Tenatoprazole
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货号：A463838
同义名：
TU-199
Tenatoprazole is a prodrug of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM.
Tenatoprazole 化学结构
Tenatoprazole 3D分子结构
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Tenatoprazole 纯度/质量文件 产品仅供科研
货号：A463838
标准纯度：
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Tenatoprazole 质控信息
Tenatoprazole 生物活性
靶点
描述
Tenatoprazole (TU-199) is an orally effective imidazopyridine-based proton pump inhibitor noted for its extended plasma half-life. It inhibits hog gastric H+/K+-ATPase activity with an IC50 of 6.2 μM and blocks the interaction between ubiquitin and the ESCRT-1 factor Tsg101, inhibiting the production of several enveloped viruses, including EBV[1] [2] [3]
体外研究
In Heidenhain-pouch dogs, Tenatoprazole dose-dependently reduces gastric acid secretion stimulated by histamine infusion at dosages of 0.1, 0.2, and 0.4 mg/kg[4]
Tenatoprazole 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT00282555
Esophagitis, Reflux
Phase 2
Suspended
-
Canada, Alberta
... 展开 >>
Calgary, Alberta, Canada
Edmonton, Alberta, Canada
Canada, British Columbia
Abbottsford, British Columbia, Canada
Vancouver, British Columbia, Canada
Canada, Manitoba
Winnipeg, Manitoba, Canada
Canada, Ontario
Guelph, Ontario, Canada
Hamilton, Ontario, Canada
Scarborough, Ontario, Canada
Toronto, Ontario, Canada
Windsor, Ontario, Canada
Canada, Quebec
Lévis, Quebec, Canada
Montreal, Quebec, Canada
Pointe-Claire, Quebec, Canada
Sherbrooke, Quebec, Canada
St-Charles-de-Borromée, Quebec, Canada
Canada, Saskatchewan
Saskatoon, Saskatchewan, Canada
Canada
Quebec, Canada 收起 <<
NCT00284908
Esophagitis
G... 展开 >> astroesophageal Reflux
Stomach Ulcer
Duodenal Ulcer 收起 <<
Phase 1
Completed
-
United States, Texas
... 展开 >>
Healthcare Discoveries, Inc.
San Antonio, Texas, United States, 78229 收起 <<
Tenatoprazole 参考文献
[1] Thomson AB, et al. Comparison of the effects of fasting morning, fasting evening and fed bedtime administration of tenatoprazole on intragastric pH in healthy volunteers: a randomized three-way crossover study. Aliment Pharmacol Ther. 2006;23(8):1179-1187.
[2] Uchiyama K, et al. Effects of TU-199, a novel H+, K(+)-ATPase inhibitor, on gastric acid secretion and gastroduodenal ulcers in rats. Methods Find Exp Clin Pharmacol. 1999;21(2):115-122.
[3] Mannemuddhu SS, et al. Prazoles Targeting Tsg101 Inhibit Release of Epstein-Barr Virus following Reactivation from Latency. J Virol. 2021;95(13):e0246620.
[4] Uchiyama K, et al. The long-lasting effect of TU-199, a novel H+, K(+)-ATPase inhibitor, on gastric acid secretion in dogs. J Pharm Pharmacol. 1999;51(4):457-464.
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Tenatoprazole 实验方案
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.89mL
0.58mL
0.29mL
14.43mL
2.89mL
1.44mL
28.87mL
5.77mL
2.89mL
Tenatoprazole 技术信息
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