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Phenytoin sodium

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Chemical Structure| 630-93-3 同义名 : 5,5-Diphenylhydantoin sodium salt
CAS号 : 630-93-3
货号 : A228712
分子式 : C15H11N2NaO2
纯度 : 98%
分子量 : 274.25
MDL号 : MFCD00069674
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(182.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

PO 0.5% CMC-Na 65 mg/mL suspension

生物活性
靶点

  • Sodium Channel
描述 Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent blocker of Voltage-gated Na+ channels (VGSCs), possessing similar antiepileptic and anti-tumor properties in mice[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.65mL

0.73mL

0.36mL

18.23mL

3.65mL

1.82mL

36.46mL

7.29mL

3.65mL
参考文献

[1]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 27;14(1):13.

[2]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5(7): p. 553-64.

[3]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.