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/ PDGFR / Sennoside B

番泻苷 B /Sennoside B {[allProObj[0].p_purity_real_show]}

货号：A535597

Sennoside B inhibits PDGF-stimulated cell proliferation, it's a kind of irritant laxative isolated from rhei rhizome and leaves of Cassia angustifolia..

Sennoside B 化学结构 CAS号：128-57-4
Sennoside B 化学结构
CAS号：128-57-4
Sennoside B 3D分子结构
CAS号：128-57-4
Sennoside B 化学结构 CAS号：128-57-4
Sennoside B 3D分子结构 CAS号：128-57-4
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Sennoside B 纯度/质量文件 产品仅供科研

货号：A535597 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 PDGFR ↓ PDGFRα ↓ PDGFRβ ↓ 其他靶点 纯度
Tyrphostin A9 +

PDGFR, IC50: 0.5 μM

 		EGFR 98%
Tyrphostin AG1296 99%+
Motesanib Diphosphate ++

PDGFR, IC50: 84 nM

 		98%
Pazopanib ++

PDGFR, IC50: 84 nM

 		99%
Imatinib +

PDGFR, IC50: 100 nM

 		c-Kit 98%
Imatinib Mesylate +

PDGFR, IC50: 100 nM

 		c-Kit 99%
Sennoside B ✔ 99%+
PP121 ++++

PDGFR, IC50: 2 nM

 		VEGFR,mTOR 99%+
Crenolanib ++++

PDGFRα, Kd: 2.1 nM

 		++++

PDGFRβ, Kd: 3.2 nM

 		99%+
Masitinib +

PDGFRα, IC50: 540 nM

 		+

PDGFRβ, IC50: 800 nM

 		99%+
Ki8751 ++

PDGFRα, IC50: 67 nM

 		c-Kit 98+%
Tivozanib ++

PDGFRα, IC50: 40 nM

 		++

PDGFRβ, IC50: 49 nM

 		99%+
Ponatinib ++++

PDGFRα, IC50: 1.1 nM

 		98%
Amuvatinib ++

PDGFRα (V561D), IC50: 40 nM

 		99%+
Axitinib +++

PDGFRα, IC50: 5.0 nM

 		++++

PDGFRβ, IC50: 1.6 nM

 		98%
CP-673451 +++

PDGFRα, IC50: 10 nM

 		++++

PDGFRβ, IC50: 1 nM

 		99%+
Telatinib +++

PDGFRα, IC50: 15 nM

 		c-Kit 99%+
Nintedanib ++

PDGFRα, IC50: 59 nM

 		++

PDGFRβ, IC50: 65 nM

 		99+%
Avapritinib ++++

PDGFRα (D842V), IC50: 0.5 nM

 		99%+
MK-2461 +++

PDGFRβ, IC50: 22 nM

 		98%+
Lactate +++

PDGFRβ, IC50: 27 nM

 		FLT3,c-Kit 85%
Linifanib ++

PDGFRβ, IC50: 66 nM

 		99%+
AZD2932 +++

PDGFRβ, IC50: 4 nM

 		c-Kit 98%
Dovitinib +++

PDGFRβ, IC50: 27 nM

 		FLT3,c-Kit 99%+
Sorafenib ++

mPDGFRβ, IC50: 57 nM

PDGFRβ, IC50: 57 nM

 		99%
Sunitinib ++++

PDGFRβ , IC50: 2 nM

 		FLT3 98%
Orantinib +++

PDGFRβ, Ki: 8 nM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Sennoside B 生物活性

靶点

  • PDGFR
描述 Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF(platelet-derived growth factor)-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway[3]. The 50% inhibitory concentrations of the four sennosides (A, B, E and F) were 17, 9, 24 and 13 microM, respectively, and the type of inhibition by seenosides A and B with respect to allylamine as the substrate was non-competitive[4]. Intracaecal administration of rhein anthrone, the intraluminally active metabolite of sennosides A and B, to mice quickly induced severe diarrhoea[5]. From acute studies, sennosides could be classified as only slightly toxic in rats and mice after a single oral dose. The LD50 values were about 5,000 mg/kg in both species. In subacute studies with rats (max. 20 mg/kg) and dogs (max. 500 mg/kg), sennosides caused no specific local or systemic toxicity[6].

Sennoside B 参考文献

[1]Chen YC, Chang CN, et al. Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. Life Sci. 2009 Jun 19;84(25-26):915-22.

[2]Mengs U. Toxic effects of sennosides in laboratory animals and in vitro. Pharmacology. 1988;36 Suppl 1:180-7.

[3]Chen YC, Chang CN, Hsu HC, Chiou SJ, Lee LT, Hseu TH. Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. Life Sci. 2009 Jun 19;84(25-26):915-22

[4]Hiraoka A, Koike S, Sakaguchi S, Masuda Y, Terai F, Miura I, Kawasaki T, Kawai H, Sakakibara M. The sennoside constituents of rhei rhizoma and sennae folium as inhibitors of serum monoamine oxidase. Chem Pharm Bull (Tokyo). 1989 Oct;37(10):2744-6

[5]Yagi T, Miyawaki Y, Nishikawa T, Yamauchi K, Kuwano S. Involvement of prostaglandin E-like material in the purgative action of rhein anthrone, the intraluminal active metabolite of sennosides A and B in mice. J Pharm Pharmacol. 1988 Jan;40(1):27-30

[6]Mengs U. Toxic effects of sennosides in laboratory animals and in vitro. Pharmacology. 1988;36 Suppl 1:180-7

Sennoside B 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.16mL

0.23mL

0.12mL

5.80mL

1.16mL

0.58mL

11.59mL

2.32mL

1.16mL

Sennoside B 技术信息

CAS号128-57-4
分子式C42H38O20
分子量 862.739
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

DMSO: 105 mg/mL(121.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Sennoside B | PDGFR | AmBeed-信号通路专用抑制剂 | Sennoside B 纯度/质量文件 | Sennoside B 亚型比较 | Sennoside B 生物活性 | Sennoside B 参考文献 | Sennoside B 实验方案 | Sennoside B 技术信息

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