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Leupeptin hemisulfate
亮抑酶肽半硫酸盐 /Leupeptin hemisulfate
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货号：A663950
同义名：
亮肽素
/ Acetyl-L-leucyl-L-leucyl-L-argininal;Leupeptin (hemisulfate)
Leupeptin Hemisulfate is a reversible serine/cysteine protease inhibitor, inhibits cathepsins B, H, L, and S, calpain, and trypsin.
Leupeptin hemisulfate 化学结构
Leupeptin hemisulfate 3D分子结构
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Leupeptin hemisulfate 质控信息
Z-FA-FMK
✔
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Leupeptin hemisulfate
✔
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PMSF
✔
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PD 151746
+
μ-Calpain, IC50: 260 nM
m-calpain, IC50: 5.33 μM
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Odanacatib
++++
Cathepsin K (human), IC50: 0.2 nM
Cathepsin K (rabbit), IC50: 1 nM
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E-64
+++
Cysteine protease, IC50: 9 nM
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E 64c
✔
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E-64d
✔
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MG-101
✔
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Calpeptin
++
Calpain II (porcine kidney), ID50: 40 nM
Calpain I (porcine erythrocytes), ID50: 52 nM
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Cathepsin inhibitor 1
+++
Cathepsin L, pIC50: 7.9
Cathepsin L2, pIC50: 5.5
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Leupeptin hemisulfate 生物活性
靶点
描述
Leupeptin is a reversible and competitive serine/cysteine protease inhibitor which can inhibit proteolysis plasmin, trypsin and papain but not chymotrypsin. Oral administration of leupeptins exhibited an anti-inflammatory effect on edema. It inhibited thrombokinase reaction and coagulation of blood of human and rabbit, but not in rats and dogs[1] [2] [3]
作用机制
Leupeptin is competitive with substrates. The free aldehyde group plays a role in the activities.[1]
Leupeptin hemisulfate 动物研究
Dose
Mice: 9 mg/kg - 40 mg/kg[4]
Administration
i.p.
Leupeptin hemisulfate 参考文献
Leupeptin hemisulfate 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.05mL
0.21mL
0.11mL
5.26mL
1.05mL
0.53mL
10.51mL
2.10mL
1.05mL
Leupeptin hemisulfate 技术信息
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