There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
E 64 is a potent, irreversible, selective and water-soluble cysteine protease inhibitor with IC50 values of 1.4, 2.5 and 4.1 nM for cathepsin K, L and S, respectively, as well as exhibited inhibitory effect on papain, calpain, cathepsin B and cathepsin H, but not serine proteases (except trypsin)[1][2][3]. E 64 had no effect on the serine proteinases at a concentration of 0.5 mM, but could inhibit the serine proteinases trypsin[3]. Treatment with E 64 combined with pepstatin A could increase LC3-II accumulation due to the endogenous FoxO1 required autophagy induced by stress stimuli (oxidative stress or serum starvation)[4]. Through inhibition of cathepsins (lysosomal proteases), E 64 is used as lysosomal protease inhibitor[4][5]. E 64 is a main component of commercial used proteasome cocktail.
作用机制
The epoxysuccinyl group of E-64 irreversibly binds with an active thiol group of cysteine proteases to form a thioether linkage.[6]
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HazMat Fee +
