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ONC206

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Chemical Structure| 1638178-87-6 同义名 : -
CAS号 : 1638178-87-6
货号 : A1155605
分子式 : C23H22F2N4O
纯度 : 97%
分子量 : 408.444
MDL号 : MFCD32671364
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(122.42 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • D2 receptor
描述 ONC206 is a derivative of the TRAIL inducer ONC201[1]. ONC206 selectively antagonizes D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 exhibits wide-ranging antitumor efficacy[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.45mL

0.49mL

0.24mL

12.24mL

2.45mL

1.22mL

24.48mL

4.90mL

2.45mL
参考文献

[1]Wagner J, et al. Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212. Cell Cycle. 2017 Oct 2;16(19):1790-1799.

[2]Varun Vijay Prabhu, et al. Potent anti-cancer activity of the imipridone ONC206: A selective dopamine D2-like receptor antagonist. AACR Annual Meeting 2017, April 1-5, 2017; Washington, DC.