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右旋兰索拉唑 /(R)-Lansoprazole {[allProObj[0].p_purity_real_show]}

货号：A414150 同义名： 右兰索拉唑 / Dexlansoprazole;T-168390

(R)-Lansoprazole, the dextrorotatory enantiomer of lansoprazole, can irreversibly inactivate the H+/K+-stimulated ATPase pump.

(R)-Lansoprazole 化学结构 CAS号：138530-94-6
(R)-Lansoprazole 化学结构
CAS号：138530-94-6
(R)-Lansoprazole 3D分子结构
CAS号：138530-94-6
(R)-Lansoprazole 化学结构 CAS号：138530-94-6
(R)-Lansoprazole 3D分子结构 CAS号：138530-94-6
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(R)-Lansoprazole 纯度/质量文件 产品仅供科研

货号：A414150 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Proton Pump ↓ 其他靶点 纯度
Zinc pyrithione ✔ 98+%
PF 03716556 ++++

H+/K+-ATPase, pIC50: ~6.5

 		98%
Lansoprazole ✔ 98%
Esomeprazole Magnesium ✔ 98%+
Rabeprazole ✔ 99%+
Ilaprazole ✔ TOPK 97%
Bafilomycin A1 ++++

H+-ATPase, IC50: 0.44 nM

 		95%
Pantoprazole sodium ✔ 98%
(R)-Lansoprazole ✔ 98%
Tenatoprazole ✔ 99%+
Omeprazole ✔ 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

(R)-Lansoprazole 生物活性

靶点

  • Proton Pump
描述 (R)-Lansoprazole is the R enantiomer of Lansoprazole. Lansoprazole (AG 1749) is an orally active proton pump inhibitor that suppresses gastric acid production. Additionally, Lansoprazole (AG 1749) is a potent brain-penetrating inhibitor of neutral sphingomyelinase (N-SMase), which also acts as an exosome inhibitor[1][2].
体外研究

The plasma concentrations of (R)-lansoprazole are notably elevated across all three CYP2C19 genotype groups compared to the corresponding (S)-enantiomer. In terms of AUC0-∞, Cmax, and elimination half-life, (R)-lansoprazole exhibits significantly higher values and longer durations compared to the (S)-enantiomer across all genotype groups[3].

(R)-Lansoprazole 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00274339 Laryngopharyngeal Reflux Not Applicable Unknown June 2008 United States, Kentucky ... 展开 >> Commonwealth Ear, Nose & Throat Recruiting Louisville, Kentucky, United States, 40207 Contact: Marti Gardner, MSN    502-893-0159 ext 1185    mgardner@commonwealthent.com    Principal Investigator: Kenneth M Hodge, MD          Sub-Investigator: John R Morris, MD          Sub-Investigator: Donald V Welsh, MD          Sub-Investigator: Gorden T McMurry, MD          Sub-Investigator: Andrew R Gould, MD          Sub-Investigator: Keith D Forwith, PhD, MD          Sub-Investigator: Steven D Shotts, MD          Sub-Investigator: Tamalynn O'Daniel, MSN, ARNP          Sub-Investigator: Jolene H Boswell, PA-C          Sub-Investigator: Mary S McLaughlin, PA-C          Sub-Investigator: Martha L Gardner, MSN, ARNP          Sub-Investigator: Brian Walker, PA-C 收起 <<
NCT02297126 Adverse Drug Reaction Not Applicable Completed - United States, Indiana ... 展开 >> Eskenazi Health System Indianapolis, Indiana, United States, 46250 收起 <<
NCT00237679 Voice Disorders ... 展开 >> Gastroesophageal Reflux 收起 << Not Applicable Terminated(Terminated due to f... 展开 >>unding loss.) 收起 << - United States, Wisconsin ... 展开 >> University of Wisconsin Madison, Wisconsin, United States, 53792 收起 <<

(R)-Lansoprazole 参考文献

[1]Kokufu, T., et al., Effects of lansoprazole on pharmacokinetics and metabolism of theophylline. Eur J Clin Pharmacol, 1995. 48(5): p. 391-5.

[2]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.

[3]M Miura, et al. Pharmacokinetic differences between the enantiomers of lansoprazole and its metabolite, 5-hydroxylansoprazole, in relation to CYP2C19 genotypes. Eur J Clin Pharmacol. 2004 Nov;60(9):623-8.

(R)-Lansoprazole 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.71mL

0.54mL

0.27mL

13.54mL

2.71mL

1.35mL

27.07mL

5.41mL

2.71mL

(R)-Lansoprazole 技术信息

CAS号138530-94-6
分子式C16H14F3N3O2S
分子量 369.361
别名 右兰索拉唑 ;Dexlansoprazole;T-168390;TAK-390;(+)-Lansoprazole
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C
溶解度

DMSO: 105 mg/mL(284.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: (R)-Lansoprazole | 138530-94-6 | Dexlansoprazole | Proton Pump | Proton Pump Inhibitor | Membrane Transporter/Ion Channel | Proton Pump | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | (R)-Lansoprazole 纯度/质量文件 | (R)-Lansoprazole 亚型比较 | (R)-Lansoprazole 生物活性 | (R)-Lansoprazole 临床数据 | (R)-Lansoprazole 参考文献 | (R)-Lansoprazole 实验方案 | (R)-Lansoprazole 技术信息

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