PD 151746
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货号：A477369
PD151746 is a calpain inhibitor, shows a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM).
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PD 151746 化学结构
PD 151746 3D分子结构
规格
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会员价
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PD 151746 纯度/质量文件 产品仅供科研
货号：A477369
标准纯度：
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产品说明书
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PD 151746 质控信息
Cysteine Protease 亚型比较
蛋白酶体 亚型比较
Z-FA-FMK
✔
99%+
Leupeptin hemisulfate
✔
97%
PMSF
✔
95%
PD 151746
+
m-calpain, IC50: 5.33 μM
μ-Calpain, IC50: 260 nM
98%
Odanacatib
++++
Cathepsin K (rabbit), IC50: 1 nM
Cathepsin K (human), IC50: 0.2 nM
99%+
E-64
+++
Cysteine protease, IC50: 9 nM
99%+
E 64c
✔
95%
E-64d
✔
99%+
MG-101
✔
98%+
Calpeptin
++
Calpain II (porcine kidney), ID50: 40 nM
Calpain I (porcine erythrocytes), ID50: 52 nM
98%+
Cathepsin inhibitor 1
+++
Cathepsin L2, pIC50: 5.5
Cathepsin L, pIC50: 7.9
98%
展开
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Ixazomib
++++
20S proteasome, IC50: 3.4 nM
20S proteasome, Ki: 0.93 nM
99%+
Delanzomib
+++
Chymotrypsin-like proteasome, IC50: 3.8 nM
98%
Celastrol
+
20S proteasome, IC50: 2.5 μM
98%
MLN9708
+++
20S proteasome, IC50: 3.4 nM
20S proteasome, Ki: 0.93 nM
99%
Bortezomib
++++
20S proteasome, Ki: 0.6 nM
98%
Oprozomib
++
20S proteasome LMP7, IC50: 82 nM
20S proteasome β5, IC50: 36 nM
99%+
Epoxomicin
✔
99%
PI-1840
++
Chymotrypsin-like proteasome, IC50: 27 nM
98%
VR23
+++
Trypsin-like proteasomes, IC50: 1 nM
Chymotrypsin-like proteasomes, IC50: 3 μM
98%
Carfilzomib
++
98%
(R)-MG-132
+
98%
展开
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
PD 151746 生物活性
靶点
Cysteine Protease
m-calpain, IC50:5.33 μM
μ-Calpain, IC50:260 nM
描述
PD151746 is a calpain inhibitor, shows a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM).
PD 151746 参考文献
PD 151746 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
4.21mL
0.84mL
0.42mL
21.07mL
4.21mL
2.11mL
42.15mL
8.43mL
4.21mL
PD 151746 技术信息
搜索
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