There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Niraparib tosylate hydrate is a potent oral bioactive PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively.Niraparib tosylate hydrate inhibits DNA damage repair, activates apoptosis, and displays antitumour activity[1][2][3].Niraparib tosylate hydrate inhibits PARP activity with EC50 value of 4 nM and EC90 value of 45 nM in whole-cell assay. Niraparib tosylate hydrate inhibits the proliferation of mutant BRCA-1 and BRCA-2 cancer cells with CC50 values in the range of 10-100 nM. Niraparib tosylate hydrate inhibited PARP 1 and PARP 2 very well, with IC50s of 3.8 and 2.1 nM in whole-cell assays, respectively[1].Niraparib tosylate hydrate inhibited PARP within 15 minutes of treatment, exhibiting approximately 85% inhibition in A549 cells within 1 hour and 55% inhibition in H1299 cells within 1 hour[2].
Niraparib tosylate hydrate 动物研究
Animal study
Niraparib tosylate hydrate has an acceptable pharmacokinetic profile in rats, with a plasma clearance of 28 (mL/min)/kg, a very large volume of distribution (Vdss=6.9 L/kg), a long terminal half-life (t1/2=3.4 h), and a high bioavailability (F=65%)[1].Niraparib tosylate hydrate potentiated the radiation response in p53 mutant Calu-6 tumours in both cases, with a single daily dose of 50 mg/kg being more effective than two daily doses of 25 mg/kg[3].
搜索
HazMat Fee +
