Magnolol | NSC 293099 | Plant Standard | RAR/RXR | NF-κB

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厚朴酚 /Magnolol {[allProObj[0].p_purity_real_show]}

货号：A326464 同义名： NSC 293099

Magnolol is a multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis, with antifungal, antibacterial and antioxidant effects, as well as anti-inflammatory activity by interferring with NF-κB signaling and inhibiting IL-6-induced STAT3 activation.

Magnolol 化学结构
CAS号：528-43-8

Magnolol 3D分子结构
CAS号：528-43-8

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Magnolol 纯度/质量文件产品仅供科研

货号：A326464 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

NF-κB 亚型比较

产品名称	NF-κB ↓ ↑	其他靶点	纯度
PDTC ammonium	✔		98%
QNZ	++++ NF-κB, IC50: 11 nM		99%+
Sodium 4-Aminosalicylate Dihydrate	✔		98%
Sodium Salicylate	✔		95%
Parthenolide	✔	p53	97% HPLC
JSH-23	+ NF-κB, IC50: 7.1 μM		98%
Phenethyl caffeate	✔		98%
Andrographolide	✔		98+%
Curcumin	✔	Nrf2,HDAC	98%
SC75741	+++ NF-κB, EC50: 200 nM		99%+
CBL0137 HCl	++ NF-κB, EC50: 0.47 μM	p53	99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Magnolol 生物活性

描述

Magnolol is a lignan with anti-inflammatory activity identified in Magnolia officinalis. Magnolol(5, 10 and 15 mg/kg) significantly attenuated disease activity index, inhibited colonic shortening, reduced colonic lesions and suppressed myeloperoxidase (MPO) activity^[3].Moreover, magnolol could effectively improve the carcass and meat quality of Linwu ducks by regulating the antioxidant status and would be a potential candidate to replace antibiotic^[4].

Magnolol 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00966953	-		Completed	-	-
NCT02310308	Dental Caries	Not Applicable	Unknown	November 2015	Italy ... 展开 >> Department of Surgery, Microsurgery and Medicine Sciences University of Sassari Sassari, Sardinia, Italy, I-07100 WHO CC University of Milan Milan, Italy, I-20121 收起 <<
NCT00966953	Gingival Diseases	Phase 3	Completed	-	United States, New York ... 展开 >> Eastman Dental Center - University of Rochester Rochester, New York, United States, 14642-8315 收起 <<

Magnolol 参考文献

[1]Ai J, Wang X, Nielsen M. Honokiol and magnolol selectively interact with GABAA receptor subtypes in vitro. Pharmacology. 2001 Jul;63(1):34-41.

[2]Bang KH, Kim YK, et al. Antifungal activity of magnolol and honokiol. Arch Pharm Res. 2000 Feb;23(1):46-9.

[3]Zhao L, Xiao HT, Mu HX, Huang T, Lin ZS, Zhong LLD, Zeng GZ, Fan BM, Lin CY, Bian ZX. Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules. 2017 Jul 20;22(7):1218. doi: 10.3390/molecules22071218. PMID: 28726741; PMCID: PMC6152296.

[4]Lin Q, Peng S, Li Y, Jiang G, Liao Z, Fan Z, He X, Dai Q. Magnolol additive improves carcass and meat quality of Linwu ducks by modulating antioxidative status. Anim Sci J. 2020 Jan-Dec;91(1):e13301. doi: 10.1111/asj.13301. Epub 2019 Nov 15. PMID: 31729108.

Magnolol 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.75mL

0.75mL

0.38mL

18.77mL

3.75mL

1.88mL

37.55mL

7.51mL

3.75mL

Magnolol 技术信息

CAS号	528-43-8
分子式	C₁₈H₁₈O₂
分子量	266.334

别名	NSC 293099
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 105 mg/mL(394.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

IP 2% DMSO+2% Tween80+30% PEG300+water 6 mg/mL clear

PO 0.5% CMC-Na 42 mg/mL suspension

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00966953	-		Completed	-	-
NCT02310308	Dental Caries	Not Applicable	Unknown	November 2015	Italy ... 展开 >> Department of Surgery, Microsurgery and Medicine Sciences University of Sassari Sassari, Sardinia, Italy, I-07100 WHO CC University of Milan Milan, Italy, I-20121 收起 <<
NCT00966953	Gingival Diseases	Phase 3	Completed	-	United States, New York ... 展开 >> Eastman Dental Center - University of Rochester Rochester, New York, United States, 14642-8315 收起 <<

厚朴酚 /Magnolol {[allProObj[0].p_purity_real_show]}

Magnolol 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Magnolol 质控信息

Magnolol 生物活性

Magnolol 临床研究

Magnolol 参考文献

Magnolol 实验方案

Magnolol 技术信息

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厚朴酚 /Magnolol {[allProObj[0].p_purity_real_show]}

Magnolol 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Magnolol 质控信息

Magnolol 生物活性

Magnolol 临床研究

Magnolol 参考文献

Magnolol 实验方案

Magnolol 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Magnolol 纯度/质量文件产品仅供科研