E-64c is a derivative of a naturally occurring epoxide that inhibits cysteine proteases, particularly effective against papain. This inhibition is characterized by the hydrogen bonding and hydrophobic interactions between the ligands and the conserved residues within the catalytic binding site[1]. E-64c has been identified as a primary structure for the creation of irreversible inhibitors targeting cathepsin C[2].
E 64c 动物研究
Animal study
The half-life (t-1/2) of E-64c in plasma is 0.48 hours. At this dosage, E-64c does not exhibit hemodynamic effects. Statistical analysis using two-way ANOVA reveals that both reperfusion and E-64c independently have significant effects on infarct size. The reduction in creatine phosphokinase (CPK) is marginally lower in the E-64c treated groups compared to the vehicle-injected groups. The limited efficacy of E-64c might be due to its early administration and the relatively short half-life. Given the established effectiveness of NCO-700, the results suggest that E-64c may have a modest yet positive impact on reducing infarct size and CPK levels[3].
搜索
