randomised clinical trial: rabeprazole improves symptoms in patients with functional dyspepsia in Japan. Aliment Pharmacol Ther. 2013 Oct;38(7):729-40.